| Full name: neural retina leucine zipper | Alias Symbol: D14S46E|RP27|NRL-MAF | ||
| Type: protein-coding gene | Cytoband: 14q11.2-q12 | ||
| Entrez ID: 4901 | HGNC ID: HGNC:8002 | Ensembl Gene: ENSG00000129535 | OMIM ID: 162080 |
| Drug and gene relationship at DGIdb | |||
Expression of NRL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NRL | 4901 | 206596_s_at | -0.0094 | 0.9828 | |
| GSE20347 | NRL | 4901 | 206596_s_at | -0.0502 | 0.6723 | |
| GSE23400 | NRL | 4901 | 206596_s_at | -0.1207 | 0.0007 | |
| GSE26886 | NRL | 4901 | 206596_s_at | 0.0186 | 0.8990 | |
| GSE29001 | NRL | 4901 | 206596_s_at | -0.1185 | 0.5834 | |
| GSE38129 | NRL | 4901 | 206596_s_at | -0.0399 | 0.6915 | |
| GSE45670 | NRL | 4901 | 206596_s_at | -0.0734 | 0.4521 | |
| GSE53622 | NRL | 4901 | 73935 | 0.2411 | 0.0001 | |
| GSE53624 | NRL | 4901 | 73935 | 0.3501 | 0.0000 | |
| GSE63941 | NRL | 4901 | 206596_s_at | 0.3245 | 0.1884 | |
| GSE77861 | NRL | 4901 | 206596_s_at | -0.0034 | 0.9880 | |
| GSE97050 | NRL | 4901 | A_33_P3423027 | -0.1360 | 0.4621 | |
| SRP133303 | NRL | 4901 | RNAseq | 0.0798 | 0.7783 | |
| SRP159526 | NRL | 4901 | RNAseq | -0.0922 | 0.8333 | |
| SRP193095 | NRL | 4901 | RNAseq | 0.0618 | 0.5973 | |
| SRP219564 | NRL | 4901 | RNAseq | 0.1956 | 0.6136 | |
| TCGA | NRL | 4901 | RNAseq | 0.0269 | 0.8761 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NRL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NRL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NRL | 4901 | 8 | 3 | 19 | |
| GSE20123 | NRL | 4901 | 8 | 3 | 19 | |
| GSE43470 | NRL | 4901 | 8 | 2 | 33 | |
| GSE46452 | NRL | 4901 | 16 | 2 | 41 | |
| GSE47630 | NRL | 4901 | 11 | 10 | 19 | |
| GSE54993 | NRL | 4901 | 3 | 11 | 56 | |
| GSE54994 | NRL | 4901 | 18 | 5 | 30 | |
| GSE60625 | NRL | 4901 | 0 | 2 | 9 | |
| GSE74703 | NRL | 4901 | 7 | 2 | 27 | |
| GSE74704 | NRL | 4901 | 3 | 2 | 15 | |
| TCGA | NRL | 4901 | 27 | 13 | 56 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of NRL:
Generating mutation plots.
Highly correlated genes for NRL:
Showing top 20/336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NRL | SLC26A5 | 0.806 | 3 | 0 | 3 |
| NRL | KRTAP12-2 | 0.803525 | 3 | 0 | 3 |
| NRL | INPP5E | 0.786569 | 3 | 0 | 3 |
| NRL | OR2T33 | 0.770465 | 3 | 0 | 3 |
| NRL | ALG11 | 0.767594 | 3 | 0 | 3 |
| NRL | WIZ | 0.75745 | 3 | 0 | 3 |
| NRL | R3HDM2 | 0.75686 | 3 | 0 | 3 |
| NRL | SPEG | 0.746015 | 3 | 0 | 3 |
| NRL | SZT2 | 0.742721 | 6 | 0 | 6 |
| NRL | LENG8 | 0.742444 | 3 | 0 | 3 |
| NRL | HDAC11 | 0.73979 | 4 | 0 | 4 |
| NRL | OR1L6 | 0.7365 | 3 | 0 | 3 |
| NRL | PLXNB1 | 0.73029 | 3 | 0 | 3 |
| NRL | JUND | 0.726899 | 3 | 0 | 3 |
| NRL | KLHL33 | 0.724858 | 3 | 0 | 3 |
| NRL | PIP5K1C | 0.723583 | 3 | 0 | 3 |
| NRL | PRR23C | 0.722609 | 3 | 0 | 3 |
| NRL | MDFI | 0.719971 | 4 | 0 | 4 |
| NRL | OR2T12 | 0.711864 | 3 | 0 | 3 |
| NRL | RBM17 | 0.711429 | 5 | 0 | 4 |
For details and further investigation, click here
