PUS7

 

Full name: pseudouridine synthase 7 Alias Symbol: FLJ20485
Type: protein-coding gene Cytoband: 7q22.3
Entrez ID: 54517 HGNC ID: HGNC:26033 Ensembl Gene: ENSG00000091127 OMIM ID: 616261
Drug and gene relationship at DGIdb

 

Expression of PUS7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PUS7 54517 218984_at 0.9410 0.0777
GSE20347 PUS7 54517 218984_at 1.0819 0.0000
GSE23400 PUS7 54517 218984_at 1.1241 0.0000
GSE26886 PUS7 54517 218984_at 1.4843 0.0000
GSE29001 PUS7 54517 218984_at 1.0509 0.0003
GSE38129 PUS7 54517 218984_at 1.4250 0.0000
GSE45670 PUS7 54517 218984_at 0.7957 0.0008
GSE53622 PUS7 54517 29538 0.8150 0.0000
GSE53624 PUS7 54517 29538 0.9142 0.0000
GSE63941 PUS7 54517 218984_at 1.0373 0.0325
GSE77861 PUS7 54517 218984_at 1.1258 0.0006
GSE97050 PUS7 54517 A_23_P82478 0.5902 0.1760
SRP007169 PUS7 54517 RNAseq 0.8551 0.0180
SRP008496 PUS7 54517 RNAseq 0.9215 0.0005
SRP064894 PUS7 54517 RNAseq 0.7941 0.0105
SRP133303 PUS7 54517 RNAseq 0.8662 0.0000
SRP159526 PUS7 54517 RNAseq 0.5860 0.0498
SRP193095 PUS7 54517 RNAseq 0.8315 0.0000
SRP219564 PUS7 54517 RNAseq 0.8473 0.0819
TCGA PUS7 54517 RNAseq 0.5075 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by PUS7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PUS7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PUS7 54517 13 0 17
GSE20123 PUS7 54517 13 0 17
GSE43470 PUS7 54517 7 1 35
GSE46452 PUS7 54517 10 1 48
GSE47630 PUS7 54517 8 3 29
GSE54993 PUS7 54517 2 9 59
GSE54994 PUS7 54517 15 3 35
GSE60625 PUS7 54517 0 0 11
GSE74703 PUS7 54517 7 1 28
GSE74704 PUS7 54517 8 0 12
TCGA PUS7 54517 54 7 35

Total number of gains: 137; Total number of losses: 25; Total Number of normals: 326.  

 

Somatic mutations of PUS7:

 

Generating mutation plots.

 

Highly correlated genes for PUS7:

 

Showing top 20/1904 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PUS7DNAJC20.77771912012
PUS7CKS1B0.77169912012
PUS7UBE2T0.769325808
PUS7KNSTRN0.764879606
PUS7CENPF0.76067412012
PUS7TRIP130.75989612011
PUS7RAD510.75489110010
PUS7PRKDC0.75402210010
PUS7FANCI0.75313211011
PUS7AURKB0.75221612012
PUS7KIF140.75009512011
PUS7FBRSL10.746884403
PUS7KIF2C0.74490512011
PUS7POP70.74480713013
PUS7TIMELESS0.74458911011
PUS7GINS10.74357212011
PUS7DHX370.743487505
PUS7DUS4L0.73996911011
PUS7DMXL20.739849303
PUS7TNFAIP8L10.739668404

For details and further investigation, click here