NTF3

 

Full name: neurotrophin 3 Alias Symbol: NGF2
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 4908 HGNC ID: HGNC:8023 Ensembl Gene: ENSG00000185652 OMIM ID: 162660
Drug and gene relationship at DGIdb

 

NTF3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway

 

Expression of NTF3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NTF3 4908 206706_at -0.6035 0.1185
GSE20347 NTF3 4908 206706_at -0.2152 0.1723
GSE23400 NTF3 4908 206706_at -0.1343 0.0021
GSE26886 NTF3 4908 206706_at 0.0447 0.9170
GSE29001 NTF3 4908 206706_at -0.0837 0.8082
GSE38129 NTF3 4908 206706_at -0.3833 0.0048
GSE45670 NTF3 4908 206706_at -0.5193 0.0007
GSE53622 NTF3 4908 162109 -0.5475 0.0000
GSE53624 NTF3 4908 162109 -0.7566 0.0000
GSE63941 NTF3 4908 206706_at 0.4408 0.6078
GSE77861 NTF3 4908 206706_at 0.1255 0.5157
GSE97050 NTF3 4908 A_23_P360797 -0.1223 0.7777
SRP064894 NTF3 4908 RNAseq -1.5402 0.0006
SRP133303 NTF3 4908 RNAseq -2.5115 0.0000
SRP159526 NTF3 4908 RNAseq -0.2129 0.7663
TCGA NTF3 4908 RNAseq -0.8074 0.0694

Upregulated datasets: 0; Downregulated datasets: 2.  


 

Survival by NTF3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of NTF3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NTF3 4908 6 4 20
GSE20123 NTF3 4908 6 4 20
GSE43470 NTF3 4908 9 3 31
GSE46452 NTF3 4908 10 1 48
GSE47630 NTF3 4908 12 2 26
GSE54993 NTF3 4908 1 10 59
GSE54994 NTF3 4908 10 2 41
GSE60625 NTF3 4908 0 1 10
GSE74703 NTF3 4908 8 2 26
GSE74704 NTF3 4908 4 2 14
TCGA NTF3 4908 40 6 50

Total number of gains: 106; Total number of losses: 37; Total Number of normals: 345.  


 

Somatic mutations of NTF3:

 

Generating mutation plots.

 

Highly correlated genes for NTF3:

 

Showing top 20/71 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NTF3FAM71F10.732501303
NTF3LINC009240.679222303
NTF3PHF21B0.673612303
NTF3IGSF220.639632303
NTF3CTTNBP20.639591505
NTF3SHROOM40.63958403
NTF3GRIK50.637684303
NTF3RANBP30.633389303
NTF3KIAA16710.627968303
NTF3CDK5R20.626137303
NTF3CNTN40.621096303
NTF3ADAP10.620511403
NTF3ZNF7630.613823303
NTF3C16orf890.613068403
NTF3WDR60.606905403
NTF3BRAF0.605637403
NTF3IRX10.60464303
NTF3LRRC20.602689403
NTF3LDB20.602532403
NTF3SLC22A140.601292504

For details and further investigation, click here