| Full name: cytosolic thiouridylase subunit 2 | Alias Symbol: NCS2 | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 348180 | HGNC ID: HGNC:28005 | Ensembl Gene: ENSG00000174177 | OMIM ID: 617057 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CTU2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CTU2 | 348180 | 226410_at | 0.6353 | 0.0308 | |
| GSE26886 | CTU2 | 348180 | 226410_at | 1.1750 | 0.0000 | |
| GSE45670 | CTU2 | 348180 | 226410_at | 0.2747 | 0.0317 | |
| GSE53622 | CTU2 | 348180 | 143039 | 0.5314 | 0.0000 | |
| GSE53624 | CTU2 | 348180 | 143039 | 0.7292 | 0.0000 | |
| GSE63941 | CTU2 | 348180 | 226410_at | -0.3537 | 0.4419 | |
| GSE77861 | CTU2 | 348180 | 226410_at | 0.0708 | 0.6717 | |
| GSE97050 | CTU2 | 348180 | A_24_P118247 | 0.4557 | 0.2318 | |
| SRP007169 | CTU2 | 348180 | RNAseq | 0.2260 | 0.6068 | |
| SRP008496 | CTU2 | 348180 | RNAseq | 0.4831 | 0.1742 | |
| SRP064894 | CTU2 | 348180 | RNAseq | 0.4234 | 0.1195 | |
| SRP133303 | CTU2 | 348180 | RNAseq | 0.8880 | 0.0007 | |
| SRP159526 | CTU2 | 348180 | RNAseq | 1.0081 | 0.0335 | |
| SRP193095 | CTU2 | 348180 | RNAseq | 0.4541 | 0.0001 | |
| SRP219564 | CTU2 | 348180 | RNAseq | 0.3181 | 0.3511 | |
| TCGA | CTU2 | 348180 | RNAseq | 0.1610 | 0.0253 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CTU2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CTU2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CTU2 | 348180 | 4 | 3 | 23 | |
| GSE20123 | CTU2 | 348180 | 4 | 3 | 23 | |
| GSE43470 | CTU2 | 348180 | 1 | 13 | 29 | |
| GSE46452 | CTU2 | 348180 | 38 | 1 | 20 | |
| GSE47630 | CTU2 | 348180 | 11 | 9 | 20 | |
| GSE54993 | CTU2 | 348180 | 3 | 4 | 63 | |
| GSE54994 | CTU2 | 348180 | 9 | 11 | 33 | |
| GSE60625 | CTU2 | 348180 | 4 | 0 | 7 | |
| GSE74703 | CTU2 | 348180 | 1 | 9 | 26 | |
| GSE74704 | CTU2 | 348180 | 3 | 2 | 15 | |
| TCGA | CTU2 | 348180 | 28 | 15 | 53 |
Total number of gains: 106; Total number of losses: 70; Total Number of normals: 312.
Somatic mutations of CTU2:
Generating mutation plots.
Highly correlated genes for CTU2:
Showing top 20/1681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CTU2 | SFR1 | 0.818933 | 3 | 0 | 3 |
| CTU2 | ROMO1 | 0.814978 | 3 | 0 | 3 |
| CTU2 | MMP15 | 0.78336 | 3 | 0 | 3 |
| CTU2 | GPR153 | 0.78201 | 3 | 0 | 3 |
| CTU2 | IMP4 | 0.776458 | 6 | 0 | 6 |
| CTU2 | PTRH2 | 0.764287 | 6 | 0 | 6 |
| CTU2 | PLCG1 | 0.762841 | 3 | 0 | 3 |
| CTU2 | EEF1E1 | 0.750821 | 3 | 0 | 3 |
| CTU2 | DSCC1 | 0.749913 | 4 | 0 | 4 |
| CTU2 | KTI12 | 0.748745 | 3 | 0 | 3 |
| CTU2 | NXT1 | 0.746869 | 5 | 0 | 5 |
| CTU2 | WDHD1 | 0.745871 | 6 | 0 | 6 |
| CTU2 | RUVBL1 | 0.745126 | 6 | 0 | 6 |
| CTU2 | SLC25A32 | 0.743742 | 6 | 0 | 6 |
| CTU2 | CCDC86 | 0.743501 | 4 | 0 | 3 |
| CTU2 | FARS2 | 0.743024 | 3 | 0 | 3 |
| CTU2 | RAD54L | 0.741523 | 4 | 0 | 4 |
| CTU2 | FEZ1 | 0.739928 | 3 | 0 | 3 |
| CTU2 | CMC2 | 0.739582 | 6 | 0 | 6 |
| CTU2 | KHSRP | 0.738761 | 4 | 0 | 4 |
For details and further investigation, click here
