| Full name: helicase, lymphoid specific | Alias Symbol: PASG|SMARCA6|LSH|Nbla10143 | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 3070 | HGNC ID: HGNC:4861 | Ensembl Gene: ENSG00000119969 | OMIM ID: 603946 |
| Drug and gene relationship at DGIdb | |||
Expression of HELLS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HELLS | 3070 | 227350_at | 1.4698 | 0.0400 | |
| GSE20347 | HELLS | 3070 | 220085_at | 0.7001 | 0.0123 | |
| GSE23400 | HELLS | 3070 | 220085_at | 0.6358 | 0.0000 | |
| GSE26886 | HELLS | 3070 | 223556_at | 1.1727 | 0.0008 | |
| GSE29001 | HELLS | 3070 | 220085_at | 0.8448 | 0.0821 | |
| GSE38129 | HELLS | 3070 | 220085_at | 1.1677 | 0.0007 | |
| GSE45670 | HELLS | 3070 | 227350_at | 0.8380 | 0.0010 | |
| GSE53622 | HELLS | 3070 | 51374 | 1.3403 | 0.0000 | |
| GSE53624 | HELLS | 3070 | 51374 | 1.6436 | 0.0000 | |
| GSE63941 | HELLS | 3070 | 227350_at | 2.3011 | 0.0000 | |
| GSE77861 | HELLS | 3070 | 220085_at | 1.0176 | 0.0783 | |
| GSE97050 | HELLS | 3070 | A_33_P3258117 | 1.4632 | 0.1363 | |
| SRP007169 | HELLS | 3070 | RNAseq | 1.9285 | 0.0011 | |
| SRP008496 | HELLS | 3070 | RNAseq | 1.5196 | 0.0002 | |
| SRP064894 | HELLS | 3070 | RNAseq | 0.9899 | 0.0013 | |
| SRP133303 | HELLS | 3070 | RNAseq | 1.2157 | 0.0000 | |
| SRP159526 | HELLS | 3070 | RNAseq | 1.1271 | 0.0028 | |
| SRP193095 | HELLS | 3070 | RNAseq | 0.8530 | 0.0000 | |
| SRP219564 | HELLS | 3070 | RNAseq | 1.5533 | 0.0250 | |
| TCGA | HELLS | 3070 | RNAseq | 0.8524 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by HELLS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HELLS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HELLS | 3070 | 1 | 8 | 21 | |
| GSE20123 | HELLS | 3070 | 1 | 7 | 22 | |
| GSE43470 | HELLS | 3070 | 0 | 7 | 36 | |
| GSE46452 | HELLS | 3070 | 0 | 11 | 48 | |
| GSE47630 | HELLS | 3070 | 2 | 14 | 24 | |
| GSE54993 | HELLS | 3070 | 7 | 0 | 63 | |
| GSE54994 | HELLS | 3070 | 2 | 10 | 41 | |
| GSE60625 | HELLS | 3070 | 0 | 0 | 11 | |
| GSE74703 | HELLS | 3070 | 0 | 5 | 31 | |
| GSE74704 | HELLS | 3070 | 0 | 4 | 16 | |
| TCGA | HELLS | 3070 | 6 | 26 | 64 |
Total number of gains: 19; Total number of losses: 92; Total Number of normals: 377.
Somatic mutations of HELLS:
Generating mutation plots.
Highly correlated genes for HELLS:
Showing top 20/1401 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HELLS | TTK | 0.780233 | 12 | 0 | 12 |
| HELLS | NUF2 | 0.764633 | 9 | 0 | 8 |
| HELLS | DTL | 0.763267 | 13 | 0 | 12 |
| HELLS | CDK1 | 0.75934 | 12 | 0 | 12 |
| HELLS | UCK2 | 0.754361 | 3 | 0 | 3 |
| HELLS | UBE2T | 0.753284 | 9 | 0 | 8 |
| HELLS | MTFR2 | 0.752766 | 7 | 0 | 7 |
| HELLS | ASPM | 0.748765 | 13 | 0 | 12 |
| HELLS | CENPF | 0.744877 | 13 | 0 | 12 |
| HELLS | ZGRF1 | 0.743338 | 5 | 0 | 5 |
| HELLS | SLC19A1 | 0.742795 | 3 | 0 | 3 |
| HELLS | BUB1B | 0.739692 | 9 | 0 | 9 |
| HELLS | TRIP13 | 0.737521 | 12 | 0 | 12 |
| HELLS | CDCA2 | 0.737451 | 6 | 0 | 6 |
| HELLS | ZNF367 | 0.7335 | 8 | 0 | 8 |
| HELLS | NOTCH3 | 0.732748 | 3 | 0 | 3 |
| HELLS | PLK1 | 0.730354 | 9 | 0 | 9 |
| HELLS | CCNA2 | 0.730345 | 13 | 0 | 12 |
| HELLS | GINS1 | 0.729139 | 12 | 0 | 12 |
| HELLS | RCC2 | 0.728669 | 6 | 0 | 6 |
For details and further investigation, click here
