ORC5

 

Full name: origin recognition complex subunit 5 Alias Symbol: Orc5p|ORC5T|PPP1R117
Type: protein-coding gene Cytoband: 7q22.1-q22.2
Entrez ID: 5001 HGNC ID: HGNC:8491 Ensembl Gene: ENSG00000164815 OMIM ID: 602331
Drug and gene relationship at DGIdb
Screen Evidence:

 

ORC5 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of ORC5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ORC5 5001 204957_at 0.2646 0.6072
GSE20347 ORC5 5001 204957_at 0.5692 0.0193
GSE23400 ORC5 5001 204957_at 0.5039 0.0000
GSE26886 ORC5 5001 204957_at 0.3803 0.0200
GSE29001 ORC5 5001 204957_at 0.5457 0.0152
GSE38129 ORC5 5001 204957_at 0.6850 0.0001
GSE45670 ORC5 5001 204957_at 0.5515 0.0020
GSE53622 ORC5 5001 9890 0.6854 0.0000
GSE53624 ORC5 5001 127248 0.6657 0.0000
GSE63941 ORC5 5001 204957_at 0.4108 0.4399
GSE77861 ORC5 5001 204957_at 0.6049 0.0437
GSE97050 ORC5 5001 A_23_P31414 0.3085 0.2109
SRP007169 ORC5 5001 RNAseq 0.3479 0.3810
SRP008496 ORC5 5001 RNAseq 0.4448 0.1847
SRP064894 ORC5 5001 RNAseq 0.3124 0.0218
SRP133303 ORC5 5001 RNAseq 0.5664 0.0009
SRP159526 ORC5 5001 RNAseq 0.2010 0.4650
SRP193095 ORC5 5001 RNAseq 0.2746 0.0364
SRP219564 ORC5 5001 RNAseq 0.2325 0.4541

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ORC5 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of ORC5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ORC5 5001 13 0 17
GSE20123 ORC5 5001 13 0 17
GSE43470 ORC5 5001 6 1 36
GSE46452 ORC5 5001 10 1 48
GSE47630 ORC5 5001 7 3 30
GSE54993 ORC5 5001 1 11 58
GSE54994 ORC5 5001 16 3 34
GSE60625 ORC5 5001 0 0 11
GSE74703 ORC5 5001 6 1 29
GSE74704 ORC5 5001 9 0 11
TCGA ORC5 5001 54 6 36

Total number of gains: 135; Total number of losses: 26; Total Number of normals: 327.  

 

Somatic mutations of ORC5:

 

Generating mutation plots.

 

Highly correlated genes for ORC5:

 

Showing top 20/1694 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ORC5PTCD10.767385303
ORC5DUS4L0.75709312011
ORC5PSMC20.7490912012
ORC5ALG10.747608303
ORC5CENPBD10.746149404
ORC5CMTM40.745988303
ORC5ARMC100.737144808
ORC5SMARCAL10.735084303
ORC5NAIF10.730681303
ORC5ACBD50.725642303
ORC5ANAPC10.723777303
ORC5SESN30.721327303
ORC5BOLA30.711278505
ORC5FAM200A0.710608706
ORC5WDR360.709281404
ORC5AP1AR0.709168303
ORC5CDCA70.708473403
ORC5PUS70.70578812010
ORC5DNAJC20.70526612011
ORC5DGKH0.70295303

For details and further investigation, click here