| Full name: DNA topoisomerase II beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p24.2 | ||
| Entrez ID: 7155 | HGNC ID: HGNC:11990 | Ensembl Gene: ENSG00000077097 | OMIM ID: 126431 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TOP2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOP2B | 7155 | 211987_at | -0.1231 | 0.7970 | |
| GSE20347 | TOP2B | 7155 | 211987_at | -0.5568 | 0.0023 | |
| GSE23400 | TOP2B | 7155 | 211987_at | -0.2090 | 0.0145 | |
| GSE26886 | TOP2B | 7155 | 211987_at | -0.3747 | 0.0450 | |
| GSE29001 | TOP2B | 7155 | 211987_at | -0.2322 | 0.3794 | |
| GSE38129 | TOP2B | 7155 | 211987_at | -0.4704 | 0.0001 | |
| GSE45670 | TOP2B | 7155 | 211987_at | -0.4332 | 0.0137 | |
| GSE53622 | TOP2B | 7155 | 18074 | -0.5495 | 0.0000 | |
| GSE53624 | TOP2B | 7155 | 18074 | -0.5623 | 0.0000 | |
| GSE63941 | TOP2B | 7155 | 211987_at | -0.3940 | 0.3972 | |
| GSE77861 | TOP2B | 7155 | 211987_at | -0.5536 | 0.0830 | |
| GSE97050 | TOP2B | 7155 | A_23_P121095 | -0.5977 | 0.0835 | |
| SRP007169 | TOP2B | 7155 | RNAseq | 0.4500 | 0.2807 | |
| SRP008496 | TOP2B | 7155 | RNAseq | 0.9573 | 0.0013 | |
| SRP064894 | TOP2B | 7155 | RNAseq | -0.6172 | 0.0002 | |
| SRP133303 | TOP2B | 7155 | RNAseq | -0.2434 | 0.2609 | |
| SRP159526 | TOP2B | 7155 | RNAseq | -0.2808 | 0.1766 | |
| SRP193095 | TOP2B | 7155 | RNAseq | -0.6237 | 0.0000 | |
| SRP219564 | TOP2B | 7155 | RNAseq | -0.7061 | 0.0308 | |
| TCGA | TOP2B | 7155 | RNAseq | -0.1341 | 0.0087 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TOP2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOP2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOP2B | 7155 | 0 | 18 | 12 | |
| GSE20123 | TOP2B | 7155 | 0 | 18 | 12 | |
| GSE43470 | TOP2B | 7155 | 0 | 20 | 23 | |
| GSE46452 | TOP2B | 7155 | 2 | 17 | 40 | |
| GSE47630 | TOP2B | 7155 | 1 | 24 | 15 | |
| GSE54993 | TOP2B | 7155 | 6 | 2 | 62 | |
| GSE54994 | TOP2B | 7155 | 1 | 32 | 20 | |
| GSE60625 | TOP2B | 7155 | 5 | 0 | 6 | |
| GSE74703 | TOP2B | 7155 | 0 | 17 | 19 | |
| GSE74704 | TOP2B | 7155 | 0 | 12 | 8 | |
| TCGA | TOP2B | 7155 | 1 | 68 | 27 |
Total number of gains: 16; Total number of losses: 228; Total Number of normals: 244.
Somatic mutations of TOP2B:
Generating mutation plots.
Highly correlated genes for TOP2B:
Showing top 20/1041 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOP2B | KBTBD4 | 0.76543 | 3 | 0 | 3 |
| TOP2B | NUB1 | 0.762294 | 3 | 0 | 3 |
| TOP2B | TPRG1L | 0.752933 | 3 | 0 | 3 |
| TOP2B | PGRMC1 | 0.735544 | 3 | 0 | 3 |
| TOP2B | ZNF480 | 0.730911 | 3 | 0 | 3 |
| TOP2B | RREB1 | 0.725023 | 3 | 0 | 3 |
| TOP2B | HNRNPH2 | 0.721335 | 3 | 0 | 3 |
| TOP2B | ZNF253 | 0.715127 | 4 | 0 | 4 |
| TOP2B | ARL5A | 0.705001 | 3 | 0 | 3 |
| TOP2B | TMCO4 | 0.70437 | 4 | 0 | 4 |
| TOP2B | ZNF708 | 0.700584 | 3 | 0 | 3 |
| TOP2B | CMC1 | 0.69788 | 3 | 0 | 3 |
| TOP2B | SACM1L | 0.696926 | 11 | 0 | 10 |
| TOP2B | EIF2B1 | 0.695129 | 4 | 0 | 4 |
| TOP2B | XPC | 0.693809 | 5 | 0 | 4 |
| TOP2B | SLC35B3 | 0.692678 | 5 | 0 | 4 |
| TOP2B | WTAP | 0.691837 | 3 | 0 | 3 |
| TOP2B | GLTP | 0.691254 | 3 | 0 | 3 |
| TOP2B | ZNF704 | 0.691138 | 4 | 0 | 3 |
| TOP2B | ZNRD1 | 0.691131 | 3 | 0 | 3 |
For details and further investigation, click here
