| Full name: purinergic receptor P2X 3 | Alias Symbol: P2X3 | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 5024 | HGNC ID: HGNC:8534 | Ensembl Gene: ENSG00000109991 | OMIM ID: 600843 |
| Drug and gene relationship at DGIdb | |||
P2RX3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04742 | Taste transduction |
Expression of P2RX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RX3 | 5024 | 208338_at | 0.0022 | 0.9941 | |
| GSE20347 | P2RX3 | 5024 | 208338_at | -0.0638 | 0.2796 | |
| GSE23400 | P2RX3 | 5024 | 208338_at | -0.0814 | 0.0025 | |
| GSE26886 | P2RX3 | 5024 | 208338_at | 0.0721 | 0.4702 | |
| GSE29001 | P2RX3 | 5024 | 208338_at | -0.1180 | 0.2990 | |
| GSE38129 | P2RX3 | 5024 | 208338_at | -0.0957 | 0.0546 | |
| GSE45670 | P2RX3 | 5024 | 208338_at | 0.0611 | 0.4027 | |
| GSE53622 | P2RX3 | 5024 | 16185 | -1.4051 | 0.0000 | |
| GSE53624 | P2RX3 | 5024 | 16185 | -2.1976 | 0.0000 | |
| GSE63941 | P2RX3 | 5024 | 208338_at | 0.0892 | 0.5919 | |
| GSE77861 | P2RX3 | 5024 | 208338_at | -0.1162 | 0.3110 | |
| GSE97050 | P2RX3 | 5024 | A_23_P127721 | 0.0254 | 0.9414 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by P2RX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RX3 | 5024 | 2 | 3 | 25 | |
| GSE20123 | P2RX3 | 5024 | 2 | 3 | 25 | |
| GSE43470 | P2RX3 | 5024 | 1 | 5 | 37 | |
| GSE46452 | P2RX3 | 5024 | 9 | 4 | 46 | |
| GSE47630 | P2RX3 | 5024 | 3 | 9 | 28 | |
| GSE54993 | P2RX3 | 5024 | 3 | 0 | 67 | |
| GSE54994 | P2RX3 | 5024 | 5 | 6 | 42 | |
| GSE60625 | P2RX3 | 5024 | 0 | 3 | 8 | |
| GSE74703 | P2RX3 | 5024 | 1 | 3 | 32 | |
| GSE74704 | P2RX3 | 5024 | 2 | 3 | 15 | |
| TCGA | P2RX3 | 5024 | 14 | 10 | 72 |
Total number of gains: 42; Total number of losses: 49; Total Number of normals: 397.
Somatic mutations of P2RX3:
Generating mutation plots.
Highly correlated genes for P2RX3:
Showing top 20/753 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RX3 | SPRR2F | 0.839222 | 3 | 0 | 3 |
| P2RX3 | SPRR2E | 0.826997 | 3 | 0 | 3 |
| P2RX3 | SPRR2D | 0.815928 | 3 | 0 | 3 |
| P2RX3 | SPRR2A | 0.812672 | 3 | 0 | 3 |
| P2RX3 | RNF222 | 0.784409 | 3 | 0 | 3 |
| P2RX3 | TMPRSS11A | 0.76712 | 3 | 0 | 3 |
| P2RX3 | SPRR2B | 0.76671 | 3 | 0 | 3 |
| P2RX3 | S100A9 | 0.763624 | 3 | 0 | 3 |
| P2RX3 | NCCRP1 | 0.760755 | 3 | 0 | 3 |
| P2RX3 | ACOT12 | 0.729275 | 3 | 0 | 3 |
| P2RX3 | SPATA19 | 0.725831 | 3 | 0 | 3 |
| P2RX3 | ZNF460 | 0.7195 | 3 | 0 | 3 |
| P2RX3 | RUNX1T1 | 0.717536 | 3 | 0 | 3 |
| P2RX3 | FAM163B | 0.714774 | 3 | 0 | 3 |
| P2RX3 | RAET1E | 0.713534 | 3 | 0 | 3 |
| P2RX3 | TEAD3 | 0.711883 | 3 | 0 | 3 |
| P2RX3 | KPRP | 0.709908 | 3 | 0 | 3 |
| P2RX3 | SDR9C7 | 0.707623 | 3 | 0 | 3 |
| P2RX3 | NTNG1 | 0.705947 | 4 | 0 | 4 |
| P2RX3 | NAPA | 0.701085 | 3 | 0 | 3 |
For details and further investigation, click here
