NUP50

 

Full name: nucleoporin 50 Alias Symbol: 
Type: protein-coding gene Cytoband: 22q13.31
Entrez ID: 10762 HGNC ID: HGNC:8065 Ensembl Gene: ENSG00000093000 OMIM ID: 604646
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of NUP50:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NUP50 10762 213682_at 0.1980 0.7120
GSE20347 NUP50 10762 213682_at 0.1103 0.5398
GSE23400 NUP50 10762 213682_at 0.4159 0.0000
GSE26886 NUP50 10762 213682_at 0.1112 0.5801
GSE29001 NUP50 10762 213682_at 0.1851 0.5120
GSE38129 NUP50 10762 213682_at 0.3708 0.0190
GSE45670 NUP50 10762 213682_at 0.5200 0.0003
GSE53622 NUP50 10762 60292 0.5164 0.0000
GSE53624 NUP50 10762 60292 0.7128 0.0000
GSE63941 NUP50 10762 213682_at 0.0184 0.9611
GSE77861 NUP50 10762 213682_at 0.1975 0.5495
GSE97050 NUP50 10762 A_23_P211627 0.8256 0.1449
SRP007169 NUP50 10762 RNAseq 0.9612 0.0093
SRP008496 NUP50 10762 RNAseq 0.7686 0.0033
SRP064894 NUP50 10762 RNAseq 0.3577 0.0886
SRP133303 NUP50 10762 RNAseq 0.4133 0.0049
SRP159526 NUP50 10762 RNAseq 0.1777 0.4031
SRP193095 NUP50 10762 RNAseq 0.0416 0.6674
SRP219564 NUP50 10762 RNAseq 0.1294 0.8160
TCGA NUP50 10762 RNAseq 0.0452 0.3215

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NUP50 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NUP50:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NUP50 10762 4 7 19
GSE20123 NUP50 10762 4 6 20
GSE43470 NUP50 10762 2 6 35
GSE46452 NUP50 10762 31 2 26
GSE47630 NUP50 10762 9 4 27
GSE54993 NUP50 10762 3 6 61
GSE54994 NUP50 10762 11 7 35
GSE60625 NUP50 10762 5 0 6
GSE74703 NUP50 10762 2 4 30
GSE74704 NUP50 10762 1 3 16
TCGA NUP50 10762 27 15 54

Total number of gains: 99; Total number of losses: 60; Total Number of normals: 329.  

 

Somatic mutations of NUP50:

 

Generating mutation plots.

 

Highly correlated genes for NUP50:

 

Showing top 20/786 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NUP50CDC1230.801274303
NUP50PIGS0.780368303
NUP50MRPL370.776423303
NUP50C8orf760.755516303
NUP50ITFG10.745651303
NUP50SLC30A70.730231404
NUP50POGLUT10.727118303
NUP50ACBD50.716242303
NUP50ZNF7640.710196303
NUP50THAP110.704314403
NUP50SPNS10.702173303
NUP50POLR2C0.701853403
NUP50HSD17B120.699438303
NUP50MAD2L1BP0.696639505
NUP50VPS33A0.692699403
NUP50TMED40.686787303
NUP50THAP100.685028303
NUP50SLC35B10.684449605
NUP50PFDN20.683185404
NUP50PRCC0.682739303

For details and further investigation, click here