| Full name: zw10 kinetochore protein | Alias Symbol: KNTC1AP | ||
| Type: protein-coding gene | Cytoband: 11q23.2 | ||
| Entrez ID: 9183 | HGNC ID: HGNC:13194 | Ensembl Gene: ENSG00000086827 | OMIM ID: 603954 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ZW10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZW10 | 9183 | 204812_at | -0.1195 | 0.7501 | |
| GSE20347 | ZW10 | 9183 | 204812_at | -0.1279 | 0.2652 | |
| GSE23400 | ZW10 | 9183 | 204812_at | -0.0708 | 0.0687 | |
| GSE26886 | ZW10 | 9183 | 204812_at | -0.4986 | 0.1076 | |
| GSE29001 | ZW10 | 9183 | 204812_at | -0.2549 | 0.2757 | |
| GSE38129 | ZW10 | 9183 | 204812_at | -0.0175 | 0.8699 | |
| GSE45670 | ZW10 | 9183 | 204812_at | -0.0305 | 0.8764 | |
| GSE53622 | ZW10 | 9183 | 30817 | -0.0638 | 0.4595 | |
| GSE53624 | ZW10 | 9183 | 30817 | -0.0506 | 0.6380 | |
| GSE63941 | ZW10 | 9183 | 204812_at | 0.3976 | 0.3770 | |
| GSE77861 | ZW10 | 9183 | 204812_at | -0.0044 | 0.9887 | |
| GSE97050 | ZW10 | 9183 | A_23_P64204 | 0.3828 | 0.2747 | |
| SRP007169 | ZW10 | 9183 | RNAseq | -0.7238 | 0.0297 | |
| SRP008496 | ZW10 | 9183 | RNAseq | -0.3146 | 0.1110 | |
| SRP064894 | ZW10 | 9183 | RNAseq | -0.3627 | 0.0104 | |
| SRP133303 | ZW10 | 9183 | RNAseq | -0.0162 | 0.8992 | |
| SRP159526 | ZW10 | 9183 | RNAseq | -0.0479 | 0.9021 | |
| SRP193095 | ZW10 | 9183 | RNAseq | -0.4856 | 0.0000 | |
| SRP219564 | ZW10 | 9183 | RNAseq | -0.5884 | 0.0216 | |
| TCGA | ZW10 | 9183 | RNAseq | 0.0319 | 0.5661 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ZW10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZW10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZW10 | 9183 | 0 | 13 | 17 | |
| GSE20123 | ZW10 | 9183 | 0 | 13 | 17 | |
| GSE43470 | ZW10 | 9183 | 2 | 7 | 34 | |
| GSE46452 | ZW10 | 9183 | 3 | 26 | 30 | |
| GSE47630 | ZW10 | 9183 | 2 | 19 | 19 | |
| GSE54993 | ZW10 | 9183 | 10 | 0 | 60 | |
| GSE54994 | ZW10 | 9183 | 5 | 19 | 29 | |
| GSE60625 | ZW10 | 9183 | 0 | 3 | 8 | |
| GSE74703 | ZW10 | 9183 | 1 | 5 | 30 | |
| GSE74704 | ZW10 | 9183 | 0 | 9 | 11 | |
| TCGA | ZW10 | 9183 | 5 | 49 | 42 |
Total number of gains: 28; Total number of losses: 163; Total Number of normals: 297.
Somatic mutations of ZW10:
Generating mutation plots.
Highly correlated genes for ZW10:
Showing top 20/589 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZW10 | ELAC1 | 0.771501 | 3 | 0 | 3 |
| ZW10 | RALGPS2 | 0.759466 | 3 | 0 | 3 |
| ZW10 | C21orf91 | 0.751372 | 4 | 0 | 3 |
| ZW10 | GMCL1 | 0.731524 | 4 | 0 | 4 |
| ZW10 | CD163L1 | 0.725842 | 3 | 0 | 3 |
| ZW10 | BROX | 0.724069 | 3 | 0 | 3 |
| ZW10 | FAM3C | 0.717898 | 3 | 0 | 3 |
| ZW10 | SLC22A15 | 0.713331 | 3 | 0 | 3 |
| ZW10 | CD47 | 0.710503 | 3 | 0 | 3 |
| ZW10 | ARL6IP6 | 0.703104 | 3 | 0 | 3 |
| ZW10 | PRPF38A | 0.701824 | 3 | 0 | 3 |
| ZW10 | SURF4 | 0.700964 | 3 | 0 | 3 |
| ZW10 | SCO1 | 0.70028 | 4 | 0 | 4 |
| ZW10 | SRFBP1 | 0.698876 | 3 | 0 | 3 |
| ZW10 | ZNF543 | 0.693604 | 4 | 0 | 3 |
| ZW10 | SYPL1 | 0.689778 | 4 | 0 | 3 |
| ZW10 | SMARCAD1 | 0.688779 | 4 | 0 | 4 |
| ZW10 | VCPIP1 | 0.6877 | 3 | 0 | 3 |
| ZW10 | PATL1 | 0.686125 | 3 | 0 | 3 |
| ZW10 | SLBP | 0.68386 | 3 | 0 | 3 |
For details and further investigation, click here
