| Full name: NPR3 like, GATOR1 complex subunit | Alias Symbol: CGTHBA|RMD11|NPR3|MARE|HS-40 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 8131 | HGNC ID: HGNC:14124 | Ensembl Gene: ENSG00000103148 | OMIM ID: 600928 |
| Drug and gene relationship at DGIdb | |||
NPRL3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of NPRL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPRL3 | 8131 | 210672_s_at | 0.4201 | 0.3827 | |
| GSE20347 | NPRL3 | 8131 | 214273_x_at | 0.3839 | 0.0025 | |
| GSE23400 | NPRL3 | 8131 | 214273_x_at | 0.1128 | 0.0108 | |
| GSE26886 | NPRL3 | 8131 | 214273_x_at | 0.7210 | 0.0000 | |
| GSE29001 | NPRL3 | 8131 | 210672_s_at | 0.2006 | 0.3227 | |
| GSE38129 | NPRL3 | 8131 | 214273_x_at | 0.3183 | 0.0006 | |
| GSE45670 | NPRL3 | 8131 | 214273_x_at | 0.0817 | 0.5862 | |
| GSE53622 | NPRL3 | 8131 | 75160 | 0.1922 | 0.0063 | |
| GSE53624 | NPRL3 | 8131 | 75160 | 0.4169 | 0.0000 | |
| GSE63941 | NPRL3 | 8131 | 214273_x_at | 0.6571 | 0.0573 | |
| GSE77861 | NPRL3 | 8131 | 203289_s_at | 0.0864 | 0.5895 | |
| GSE97050 | NPRL3 | 8131 | A_23_P100326 | 0.2274 | 0.6013 | |
| SRP007169 | NPRL3 | 8131 | RNAseq | 1.1106 | 0.0549 | |
| SRP064894 | NPRL3 | 8131 | RNAseq | 0.6193 | 0.0035 | |
| SRP133303 | NPRL3 | 8131 | RNAseq | 0.4177 | 0.1261 | |
| SRP159526 | NPRL3 | 8131 | RNAseq | 0.4680 | 0.1353 | |
| SRP193095 | NPRL3 | 8131 | RNAseq | 0.5564 | 0.0000 | |
| SRP219564 | NPRL3 | 8131 | RNAseq | 0.6944 | 0.0673 | |
| TCGA | NPRL3 | 8131 | RNAseq | 0.1107 | 0.0261 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NPRL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPRL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPRL3 | 8131 | 5 | 5 | 20 | |
| GSE20123 | NPRL3 | 8131 | 5 | 4 | 21 | |
| GSE43470 | NPRL3 | 8131 | 3 | 7 | 33 | |
| GSE46452 | NPRL3 | 8131 | 38 | 1 | 20 | |
| GSE47630 | NPRL3 | 8131 | 13 | 6 | 21 | |
| GSE54993 | NPRL3 | 8131 | 3 | 5 | 62 | |
| GSE54994 | NPRL3 | 8131 | 4 | 10 | 39 | |
| GSE60625 | NPRL3 | 8131 | 4 | 0 | 7 | |
| GSE74703 | NPRL3 | 8131 | 3 | 5 | 28 | |
| GSE74704 | NPRL3 | 8131 | 3 | 2 | 15 | |
| TCGA | NPRL3 | 8131 | 20 | 15 | 61 |
Total number of gains: 101; Total number of losses: 60; Total Number of normals: 327.
Somatic mutations of NPRL3:
Generating mutation plots.
Highly correlated genes for NPRL3:
Showing top 20/907 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPRL3 | ALG1 | 0.822453 | 3 | 0 | 3 |
| NPRL3 | DTD1 | 0.810105 | 3 | 0 | 3 |
| NPRL3 | DNTTIP1 | 0.801716 | 4 | 0 | 4 |
| NPRL3 | HIBADH | 0.789772 | 3 | 0 | 3 |
| NPRL3 | SLC30A7 | 0.782669 | 3 | 0 | 3 |
| NPRL3 | ZNF594 | 0.770112 | 3 | 0 | 3 |
| NPRL3 | MRPL38 | 0.769883 | 4 | 0 | 4 |
| NPRL3 | AAGAB | 0.763778 | 3 | 0 | 3 |
| NPRL3 | DNAJC19 | 0.761567 | 3 | 0 | 3 |
| NPRL3 | ABCF2 | 0.760867 | 4 | 0 | 4 |
| NPRL3 | EARS2 | 0.757053 | 4 | 0 | 4 |
| NPRL3 | SPNS1 | 0.746965 | 4 | 0 | 3 |
| NPRL3 | FAM111B | 0.741753 | 3 | 0 | 3 |
| NPRL3 | TRIM47 | 0.738706 | 3 | 0 | 3 |
| NPRL3 | USP28 | 0.736251 | 3 | 0 | 3 |
| NPRL3 | RPS14 | 0.735606 | 3 | 0 | 3 |
| NPRL3 | PDPR | 0.734951 | 4 | 0 | 4 |
| NPRL3 | LTBR | 0.734749 | 4 | 0 | 3 |
| NPRL3 | TNFSF13 | 0.733923 | 4 | 0 | 4 |
| NPRL3 | ZNF200 | 0.731647 | 4 | 0 | 3 |
For details and further investigation, click here
