NXT1

 

Full name: nuclear transport factor 2 like export factor 1 Alias Symbol: P15|MTR2
Type: protein-coding gene Cytoband: 20p11.21
Entrez ID: 29107 HGNC ID: HGNC:15913 Ensembl Gene: ENSG00000132661 OMIM ID: 605811
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of NXT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NXT1 29107 218708_at 1.1146 0.0621
GSE20347 NXT1 29107 218708_at 0.7727 0.0000
GSE23400 NXT1 29107 218708_at 0.5509 0.0000
GSE26886 NXT1 29107 218708_at 1.2997 0.0000
GSE29001 NXT1 29107 218708_at 0.7113 0.0050
GSE38129 NXT1 29107 218708_at 0.7843 0.0000
GSE45670 NXT1 29107 218708_at 0.3923 0.0338
GSE53622 NXT1 29107 5669 0.6537 0.0000
GSE53624 NXT1 29107 5669 0.7995 0.0000
GSE63941 NXT1 29107 218708_at 0.9829 0.0450
GSE77861 NXT1 29107 218708_at 0.6004 0.0149
GSE97050 NXT1 29107 A_23_P251695 0.5722 0.1932
SRP007169 NXT1 29107 RNAseq 0.2788 0.5709
SRP008496 NXT1 29107 RNAseq 0.4713 0.1687
SRP064894 NXT1 29107 RNAseq 0.7384 0.0196
SRP133303 NXT1 29107 RNAseq 0.6015 0.0001
SRP159526 NXT1 29107 RNAseq 0.7873 0.0220
SRP193095 NXT1 29107 RNAseq 0.4223 0.0057
SRP219564 NXT1 29107 RNAseq 0.9653 0.0253
TCGA NXT1 29107 RNAseq 0.3256 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by NXT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NXT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NXT1 29107 13 1 16
GSE20123 NXT1 29107 13 1 16
GSE43470 NXT1 29107 11 1 31
GSE46452 NXT1 29107 27 1 31
GSE47630 NXT1 29107 17 4 19
GSE54993 NXT1 29107 0 17 53
GSE54994 NXT1 29107 26 2 25
GSE60625 NXT1 29107 0 0 11
GSE74703 NXT1 29107 9 1 26
GSE74704 NXT1 29107 7 1 12
TCGA NXT1 29107 42 11 43

Total number of gains: 165; Total number of losses: 40; Total Number of normals: 283.  

 

Somatic mutations of NXT1:

 

Generating mutation plots.

 

Highly correlated genes for NXT1:

 

Showing top 20/1955 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NXT1ZNF7070.78925303
NXT1SNRPB20.78355412012
NXT1FHL30.781767303
NXT1MRPS260.766392808
NXT1NOP560.764535303
NXT1TMEM63B0.756105303
NXT1SSBP40.750899404
NXT1TEAD20.750614404
NXT1APMAP0.74890210010
NXT1CTU20.746869505
NXT1FYN0.74372303
NXT1NAA380.74243404
NXT1ZNF2510.737908303
NXT1GINS10.73247912011
NXT1SLC41A10.730044706
NXT1WDR540.7299505
NXT1MMS22L0.727021303
NXT1TRMT60.726419908
NXT1SBK10.72618303
NXT1SLC25A320.72609311011

For details and further investigation, click here