| Full name: FA complementation group M | Alias Symbol: FAAP250 | ||
| Type: protein-coding gene | Cytoband: 14q21.2 | ||
| Entrez ID: 57697 | HGNC ID: HGNC:23168 | Ensembl Gene: ENSG00000187790 | OMIM ID: 609644 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FANCM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FANCM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FANCM | 57697 | 234733_s_at | 0.3254 | 0.5744 | |
| GSE26886 | FANCM | 57697 | 231971_at | 0.0093 | 0.9323 | |
| GSE45670 | FANCM | 57697 | 234733_s_at | 0.6079 | 0.0005 | |
| GSE53622 | FANCM | 57697 | 164806 | 0.6932 | 0.0000 | |
| GSE53624 | FANCM | 57697 | 164806 | 0.8008 | 0.0000 | |
| GSE63941 | FANCM | 57697 | 234733_s_at | 0.6771 | 0.3092 | |
| GSE77861 | FANCM | 57697 | 242711_x_at | 0.1598 | 0.5616 | |
| GSE97050 | FANCM | 57697 | A_32_P106732 | 0.3236 | 0.1923 | |
| SRP007169 | FANCM | 57697 | RNAseq | 1.5714 | 0.0052 | |
| SRP008496 | FANCM | 57697 | RNAseq | 1.0722 | 0.0081 | |
| SRP064894 | FANCM | 57697 | RNAseq | 0.6494 | 0.0338 | |
| SRP133303 | FANCM | 57697 | RNAseq | 0.4079 | 0.0264 | |
| SRP159526 | FANCM | 57697 | RNAseq | 0.6107 | 0.1265 | |
| SRP193095 | FANCM | 57697 | RNAseq | 0.4956 | 0.0001 | |
| SRP219564 | FANCM | 57697 | RNAseq | 0.9037 | 0.0147 | |
| TCGA | FANCM | 57697 | RNAseq | 0.3263 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FANCM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FANCM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FANCM | 57697 | 6 | 5 | 19 | |
| GSE20123 | FANCM | 57697 | 6 | 5 | 19 | |
| GSE43470 | FANCM | 57697 | 8 | 3 | 32 | |
| GSE46452 | FANCM | 57697 | 17 | 2 | 40 | |
| GSE47630 | FANCM | 57697 | 11 | 10 | 19 | |
| GSE54993 | FANCM | 57697 | 3 | 9 | 58 | |
| GSE54994 | FANCM | 57697 | 18 | 5 | 30 | |
| GSE60625 | FANCM | 57697 | 0 | 2 | 9 | |
| GSE74703 | FANCM | 57697 | 7 | 3 | 26 | |
| GSE74704 | FANCM | 57697 | 3 | 3 | 14 | |
| TCGA | FANCM | 57697 | 30 | 16 | 50 |
Total number of gains: 109; Total number of losses: 63; Total Number of normals: 316.
Somatic mutations of FANCM:
Generating mutation plots.
Highly correlated genes for FANCM:
Showing top 20/1060 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FANCM | DEPDC4 | 0.750547 | 3 | 0 | 3 |
| FANCM | INO80B | 0.743579 | 3 | 0 | 3 |
| FANCM | RAD51B | 0.739715 | 4 | 0 | 4 |
| FANCM | SLCO1B3 | 0.738572 | 3 | 0 | 3 |
| FANCM | MGAT2 | 0.736388 | 4 | 0 | 4 |
| FANCM | MRPS12 | 0.735834 | 3 | 0 | 3 |
| FANCM | AIMP2 | 0.729944 | 3 | 0 | 3 |
| FANCM | WDHD1 | 0.728302 | 7 | 0 | 7 |
| FANCM | SPDL1 | 0.72678 | 5 | 0 | 5 |
| FANCM | LRR1 | 0.725824 | 6 | 0 | 5 |
| FANCM | WDR89 | 0.725732 | 4 | 0 | 4 |
| FANCM | CCL20 | 0.722139 | 3 | 0 | 3 |
| FANCM | VOPP1 | 0.721469 | 4 | 0 | 4 |
| FANCM | EBNA1BP2 | 0.720886 | 3 | 0 | 3 |
| FANCM | ARL13B | 0.71225 | 3 | 0 | 3 |
| FANCM | FAF2 | 0.710633 | 3 | 0 | 3 |
| FANCM | PDIA4 | 0.708429 | 4 | 0 | 4 |
| FANCM | AJUBA | 0.707899 | 5 | 0 | 4 |
| FANCM | POLA2 | 0.706039 | 4 | 0 | 4 |
| FANCM | YIF1A | 0.705891 | 4 | 0 | 4 |
For details and further investigation, click here
