| Full name: RasGEF domain family member 1A | Alias Symbol: CG4853|FLJ37817 | ||
| Type: protein-coding gene | Cytoband: 10q11.21 | ||
| Entrez ID: 221002 | HGNC ID: HGNC:24246 | Ensembl Gene: ENSG00000198915 | OMIM ID: 614531 |
| Drug and gene relationship at DGIdb | |||
Expression of RASGEF1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASGEF1A | 221002 | 230563_at | 1.1046 | 0.2903 | |
| GSE26886 | RASGEF1A | 221002 | 230563_at | 2.0419 | 0.0031 | |
| GSE45670 | RASGEF1A | 221002 | 230563_at | -0.2362 | 0.6475 | |
| GSE53622 | RASGEF1A | 221002 | 45705 | 0.0733 | 0.7150 | |
| GSE53624 | RASGEF1A | 221002 | 45705 | 0.8819 | 0.0000 | |
| GSE63941 | RASGEF1A | 221002 | 230563_at | 1.0062 | 0.5481 | |
| GSE77861 | RASGEF1A | 221002 | 242917_at | -0.0589 | 0.6472 | |
| GSE97050 | RASGEF1A | 221002 | A_32_P223140 | 0.1118 | 0.7392 | |
| SRP007169 | RASGEF1A | 221002 | RNAseq | 0.0098 | 0.9873 | |
| SRP008496 | RASGEF1A | 221002 | RNAseq | 0.8563 | 0.0424 | |
| SRP064894 | RASGEF1A | 221002 | RNAseq | 0.4169 | 0.2819 | |
| SRP133303 | RASGEF1A | 221002 | RNAseq | 1.0176 | 0.0549 | |
| SRP159526 | RASGEF1A | 221002 | RNAseq | 0.3468 | 0.5919 | |
| SRP193095 | RASGEF1A | 221002 | RNAseq | 1.9297 | 0.0000 | |
| SRP219564 | RASGEF1A | 221002 | RNAseq | 0.3628 | 0.5779 | |
| TCGA | RASGEF1A | 221002 | RNAseq | 0.7632 | 0.0217 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RASGEF1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASGEF1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASGEF1A | 221002 | 2 | 6 | 22 | |
| GSE20123 | RASGEF1A | 221002 | 3 | 5 | 22 | |
| GSE43470 | RASGEF1A | 221002 | 1 | 6 | 36 | |
| GSE46452 | RASGEF1A | 221002 | 0 | 13 | 46 | |
| GSE47630 | RASGEF1A | 221002 | 4 | 12 | 24 | |
| GSE54993 | RASGEF1A | 221002 | 9 | 0 | 61 | |
| GSE54994 | RASGEF1A | 221002 | 2 | 10 | 41 | |
| GSE60625 | RASGEF1A | 221002 | 0 | 0 | 11 | |
| GSE74703 | RASGEF1A | 221002 | 1 | 3 | 32 | |
| GSE74704 | RASGEF1A | 221002 | 2 | 4 | 14 | |
| TCGA | RASGEF1A | 221002 | 16 | 19 | 61 |
Total number of gains: 40; Total number of losses: 78; Total Number of normals: 370.
Somatic mutations of RASGEF1A:
Generating mutation plots.
Highly correlated genes for RASGEF1A:
Showing top 20/67 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASGEF1A | HSPBAP1 | 0.785663 | 3 | 0 | 3 |
| RASGEF1A | PGP | 0.75756 | 3 | 0 | 3 |
| RASGEF1A | CLCN2 | 0.722162 | 3 | 0 | 3 |
| RASGEF1A | RPP25 | 0.71088 | 3 | 0 | 3 |
| RASGEF1A | MEX3D | 0.705246 | 3 | 0 | 3 |
| RASGEF1A | TBCCD1 | 0.701832 | 3 | 0 | 3 |
| RASGEF1A | SYT8 | 0.699843 | 3 | 0 | 3 |
| RASGEF1A | NTHL1 | 0.698788 | 3 | 0 | 3 |
| RASGEF1A | C7orf26 | 0.696218 | 3 | 0 | 3 |
| RASGEF1A | NPW | 0.69271 | 3 | 0 | 3 |
| RASGEF1A | HSF2BP | 0.692435 | 3 | 0 | 3 |
| RASGEF1A | WRAP73 | 0.691432 | 3 | 0 | 3 |
| RASGEF1A | ZNF639 | 0.687744 | 3 | 0 | 3 |
| RASGEF1A | GPATCH3 | 0.675612 | 3 | 0 | 3 |
| RASGEF1A | ZNF205 | 0.667913 | 4 | 0 | 3 |
| RASGEF1A | ZNF48 | 0.666719 | 3 | 0 | 3 |
| RASGEF1A | CCDC57 | 0.664616 | 3 | 0 | 3 |
| RASGEF1A | SRCAP | 0.664567 | 3 | 0 | 3 |
| RASGEF1A | KAT2A | 0.664492 | 4 | 0 | 3 |
| RASGEF1A | MIB2 | 0.658048 | 4 | 0 | 3 |
For details and further investigation, click here
