| Full name: hydroxysteroid 17-beta dehydrogenase 12 | Alias Symbol: KAR|SDR12C1 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 51144 | HGNC ID: HGNC:18646 | Ensembl Gene: ENSG00000149084 | OMIM ID: 609574 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HSD17B12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B12 | 51144 | 217869_at | 0.0121 | 0.9853 | |
| GSE20347 | HSD17B12 | 51144 | 217869_at | -0.3163 | 0.0764 | |
| GSE23400 | HSD17B12 | 51144 | 217869_at | 0.0800 | 0.3567 | |
| GSE26886 | HSD17B12 | 51144 | 217869_at | -0.1194 | 0.5917 | |
| GSE29001 | HSD17B12 | 51144 | 217869_at | -0.1559 | 0.7037 | |
| GSE38129 | HSD17B12 | 51144 | 217869_at | -0.2408 | 0.1079 | |
| GSE45670 | HSD17B12 | 51144 | 217869_at | -0.0319 | 0.8512 | |
| GSE53622 | HSD17B12 | 51144 | 13317 | -0.2273 | 0.0033 | |
| GSE53624 | HSD17B12 | 51144 | 13317 | -0.1462 | 0.0116 | |
| GSE63941 | HSD17B12 | 51144 | 217869_at | -0.5155 | 0.4208 | |
| GSE77861 | HSD17B12 | 51144 | 217869_at | 0.1796 | 0.6205 | |
| GSE97050 | HSD17B12 | 51144 | A_33_P3335042 | -0.0152 | 0.9691 | |
| SRP007169 | HSD17B12 | 51144 | RNAseq | -0.2034 | 0.6857 | |
| SRP008496 | HSD17B12 | 51144 | RNAseq | -0.2298 | 0.4472 | |
| SRP064894 | HSD17B12 | 51144 | RNAseq | -0.2787 | 0.1445 | |
| SRP133303 | HSD17B12 | 51144 | RNAseq | 0.3580 | 0.1007 | |
| SRP159526 | HSD17B12 | 51144 | RNAseq | -0.2978 | 0.3955 | |
| SRP193095 | HSD17B12 | 51144 | RNAseq | -0.4703 | 0.0006 | |
| SRP219564 | HSD17B12 | 51144 | RNAseq | -0.2038 | 0.5158 | |
| TCGA | HSD17B12 | 51144 | RNAseq | -0.1854 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSD17B12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B12 | 51144 | 2 | 7 | 21 | |
| GSE20123 | HSD17B12 | 51144 | 2 | 6 | 22 | |
| GSE43470 | HSD17B12 | 51144 | 3 | 4 | 36 | |
| GSE46452 | HSD17B12 | 51144 | 8 | 5 | 46 | |
| GSE47630 | HSD17B12 | 51144 | 3 | 9 | 28 | |
| GSE54993 | HSD17B12 | 51144 | 3 | 0 | 67 | |
| GSE54994 | HSD17B12 | 51144 | 2 | 10 | 41 | |
| GSE60625 | HSD17B12 | 51144 | 0 | 0 | 11 | |
| GSE74703 | HSD17B12 | 51144 | 2 | 2 | 32 | |
| GSE74704 | HSD17B12 | 51144 | 2 | 5 | 13 | |
| TCGA | HSD17B12 | 51144 | 13 | 21 | 62 |
Total number of gains: 40; Total number of losses: 69; Total Number of normals: 379.
Somatic mutations of HSD17B12:
Generating mutation plots.
Highly correlated genes for HSD17B12:
Showing top 20/240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B12 | MFN1 | 0.779734 | 3 | 0 | 3 |
| HSD17B12 | SEC24B | 0.74974 | 3 | 0 | 3 |
| HSD17B12 | NAPG | 0.742784 | 3 | 0 | 3 |
| HSD17B12 | RPE | 0.731699 | 3 | 0 | 3 |
| HSD17B12 | INTS4 | 0.726607 | 3 | 0 | 3 |
| HSD17B12 | STX4 | 0.711314 | 3 | 0 | 3 |
| HSD17B12 | IWS1 | 0.705552 | 3 | 0 | 3 |
| HSD17B12 | LY75 | 0.703042 | 3 | 0 | 3 |
| HSD17B12 | NUP50 | 0.699438 | 3 | 0 | 3 |
| HSD17B12 | TRIM5 | 0.698618 | 3 | 0 | 3 |
| HSD17B12 | EIF2A | 0.694527 | 3 | 0 | 3 |
| HSD17B12 | UBA2 | 0.694481 | 3 | 0 | 3 |
| HSD17B12 | TMEM43 | 0.693099 | 3 | 0 | 3 |
| HSD17B12 | GTF3C6 | 0.688992 | 4 | 0 | 3 |
| HSD17B12 | PAK1 | 0.687708 | 3 | 0 | 3 |
| HSD17B12 | NAV2 | 0.685263 | 3 | 0 | 3 |
| HSD17B12 | USP32 | 0.684543 | 4 | 0 | 3 |
| HSD17B12 | TMEM69 | 0.684067 | 3 | 0 | 3 |
| HSD17B12 | RB1 | 0.683225 | 3 | 0 | 3 |
| HSD17B12 | LARP7 | 0.681323 | 4 | 0 | 3 |
For details and further investigation, click here
