| Full name: amyloid beta precursor protein binding protein 2 | Alias Symbol: KIAA0228|Hs.84084|PAT1 | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 10513 | HGNC ID: HGNC:622 | Ensembl Gene: ENSG00000062725 | OMIM ID: 605324 |
| Drug and gene relationship at DGIdb | |||
Expression of APPBP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APPBP2 | 10513 | 202629_at | -0.4350 | 0.1824 | |
| GSE20347 | APPBP2 | 10513 | 202629_at | -0.4434 | 0.0010 | |
| GSE23400 | APPBP2 | 10513 | 202629_at | -0.1601 | 0.0003 | |
| GSE26886 | APPBP2 | 10513 | 202629_at | -0.9758 | 0.0035 | |
| GSE29001 | APPBP2 | 10513 | 202629_at | -0.4364 | 0.0195 | |
| GSE38129 | APPBP2 | 10513 | 202629_at | -0.3362 | 0.0006 | |
| GSE45670 | APPBP2 | 10513 | 202629_at | -0.2350 | 0.0606 | |
| GSE53622 | APPBP2 | 10513 | 110852 | -0.1897 | 0.0228 | |
| GSE53624 | APPBP2 | 10513 | 110852 | -0.3137 | 0.0016 | |
| GSE63941 | APPBP2 | 10513 | 202629_at | -0.8711 | 0.0205 | |
| GSE77861 | APPBP2 | 10513 | 202629_at | -0.1812 | 0.4875 | |
| GSE97050 | APPBP2 | 10513 | A_23_P207280 | -0.5382 | 0.1403 | |
| SRP007169 | APPBP2 | 10513 | RNAseq | -0.1637 | 0.6234 | |
| SRP008496 | APPBP2 | 10513 | RNAseq | -0.1979 | 0.1728 | |
| SRP064894 | APPBP2 | 10513 | RNAseq | -0.2352 | 0.1830 | |
| SRP133303 | APPBP2 | 10513 | RNAseq | 0.2022 | 0.1526 | |
| SRP159526 | APPBP2 | 10513 | RNAseq | -0.0660 | 0.6342 | |
| SRP193095 | APPBP2 | 10513 | RNAseq | -0.3777 | 0.0000 | |
| SRP219564 | APPBP2 | 10513 | RNAseq | -0.1224 | 0.5820 | |
| TCGA | APPBP2 | 10513 | RNAseq | -0.1111 | 0.0190 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by APPBP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APPBP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APPBP2 | 10513 | 5 | 1 | 24 | |
| GSE20123 | APPBP2 | 10513 | 5 | 1 | 24 | |
| GSE43470 | APPBP2 | 10513 | 5 | 0 | 38 | |
| GSE46452 | APPBP2 | 10513 | 32 | 0 | 27 | |
| GSE47630 | APPBP2 | 10513 | 7 | 1 | 32 | |
| GSE54993 | APPBP2 | 10513 | 2 | 5 | 63 | |
| GSE54994 | APPBP2 | 10513 | 9 | 5 | 39 | |
| GSE60625 | APPBP2 | 10513 | 4 | 0 | 7 | |
| GSE74703 | APPBP2 | 10513 | 5 | 0 | 31 | |
| GSE74704 | APPBP2 | 10513 | 4 | 1 | 15 | |
| TCGA | APPBP2 | 10513 | 29 | 6 | 61 |
Total number of gains: 107; Total number of losses: 20; Total Number of normals: 361.
Somatic mutations of APPBP2:
Generating mutation plots.
Highly correlated genes for APPBP2:
Showing top 20/1052 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APPBP2 | FAM174A | 0.778879 | 3 | 0 | 3 |
| APPBP2 | ZDHHC21 | 0.76573 | 4 | 0 | 4 |
| APPBP2 | OCM2 | 0.759841 | 3 | 0 | 3 |
| APPBP2 | MKRN1 | 0.748001 | 3 | 0 | 3 |
| APPBP2 | KDM3A | 0.747817 | 3 | 0 | 3 |
| APPBP2 | CPEB4 | 0.732218 | 4 | 0 | 3 |
| APPBP2 | MAP4K3 | 0.731401 | 3 | 0 | 3 |
| APPBP2 | AHRR | 0.728509 | 3 | 0 | 3 |
| APPBP2 | IMPACT | 0.725368 | 4 | 0 | 3 |
| APPBP2 | SYTL4 | 0.723654 | 3 | 0 | 3 |
| APPBP2 | ZFC3H1 | 0.723275 | 4 | 0 | 4 |
| APPBP2 | BRK1 | 0.721513 | 4 | 0 | 3 |
| APPBP2 | CBLL1 | 0.72101 | 4 | 0 | 3 |
| APPBP2 | UBE4B | 0.71899 | 5 | 0 | 5 |
| APPBP2 | FGD4 | 0.716029 | 5 | 0 | 5 |
| APPBP2 | SHROOM3 | 0.715612 | 3 | 0 | 3 |
| APPBP2 | C19orf18 | 0.713525 | 3 | 0 | 3 |
| APPBP2 | SCAI | 0.708672 | 3 | 0 | 3 |
| APPBP2 | AP3S2 | 0.7086 | 3 | 0 | 3 |
| APPBP2 | PDCD7 | 0.708384 | 3 | 0 | 3 |
For details and further investigation, click here
