| Full name: oxysterol binding protein | Alias Symbol: OSBP1 | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 5007 | HGNC ID: HGNC:8503 | Ensembl Gene: ENSG00000110048 | OMIM ID: 167040 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of OSBP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSBP | 5007 | 201800_s_at | -0.2847 | 0.3702 | |
| GSE20347 | OSBP | 5007 | 201800_s_at | 0.0317 | 0.8028 | |
| GSE23400 | OSBP | 5007 | 201800_s_at | 0.1382 | 0.0002 | |
| GSE26886 | OSBP | 5007 | 201800_s_at | -0.2502 | 0.1792 | |
| GSE29001 | OSBP | 5007 | 201800_s_at | -0.0912 | 0.7223 | |
| GSE38129 | OSBP | 5007 | 201800_s_at | -0.0367 | 0.7602 | |
| GSE45670 | OSBP | 5007 | 201800_s_at | -0.0594 | 0.6451 | |
| GSE53622 | OSBP | 5007 | 30838 | 0.0439 | 0.4932 | |
| GSE53624 | OSBP | 5007 | 18128 | 0.0598 | 0.4799 | |
| GSE63941 | OSBP | 5007 | 201800_s_at | 0.2489 | 0.5171 | |
| GSE77861 | OSBP | 5007 | 201800_s_at | 0.1820 | 0.2399 | |
| GSE97050 | OSBP | 5007 | A_23_P24709 | -0.0020 | 0.9925 | |
| SRP007169 | OSBP | 5007 | RNAseq | 1.0500 | 0.0043 | |
| SRP008496 | OSBP | 5007 | RNAseq | 0.8435 | 0.0014 | |
| SRP064894 | OSBP | 5007 | RNAseq | -0.2088 | 0.1645 | |
| SRP133303 | OSBP | 5007 | RNAseq | 0.0713 | 0.6561 | |
| SRP159526 | OSBP | 5007 | RNAseq | -0.1124 | 0.4751 | |
| SRP193095 | OSBP | 5007 | RNAseq | -0.0240 | 0.8325 | |
| SRP219564 | OSBP | 5007 | RNAseq | 0.3634 | 0.4258 | |
| TCGA | OSBP | 5007 | RNAseq | -0.1468 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by OSBP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSBP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSBP | 5007 | 1 | 5 | 24 | |
| GSE20123 | OSBP | 5007 | 1 | 5 | 24 | |
| GSE43470 | OSBP | 5007 | 2 | 5 | 36 | |
| GSE46452 | OSBP | 5007 | 9 | 4 | 46 | |
| GSE47630 | OSBP | 5007 | 3 | 8 | 29 | |
| GSE54993 | OSBP | 5007 | 3 | 0 | 67 | |
| GSE54994 | OSBP | 5007 | 5 | 6 | 42 | |
| GSE60625 | OSBP | 5007 | 0 | 3 | 8 | |
| GSE74703 | OSBP | 5007 | 2 | 3 | 31 | |
| GSE74704 | OSBP | 5007 | 1 | 4 | 15 | |
| TCGA | OSBP | 5007 | 12 | 11 | 73 |
Total number of gains: 39; Total number of losses: 54; Total Number of normals: 395.
Somatic mutations of OSBP:
Generating mutation plots.
Highly correlated genes for OSBP:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSBP | PSMD9 | 0.696878 | 4 | 0 | 4 |
| OSBP | CRADD | 0.67494 | 4 | 0 | 4 |
| OSBP | SNX7 | 0.669747 | 3 | 0 | 3 |
| OSBP | ST6GALNAC3 | 0.669566 | 3 | 0 | 3 |
| OSBP | L3MBTL3 | 0.668922 | 3 | 0 | 3 |
| OSBP | STX18 | 0.663246 | 3 | 0 | 3 |
| OSBP | DLD | 0.658532 | 4 | 0 | 3 |
| OSBP | CABYR | 0.641643 | 3 | 0 | 3 |
| OSBP | ABCG2 | 0.639868 | 4 | 0 | 3 |
| OSBP | ZW10 | 0.637845 | 5 | 0 | 4 |
| OSBP | NIT1 | 0.63455 | 3 | 0 | 3 |
| OSBP | TMEM107 | 0.632924 | 4 | 0 | 3 |
| OSBP | ATP6V0D1 | 0.62913 | 5 | 0 | 4 |
| OSBP | RHOJ | 0.626921 | 3 | 0 | 3 |
| OSBP | SNAPIN | 0.625885 | 4 | 0 | 4 |
| OSBP | ALAD | 0.620651 | 3 | 0 | 3 |
| OSBP | CUL5 | 0.620134 | 4 | 0 | 4 |
| OSBP | PLEKHM3 | 0.619279 | 3 | 0 | 3 |
| OSBP | MYCBP2 | 0.619053 | 3 | 0 | 3 |
| OSBP | APPBP2 | 0.611133 | 5 | 0 | 4 |
For details and further investigation, click here
