| Full name: methyl-CpG binding domain protein 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.2 | ||
| Entrez ID: 8932 | HGNC ID: HGNC:6917 | Ensembl Gene: ENSG00000134046 | OMIM ID: 603547 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MBD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBD2 | 8932 | 202484_s_at | -0.2259 | 0.6976 | |
| GSE20347 | MBD2 | 8932 | 202484_s_at | -0.7292 | 0.0001 | |
| GSE23400 | MBD2 | 8932 | 202484_s_at | -0.3375 | 0.0060 | |
| GSE26886 | MBD2 | 8932 | 202484_s_at | -0.4177 | 0.0100 | |
| GSE29001 | MBD2 | 8932 | 202484_s_at | -0.5961 | 0.0496 | |
| GSE38129 | MBD2 | 8932 | 202484_s_at | -0.3762 | 0.0884 | |
| GSE45670 | MBD2 | 8932 | 202484_s_at | -0.1805 | 0.1860 | |
| GSE53622 | MBD2 | 8932 | 57602 | -0.5458 | 0.0000 | |
| GSE53624 | MBD2 | 8932 | 57602 | -0.5246 | 0.0000 | |
| GSE63941 | MBD2 | 8932 | 202484_s_at | -0.5528 | 0.2653 | |
| GSE77861 | MBD2 | 8932 | 202484_s_at | -0.4206 | 0.2888 | |
| GSE97050 | MBD2 | 8932 | A_23_P15864 | -0.0199 | 0.9605 | |
| SRP007169 | MBD2 | 8932 | RNAseq | -1.7505 | 0.0000 | |
| SRP008496 | MBD2 | 8932 | RNAseq | -1.4610 | 0.0000 | |
| SRP064894 | MBD2 | 8932 | RNAseq | -0.7523 | 0.0000 | |
| SRP133303 | MBD2 | 8932 | RNAseq | -0.5019 | 0.0087 | |
| SRP159526 | MBD2 | 8932 | RNAseq | -0.6125 | 0.1513 | |
| SRP193095 | MBD2 | 8932 | RNAseq | -0.6234 | 0.0000 | |
| SRP219564 | MBD2 | 8932 | RNAseq | -1.0687 | 0.0252 | |
| TCGA | MBD2 | 8932 | RNAseq | 0.1767 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MBD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBD2 | 8932 | 1 | 9 | 20 | |
| GSE20123 | MBD2 | 8932 | 1 | 9 | 20 | |
| GSE43470 | MBD2 | 8932 | 0 | 5 | 38 | |
| GSE46452 | MBD2 | 8932 | 1 | 26 | 32 | |
| GSE47630 | MBD2 | 8932 | 5 | 20 | 15 | |
| GSE54993 | MBD2 | 8932 | 10 | 0 | 60 | |
| GSE54994 | MBD2 | 8932 | 2 | 16 | 35 | |
| GSE60625 | MBD2 | 8932 | 0 | 4 | 7 | |
| GSE74703 | MBD2 | 8932 | 0 | 5 | 31 | |
| GSE74704 | MBD2 | 8932 | 1 | 6 | 13 | |
| TCGA | MBD2 | 8932 | 10 | 43 | 43 |
Total number of gains: 31; Total number of losses: 143; Total Number of normals: 314.
Somatic mutations of MBD2:
Generating mutation plots.
Highly correlated genes for MBD2:
Showing top 20/1255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBD2 | ELOVL1 | 0.759 | 3 | 0 | 3 |
| MBD2 | NPRL2 | 0.742002 | 3 | 0 | 3 |
| MBD2 | PTPRA | 0.728372 | 4 | 0 | 4 |
| MBD2 | VPS4B | 0.727067 | 13 | 0 | 12 |
| MBD2 | MPZL2 | 0.724975 | 11 | 0 | 11 |
| MBD2 | CKMT1A | 0.721897 | 3 | 0 | 3 |
| MBD2 | RAB27B | 0.713828 | 10 | 0 | 10 |
| MBD2 | SPA17 | 0.709081 | 3 | 0 | 3 |
| MBD2 | ABI1 | 0.708321 | 9 | 0 | 8 |
| MBD2 | BTBD7 | 0.703988 | 5 | 0 | 5 |
| MBD2 | FBXL16 | 0.701664 | 5 | 0 | 5 |
| MBD2 | DENND1B | 0.700322 | 7 | 0 | 6 |
| MBD2 | VPS53 | 0.700104 | 4 | 0 | 3 |
| MBD2 | TXNL1 | 0.697988 | 13 | 0 | 11 |
| MBD2 | KCTD1 | 0.696959 | 4 | 0 | 4 |
| MBD2 | SERPINB8 | 0.689893 | 12 | 0 | 9 |
| MBD2 | CLTA | 0.687942 | 5 | 0 | 5 |
| MBD2 | RWDD2B | 0.685853 | 3 | 0 | 3 |
| MBD2 | TWF1 | 0.68414 | 10 | 0 | 9 |
| MBD2 | ESYT2 | 0.677624 | 3 | 0 | 3 |
For details and further investigation, click here
