PPP2R1B

 

Full name: protein phosphatase 2 scaffold subunit Abeta Alias Symbol: PR65B|PP2A-Abeta
Type: protein-coding gene Cytoband: 11q23.1
Entrez ID: 5519 HGNC ID: HGNC:9303 Ensembl Gene: ENSG00000137713 OMIM ID: 603113
Drug and gene relationship at DGIdb
Screen Evidence:

 

PPP2R1B involved pathways:

KEGG pathway Description View
hsa04071Sphingolipid signaling pathway
hsa04114Oocyte meiosis
hsa04151PI3K-Akt signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04530Tight junction
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa05142Chagas disease (American trypanosomiasis)
hsa05160Hepatitis C

 

Expression of PPP2R1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PPP2R1B 5519 202883_s_at 0.4205 0.3568
GSE20347 PPP2R1B 5519 202883_s_at -0.4028 0.0139
GSE23400 PPP2R1B 5519 202883_s_at -0.1255 0.0982
GSE26886 PPP2R1B 5519 202883_s_at -0.7348 0.0004
GSE29001 PPP2R1B 5519 202883_s_at -0.1434 0.6176
GSE38129 PPP2R1B 5519 202883_s_at -0.1338 0.4535
GSE45670 PPP2R1B 5519 202883_s_at 0.2541 0.1345
GSE53622 PPP2R1B 5519 36125 -0.2801 0.0003
GSE53624 PPP2R1B 5519 36125 -0.5222 0.0000
GSE63941 PPP2R1B 5519 202883_s_at -0.0954 0.8204
GSE77861 PPP2R1B 5519 202883_s_at -0.0893 0.8626
GSE97050 PPP2R1B 5519 A_24_P107291 0.2827 0.3384
SRP007169 PPP2R1B 5519 RNAseq -0.8040 0.0420
SRP008496 PPP2R1B 5519 RNAseq -0.8883 0.0001
SRP064894 PPP2R1B 5519 RNAseq -0.6120 0.0006
SRP133303 PPP2R1B 5519 RNAseq -0.1864 0.2026
SRP159526 PPP2R1B 5519 RNAseq -0.3067 0.2950
SRP193095 PPP2R1B 5519 RNAseq -0.4596 0.0006
SRP219564 PPP2R1B 5519 RNAseq -0.0583 0.9020
TCGA PPP2R1B 5519 RNAseq -0.2629 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PPP2R1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PPP2R1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PPP2R1B 5519 0 12 18
GSE20123 PPP2R1B 5519 0 12 18
GSE43470 PPP2R1B 5519 2 6 35
GSE46452 PPP2R1B 5519 3 26 30
GSE47630 PPP2R1B 5519 2 19 19
GSE54993 PPP2R1B 5519 10 0 60
GSE54994 PPP2R1B 5519 5 19 29
GSE60625 PPP2R1B 5519 0 3 8
GSE74703 PPP2R1B 5519 1 4 31
GSE74704 PPP2R1B 5519 0 8 12
TCGA PPP2R1B 5519 6 48 42

Total number of gains: 29; Total number of losses: 157; Total Number of normals: 302.  

 

Somatic mutations of PPP2R1B:

 

Generating mutation plots.

 

Highly correlated genes for PPP2R1B:

 

Showing top 20/437 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PPP2R1BPOLG0.828357303
PPP2R1BTMEM170A0.792572303
PPP2R1BKDM1B0.7874303
PPP2R1BALG80.772878303
PPP2R1BDNAJB60.769799303
PPP2R1BSLBP0.763966303
PPP2R1BGEN10.763955303
PPP2R1BYWHAE0.754963303
PPP2R1BHYLS10.753838303
PPP2R1BTRUB10.742696303
PPP2R1BZNF6070.742378303
PPP2R1BSLC30A60.741626303
PPP2R1BHNRNPA30.73836303
PPP2R1BNPRL20.733879303
PPP2R1BBRI3BP0.727818303
PPP2R1BPDIK1L0.727785303
PPP2R1BCRLS10.72468303
PPP2R1BUSP160.722667303
PPP2R1BLYSMD30.716557303
PPP2R1BWDR30.713335403

For details and further investigation, click here