| Full name: OCA2 melanosomal transmembrane protein | Alias Symbol: BEY2|EYCL|BEY|BEY1 | ||
| Type: protein-coding gene | Cytoband: 15q12-q13.1 | ||
| Entrez ID: 4948 | HGNC ID: HGNC:8101 | Ensembl Gene: ENSG00000104044 | OMIM ID: 611409 |
| Drug and gene relationship at DGIdb | |||
Expression of OCA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OCA2 | 4948 | 206498_at | -0.7649 | 0.0725 | |
| GSE20347 | OCA2 | 4948 | 206498_at | -0.5932 | 0.0200 | |
| GSE23400 | OCA2 | 4948 | 206498_at | -0.2755 | 0.0000 | |
| GSE26886 | OCA2 | 4948 | 206498_at | -1.5574 | 0.0000 | |
| GSE29001 | OCA2 | 4948 | 206498_at | -0.8981 | 0.0601 | |
| GSE38129 | OCA2 | 4948 | 206498_at | -0.4048 | 0.1020 | |
| GSE45670 | OCA2 | 4948 | 206498_at | -0.8447 | 0.0116 | |
| GSE53622 | OCA2 | 4948 | 102162 | -1.1986 | 0.0000 | |
| GSE53624 | OCA2 | 4948 | 91207 | -2.9002 | 0.0000 | |
| GSE63941 | OCA2 | 4948 | 206498_at | 0.4394 | 0.0016 | |
| GSE77861 | OCA2 | 4948 | 206498_at | -0.4861 | 0.0523 | |
| SRP064894 | OCA2 | 4948 | RNAseq | -2.4959 | 0.0000 | |
| SRP133303 | OCA2 | 4948 | RNAseq | -3.2131 | 0.0000 | |
| SRP159526 | OCA2 | 4948 | RNAseq | -0.4070 | 0.6426 | |
| TCGA | OCA2 | 4948 | RNAseq | 0.8573 | 0.2230 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by OCA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OCA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OCA2 | 4948 | 3 | 7 | 20 | |
| GSE20123 | OCA2 | 4948 | 3 | 7 | 20 | |
| GSE43470 | OCA2 | 4948 | 4 | 5 | 34 | |
| GSE46452 | OCA2 | 4948 | 3 | 7 | 49 | |
| GSE47630 | OCA2 | 4948 | 8 | 11 | 21 | |
| GSE54993 | OCA2 | 4948 | 4 | 6 | 60 | |
| GSE54994 | OCA2 | 4948 | 7 | 6 | 40 | |
| GSE60625 | OCA2 | 4948 | 4 | 0 | 7 | |
| GSE74703 | OCA2 | 4948 | 4 | 3 | 29 | |
| GSE74704 | OCA2 | 4948 | 2 | 5 | 13 | |
| TCGA | OCA2 | 4948 | 16 | 17 | 63 |
Total number of gains: 58; Total number of losses: 74; Total Number of normals: 356.
Somatic mutations of OCA2:
Generating mutation plots.
Highly correlated genes for OCA2:
Showing top 20/719 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OCA2 | SAMD5 | 0.725909 | 6 | 0 | 6 |
| OCA2 | SH3BGRL2 | 0.708462 | 6 | 0 | 6 |
| OCA2 | SPNS2 | 0.701397 | 4 | 0 | 4 |
| OCA2 | TMPRSS11B | 0.699944 | 6 | 0 | 6 |
| OCA2 | ASPG | 0.696334 | 5 | 0 | 5 |
| OCA2 | SFTA2 | 0.689232 | 4 | 0 | 4 |
| OCA2 | SNORA68 | 0.686983 | 4 | 0 | 4 |
| OCA2 | KRT78 | 0.685488 | 6 | 0 | 6 |
| OCA2 | A2ML1 | 0.685409 | 6 | 0 | 6 |
| OCA2 | FAM3D | 0.684722 | 6 | 0 | 6 |
| OCA2 | VSIG10L | 0.68406 | 6 | 0 | 6 |
| OCA2 | PAQR8 | 0.677129 | 6 | 0 | 6 |
| OCA2 | PLAC9 | 0.673407 | 4 | 0 | 3 |
| OCA2 | CYSRT1 | 0.670058 | 6 | 0 | 6 |
| OCA2 | DMKN | 0.669489 | 3 | 0 | 3 |
| OCA2 | MAB21L3 | 0.668644 | 5 | 0 | 4 |
| OCA2 | SPAG17 | 0.667785 | 4 | 0 | 4 |
| OCA2 | PCBP1-AS1 | 0.667674 | 4 | 0 | 4 |
| OCA2 | FAM214A | 0.666267 | 6 | 0 | 5 |
| OCA2 | SLC46A2 | 0.663572 | 6 | 0 | 6 |
For details and further investigation, click here
