| Full name: NRDE-2, necessary for RNA interference, domain containing | Alias Symbol: FLJ14051 | ||
| Type: protein-coding gene | Cytoband: 14q32.11 | ||
| Entrez ID: 55051 | HGNC ID: HGNC:20186 | Ensembl Gene: ENSG00000119720 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of NRDE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NRDE2 | 55051 | 227575_s_at | 0.2651 | 0.5130 | |
| GSE20347 | NRDE2 | 55051 | 221231_s_at | -0.2049 | 0.0015 | |
| GSE23400 | NRDE2 | 55051 | 221231_s_at | -0.1577 | 0.0000 | |
| GSE26886 | NRDE2 | 55051 | 227575_s_at | 0.7344 | 0.0157 | |
| GSE29001 | NRDE2 | 55051 | 221231_s_at | 0.0053 | 0.9685 | |
| GSE38129 | NRDE2 | 55051 | 221231_s_at | -0.1264 | 0.0616 | |
| GSE45670 | NRDE2 | 55051 | 227575_s_at | 0.3693 | 0.0353 | |
| GSE53622 | NRDE2 | 55051 | 40393 | 0.2970 | 0.0019 | |
| GSE53624 | NRDE2 | 55051 | 40393 | 0.3115 | 0.0001 | |
| GSE63941 | NRDE2 | 55051 | 227575_s_at | 0.1313 | 0.8000 | |
| GSE77861 | NRDE2 | 55051 | 235212_at | -0.1775 | 0.2429 | |
| SRP007169 | NRDE2 | 55051 | RNAseq | 1.3230 | 0.0097 | |
| SRP008496 | NRDE2 | 55051 | RNAseq | 1.0153 | 0.0028 | |
| SRP064894 | NRDE2 | 55051 | RNAseq | 0.6863 | 0.0000 | |
| SRP133303 | NRDE2 | 55051 | RNAseq | 0.1472 | 0.3020 | |
| SRP159526 | NRDE2 | 55051 | RNAseq | 0.2854 | 0.2930 | |
| SRP193095 | NRDE2 | 55051 | RNAseq | 0.2705 | 0.0023 | |
| SRP219564 | NRDE2 | 55051 | RNAseq | 0.5107 | 0.0452 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NRDE2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of NRDE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NRDE2 | 55051 | 9 | 5 | 16 | |
| GSE20123 | NRDE2 | 55051 | 9 | 5 | 16 | |
| GSE43470 | NRDE2 | 55051 | 7 | 3 | 33 | |
| GSE46452 | NRDE2 | 55051 | 16 | 3 | 40 | |
| GSE47630 | NRDE2 | 55051 | 11 | 8 | 21 | |
| GSE54993 | NRDE2 | 55051 | 3 | 8 | 59 | |
| GSE54994 | NRDE2 | 55051 | 19 | 4 | 30 | |
| GSE60625 | NRDE2 | 55051 | 0 | 2 | 9 | |
| GSE74703 | NRDE2 | 55051 | 6 | 3 | 27 | |
| GSE74704 | NRDE2 | 55051 | 4 | 4 | 12 | |
| TCGA | NRDE2 | 55051 | 31 | 21 | 44 |
Total number of gains: 115; Total number of losses: 66; Total Number of normals: 307.
Somatic mutations of NRDE2:
Generating mutation plots.
Highly correlated genes for NRDE2:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NRDE2 | MRPL37 | 0.674557 | 3 | 0 | 3 |
| NRDE2 | BRMS1L | 0.655355 | 4 | 0 | 3 |
| NRDE2 | COX16 | 0.619821 | 4 | 0 | 3 |
| NRDE2 | ISCA2 | 0.615182 | 6 | 0 | 5 |
| NRDE2 | GPATCH4 | 0.607361 | 3 | 0 | 3 |
| NRDE2 | TTC8 | 0.607267 | 5 | 0 | 3 |
| NRDE2 | METTL6 | 0.605475 | 5 | 0 | 3 |
| NRDE2 | FCF1 | 0.604803 | 4 | 0 | 3 |
| NRDE2 | FANCM | 0.604508 | 4 | 0 | 4 |
| NRDE2 | MYO3B | 0.601008 | 3 | 0 | 3 |
| NRDE2 | PXN-AS1 | 0.600127 | 4 | 0 | 3 |
| NRDE2 | SLC39A9 | 0.599581 | 5 | 0 | 4 |
| NRDE2 | PAGE1 | 0.599309 | 5 | 0 | 4 |
| NRDE2 | CEP131 | 0.596354 | 4 | 0 | 4 |
| NRDE2 | LRRC69 | 0.595444 | 3 | 0 | 3 |
| NRDE2 | JKAMP | 0.594857 | 6 | 0 | 5 |
| NRDE2 | AREL1 | 0.591247 | 4 | 0 | 3 |
| NRDE2 | WDR25 | 0.584398 | 6 | 0 | 4 |
| NRDE2 | PRM2 | 0.583804 | 3 | 0 | 3 |
| NRDE2 | KLHDC2 | 0.582785 | 5 | 0 | 3 |
For details and further investigation, click here
