| Full name: BLM RecQ like helicase | Alias Symbol: BS|RECQL3|RECQ2 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 641 | HGNC ID: HGNC:1058 | Ensembl Gene: ENSG00000197299 | OMIM ID: 604610 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
BLM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of BLM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BLM | 641 | 205733_at | 1.5549 | 0.0250 | |
| GSE20347 | BLM | 641 | 205733_at | 1.7155 | 0.0000 | |
| GSE23400 | BLM | 641 | 205733_at | 0.5243 | 0.0000 | |
| GSE26886 | BLM | 641 | 205733_at | 1.2582 | 0.0000 | |
| GSE29001 | BLM | 641 | 205733_at | 1.0561 | 0.0000 | |
| GSE38129 | BLM | 641 | 205733_at | 1.6983 | 0.0000 | |
| GSE45670 | BLM | 641 | 205733_at | 1.3200 | 0.0000 | |
| GSE53622 | BLM | 641 | 143108 | 1.8160 | 0.0000 | |
| GSE53624 | BLM | 641 | 143108 | 1.9034 | 0.0000 | |
| GSE63941 | BLM | 641 | 205733_at | 3.0703 | 0.0000 | |
| GSE77861 | BLM | 641 | 205733_at | 0.9709 | 0.0149 | |
| GSE97050 | BLM | 641 | A_23_P88630 | 0.5321 | 0.1368 | |
| SRP007169 | BLM | 641 | RNAseq | 2.0087 | 0.0000 | |
| SRP008496 | BLM | 641 | RNAseq | 1.6983 | 0.0001 | |
| SRP064894 | BLM | 641 | RNAseq | 1.4447 | 0.0000 | |
| SRP133303 | BLM | 641 | RNAseq | 1.5809 | 0.0000 | |
| SRP159526 | BLM | 641 | RNAseq | 1.9488 | 0.0000 | |
| SRP193095 | BLM | 641 | RNAseq | 1.1102 | 0.0000 | |
| SRP219564 | BLM | 641 | RNAseq | 2.0070 | 0.0002 | |
| TCGA | BLM | 641 | RNAseq | 1.1335 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by BLM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BLM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BLM | 641 | 8 | 2 | 20 | |
| GSE20123 | BLM | 641 | 8 | 2 | 20 | |
| GSE43470 | BLM | 641 | 5 | 5 | 33 | |
| GSE46452 | BLM | 641 | 3 | 7 | 49 | |
| GSE47630 | BLM | 641 | 8 | 11 | 21 | |
| GSE54993 | BLM | 641 | 4 | 6 | 60 | |
| GSE54994 | BLM | 641 | 7 | 7 | 39 | |
| GSE60625 | BLM | 641 | 4 | 0 | 7 | |
| GSE74703 | BLM | 641 | 4 | 4 | 28 | |
| GSE74704 | BLM | 641 | 4 | 2 | 14 | |
| TCGA | BLM | 641 | 18 | 12 | 66 |
Total number of gains: 73; Total number of losses: 58; Total Number of normals: 357.
Somatic mutations of BLM:
Generating mutation plots.
Highly correlated genes for BLM:
Showing top 20/2044 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BLM | FANCI | 0.851018 | 13 | 0 | 13 |
| BLM | KNSTRN | 0.843468 | 7 | 0 | 7 |
| BLM | UBE2T | 0.829577 | 9 | 0 | 8 |
| BLM | PRC1 | 0.828613 | 13 | 0 | 13 |
| BLM | UCK2 | 0.826089 | 3 | 0 | 3 |
| BLM | DKC1 | 0.823618 | 3 | 0 | 3 |
| BLM | TICRR | 0.817634 | 5 | 0 | 5 |
| BLM | CCNB2 | 0.810815 | 12 | 0 | 12 |
| BLM | GINS1 | 0.807793 | 12 | 0 | 12 |
| BLM | MTFR2 | 0.80528 | 7 | 0 | 7 |
| BLM | CENPF | 0.804628 | 13 | 0 | 12 |
| BLM | EXO1 | 0.80452 | 12 | 0 | 12 |
| BLM | TTK | 0.803573 | 13 | 0 | 12 |
| BLM | MMS22L | 0.802378 | 3 | 0 | 3 |
| BLM | NUSAP1 | 0.802051 | 13 | 0 | 12 |
| BLM | TPX2 | 0.801138 | 12 | 0 | 12 |
| BLM | CDC45 | 0.799378 | 12 | 0 | 12 |
| BLM | NUF2 | 0.798219 | 9 | 0 | 9 |
| BLM | CENPL | 0.795144 | 8 | 0 | 8 |
| BLM | NCAPG2 | 0.794986 | 11 | 0 | 11 |
For details and further investigation, click here
