| Full name: kelch domain containing 2 | Alias Symbol: HCLP-1|LCP | ||
| Type: protein-coding gene | Cytoband: 14q21.3 | ||
| Entrez ID: 23588 | HGNC ID: HGNC:20231 | Ensembl Gene: ENSG00000165516 | OMIM ID: 611280 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHDC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHDC2 | 23588 | 217906_at | 0.1110 | 0.9165 | |
| GSE20347 | KLHDC2 | 23588 | 217906_at | -0.0637 | 0.7785 | |
| GSE23400 | KLHDC2 | 23588 | 217906_at | 0.1776 | 0.0492 | |
| GSE26886 | KLHDC2 | 23588 | 217906_at | 0.5412 | 0.0172 | |
| GSE29001 | KLHDC2 | 23588 | 217906_at | -0.0313 | 0.9460 | |
| GSE38129 | KLHDC2 | 23588 | 217906_at | -0.2426 | 0.1258 | |
| GSE45670 | KLHDC2 | 23588 | 217906_at | -0.6171 | 0.0000 | |
| GSE53622 | KLHDC2 | 23588 | 56533 | -0.3185 | 0.0006 | |
| GSE53624 | KLHDC2 | 23588 | 56533 | -0.4146 | 0.0000 | |
| GSE63941 | KLHDC2 | 23588 | 217906_at | -0.3689 | 0.5333 | |
| GSE77861 | KLHDC2 | 23588 | 217906_at | -0.2218 | 0.7301 | |
| GSE97050 | KLHDC2 | 23588 | A_24_P116242 | -0.2537 | 0.4581 | |
| SRP007169 | KLHDC2 | 23588 | RNAseq | -1.2407 | 0.0031 | |
| SRP008496 | KLHDC2 | 23588 | RNAseq | -0.7025 | 0.0129 | |
| SRP064894 | KLHDC2 | 23588 | RNAseq | -0.2775 | 0.0205 | |
| SRP133303 | KLHDC2 | 23588 | RNAseq | -0.0994 | 0.6104 | |
| SRP159526 | KLHDC2 | 23588 | RNAseq | -0.3835 | 0.0412 | |
| SRP193095 | KLHDC2 | 23588 | RNAseq | -0.4700 | 0.0002 | |
| SRP219564 | KLHDC2 | 23588 | RNAseq | -0.3200 | 0.2949 | |
| TCGA | KLHDC2 | 23588 | RNAseq | -0.2680 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KLHDC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHDC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHDC2 | 23588 | 8 | 2 | 20 | |
| GSE20123 | KLHDC2 | 23588 | 8 | 3 | 19 | |
| GSE43470 | KLHDC2 | 23588 | 7 | 1 | 35 | |
| GSE46452 | KLHDC2 | 23588 | 16 | 3 | 40 | |
| GSE47630 | KLHDC2 | 23588 | 11 | 10 | 19 | |
| GSE54993 | KLHDC2 | 23588 | 3 | 9 | 58 | |
| GSE54994 | KLHDC2 | 23588 | 19 | 4 | 30 | |
| GSE60625 | KLHDC2 | 23588 | 0 | 2 | 9 | |
| GSE74703 | KLHDC2 | 23588 | 6 | 1 | 29 | |
| GSE74704 | KLHDC2 | 23588 | 3 | 2 | 15 | |
| TCGA | KLHDC2 | 23588 | 34 | 13 | 49 |
Total number of gains: 115; Total number of losses: 50; Total Number of normals: 323.
Somatic mutations of KLHDC2:
Generating mutation plots.
Highly correlated genes for KLHDC2:
Showing top 20/548 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHDC2 | OSBPL9 | 0.831606 | 3 | 0 | 3 |
| KLHDC2 | FBXO33 | 0.803401 | 4 | 0 | 4 |
| KLHDC2 | RBM8A | 0.788834 | 3 | 0 | 3 |
| KLHDC2 | TCEA1 | 0.786715 | 3 | 0 | 3 |
| KLHDC2 | PTPN12 | 0.779214 | 3 | 0 | 3 |
| KLHDC2 | ACBD6 | 0.764949 | 3 | 0 | 3 |
| KLHDC2 | UBA2 | 0.758125 | 3 | 0 | 3 |
| KLHDC2 | COMMD8 | 0.750354 | 3 | 0 | 3 |
| KLHDC2 | NCOR1 | 0.749532 | 3 | 0 | 3 |
| KLHDC2 | LUC7L2 | 0.747869 | 3 | 0 | 3 |
| KLHDC2 | POLR3C | 0.737995 | 5 | 0 | 5 |
| KLHDC2 | PAPLN | 0.733887 | 3 | 0 | 3 |
| KLHDC2 | GLRX3 | 0.729027 | 3 | 0 | 3 |
| KLHDC2 | ATP6V1H | 0.727249 | 3 | 0 | 3 |
| KLHDC2 | PHTF2 | 0.725738 | 3 | 0 | 3 |
| KLHDC2 | TADA2B | 0.717679 | 4 | 0 | 3 |
| KLHDC2 | ASTE1 | 0.715258 | 3 | 0 | 3 |
| KLHDC2 | CDC73 | 0.711824 | 4 | 0 | 4 |
| KLHDC2 | IRAK4 | 0.708814 | 3 | 0 | 3 |
| KLHDC2 | NR2C2 | 0.704037 | 4 | 0 | 4 |
For details and further investigation, click here
