| Full name: apoptosis resistant E3 ubiquitin protein ligase 1 | Alias Symbol: FIEL1 | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 9870 | HGNC ID: HGNC:20363 | Ensembl Gene: ENSG00000119682 | OMIM ID: 615380 |
| Drug and gene relationship at DGIdb | |||
Expression of AREL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AREL1 | 9870 | 202128_at | 0.5759 | 0.2024 | |
| GSE20347 | AREL1 | 9870 | 202128_at | 0.1447 | 0.3507 | |
| GSE23400 | AREL1 | 9870 | 202128_at | 0.4577 | 0.0000 | |
| GSE26886 | AREL1 | 9870 | 202128_at | -0.7861 | 0.0052 | |
| GSE29001 | AREL1 | 9870 | 202128_at | 0.3434 | 0.0663 | |
| GSE38129 | AREL1 | 9870 | 202128_at | 0.4062 | 0.0019 | |
| GSE45670 | AREL1 | 9870 | 202128_at | 0.5203 | 0.0002 | |
| GSE53622 | AREL1 | 9870 | 7065 | 0.2018 | 0.0079 | |
| GSE53624 | AREL1 | 9870 | 33282 | 0.1821 | 0.0010 | |
| GSE63941 | AREL1 | 9870 | 202128_at | -0.4719 | 0.1721 | |
| GSE77861 | AREL1 | 9870 | 202128_at | 0.3324 | 0.4230 | |
| SRP007169 | AREL1 | 9870 | RNAseq | 0.2633 | 0.4275 | |
| SRP008496 | AREL1 | 9870 | RNAseq | 0.2077 | 0.3132 | |
| SRP064894 | AREL1 | 9870 | RNAseq | 0.3203 | 0.1045 | |
| SRP133303 | AREL1 | 9870 | RNAseq | 0.3716 | 0.0014 | |
| SRP159526 | AREL1 | 9870 | RNAseq | 0.1434 | 0.6239 | |
| SRP193095 | AREL1 | 9870 | RNAseq | 0.0634 | 0.4386 | |
| SRP219564 | AREL1 | 9870 | RNAseq | 0.3991 | 0.3428 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AREL1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of AREL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AREL1 | 9870 | 8 | 3 | 19 | |
| GSE20123 | AREL1 | 9870 | 8 | 3 | 19 | |
| GSE43470 | AREL1 | 9870 | 8 | 3 | 32 | |
| GSE46452 | AREL1 | 9870 | 16 | 3 | 40 | |
| GSE47630 | AREL1 | 9870 | 11 | 8 | 21 | |
| GSE54993 | AREL1 | 9870 | 3 | 8 | 59 | |
| GSE54994 | AREL1 | 9870 | 19 | 4 | 30 | |
| GSE60625 | AREL1 | 9870 | 0 | 2 | 9 | |
| GSE74703 | AREL1 | 9870 | 7 | 3 | 26 | |
| GSE74704 | AREL1 | 9870 | 3 | 3 | 14 | |
| TCGA | AREL1 | 9870 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of AREL1:
Generating mutation plots.
Highly correlated genes for AREL1:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AREL1 | GNPNAT1 | 0.736555 | 3 | 0 | 3 |
| AREL1 | SLC39A9 | 0.699912 | 6 | 0 | 6 |
| AREL1 | RLIM | 0.675826 | 3 | 0 | 3 |
| AREL1 | YY1 | 0.669129 | 7 | 0 | 6 |
| AREL1 | NCOA6 | 0.664844 | 5 | 0 | 5 |
| AREL1 | FGF11 | 0.661802 | 3 | 0 | 3 |
| AREL1 | ATG16L1 | 0.652556 | 3 | 0 | 3 |
| AREL1 | GPD2 | 0.652071 | 3 | 0 | 3 |
| AREL1 | SP140L | 0.645539 | 3 | 0 | 3 |
| AREL1 | TYMS | 0.6432 | 4 | 0 | 3 |
| AREL1 | SND1-IT1 | 0.640903 | 4 | 0 | 3 |
| AREL1 | TDG | 0.633426 | 5 | 0 | 4 |
| AREL1 | PAPOLA | 0.631448 | 6 | 0 | 5 |
| AREL1 | CCNK | 0.628854 | 6 | 0 | 4 |
| AREL1 | TPM3 | 0.625323 | 4 | 0 | 4 |
| AREL1 | C8orf76 | 0.62511 | 4 | 0 | 3 |
| AREL1 | COX16 | 0.62483 | 5 | 0 | 4 |
| AREL1 | SLC5A6 | 0.623335 | 3 | 0 | 3 |
| AREL1 | MARK3 | 0.622312 | 8 | 0 | 8 |
| AREL1 | VRK1 | 0.620976 | 6 | 0 | 4 |
For details and further investigation, click here
