| Full name: transmembrane p24 trafficking protein 4 | Alias Symbol: HNLF|p24alpha3|p24a3 | ||
| Type: protein-coding gene | Cytoband: 7p13 | ||
| Entrez ID: 222068 | HGNC ID: HGNC:22301 | Ensembl Gene: ENSG00000158604 | OMIM ID: 612038 |
| Drug and gene relationship at DGIdb | |||
Expression of TMED4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMED4 | 222068 | 224680_at | -0.0521 | 0.9145 | |
| GSE26886 | TMED4 | 222068 | 224680_at | 0.1813 | 0.4789 | |
| GSE45670 | TMED4 | 222068 | 224680_at | -0.0783 | 0.5457 | |
| GSE53622 | TMED4 | 222068 | 55932 | 0.2233 | 0.0004 | |
| GSE53624 | TMED4 | 222068 | 55932 | 0.1822 | 0.0009 | |
| GSE63941 | TMED4 | 222068 | 224676_at | 2.1480 | 0.0010 | |
| GSE77861 | TMED4 | 222068 | 224680_at | -0.1980 | 0.3819 | |
| GSE97050 | TMED4 | 222068 | A_24_P163537 | 0.0635 | 0.8503 | |
| SRP007169 | TMED4 | 222068 | RNAseq | -0.7324 | 0.0281 | |
| SRP008496 | TMED4 | 222068 | RNAseq | -0.2123 | 0.3476 | |
| SRP064894 | TMED4 | 222068 | RNAseq | 0.0908 | 0.4212 | |
| SRP133303 | TMED4 | 222068 | RNAseq | 0.1836 | 0.0434 | |
| SRP159526 | TMED4 | 222068 | RNAseq | 0.5438 | 0.0002 | |
| SRP193095 | TMED4 | 222068 | RNAseq | -0.1270 | 0.3307 | |
| SRP219564 | TMED4 | 222068 | RNAseq | -0.1778 | 0.4378 | |
| TCGA | TMED4 | 222068 | RNAseq | -0.1236 | 0.0101 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TMED4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMED4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMED4 | 222068 | 13 | 0 | 17 | |
| GSE20123 | TMED4 | 222068 | 13 | 0 | 17 | |
| GSE43470 | TMED4 | 222068 | 4 | 0 | 39 | |
| GSE46452 | TMED4 | 222068 | 11 | 1 | 47 | |
| GSE47630 | TMED4 | 222068 | 8 | 1 | 31 | |
| GSE54993 | TMED4 | 222068 | 0 | 8 | 62 | |
| GSE54994 | TMED4 | 222068 | 16 | 3 | 34 | |
| GSE60625 | TMED4 | 222068 | 0 | 0 | 11 | |
| GSE74703 | TMED4 | 222068 | 4 | 0 | 32 | |
| GSE74704 | TMED4 | 222068 | 7 | 0 | 13 | |
| TCGA | TMED4 | 222068 | 50 | 7 | 39 |
Total number of gains: 126; Total number of losses: 20; Total Number of normals: 342.
Somatic mutations of TMED4:
Generating mutation plots.
Highly correlated genes for TMED4:
Showing top 20/126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMED4 | C1orf43 | 0.761415 | 3 | 0 | 3 |
| TMED4 | ZNF207 | 0.758815 | 3 | 0 | 3 |
| TMED4 | OGDH | 0.755774 | 3 | 0 | 3 |
| TMED4 | PSMD4 | 0.748304 | 3 | 0 | 3 |
| TMED4 | RRNAD1 | 0.741202 | 3 | 0 | 3 |
| TMED4 | ANAPC16 | 0.738175 | 3 | 0 | 3 |
| TMED4 | C1GALT1C1 | 0.737549 | 3 | 0 | 3 |
| TMED4 | WDR61 | 0.735353 | 3 | 0 | 3 |
| TMED4 | CNOT1 | 0.734235 | 3 | 0 | 3 |
| TMED4 | COPZ1 | 0.731953 | 4 | 0 | 4 |
| TMED4 | SLC18A2 | 0.7305 | 3 | 0 | 3 |
| TMED4 | SEMA4D | 0.724526 | 3 | 0 | 3 |
| TMED4 | SCAMP3 | 0.720373 | 3 | 0 | 3 |
| TMED4 | GABPA | 0.714437 | 3 | 0 | 3 |
| TMED4 | OS9 | 0.714331 | 3 | 0 | 3 |
| TMED4 | ZNF691 | 0.708661 | 3 | 0 | 3 |
| TMED4 | SORL1 | 0.695955 | 4 | 0 | 3 |
| TMED4 | COX5A | 0.692907 | 4 | 0 | 4 |
| TMED4 | DPH5 | 0.687914 | 3 | 0 | 3 |
| TMED4 | NUP50 | 0.686787 | 3 | 0 | 3 |
For details and further investigation, click here
