| Full name: small proline rich protein 2B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6701 | HGNC ID: HGNC:11262 | Ensembl Gene: ENSG00000196805 | OMIM ID: 182268 |
| Drug and gene relationship at DGIdb | |||
Expression of SPRR2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | SPRR2B | 6701 | 62703 | -1.8416 | 0.0000 | |
| GSE53624 | SPRR2B | 6701 | 62703 | -2.7556 | 0.0000 | |
| GSE97050 | SPRR2B | 6701 | A_33_P3247431 | -0.2225 | 0.3973 | |
| SRP007169 | SPRR2B | 6701 | RNAseq | -6.1723 | 0.0007 | |
| SRP064894 | SPRR2B | 6701 | RNAseq | -2.6400 | 0.0027 | |
| SRP133303 | SPRR2B | 6701 | RNAseq | -1.9244 | 0.0460 | |
| SRP159526 | SPRR2B | 6701 | RNAseq | -3.1794 | 0.0881 | |
| TCGA | SPRR2B | 6701 | RNAseq | 1.5656 | 0.0230 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by SPRR2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRR2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRR2B | 6701 | 15 | 0 | 15 | |
| GSE20123 | SPRR2B | 6701 | 15 | 0 | 15 | |
| GSE43470 | SPRR2B | 6701 | 6 | 2 | 35 | |
| GSE46452 | SPRR2B | 6701 | 3 | 1 | 55 | |
| GSE47630 | SPRR2B | 6701 | 15 | 0 | 25 | |
| GSE54993 | SPRR2B | 6701 | 0 | 4 | 66 | |
| GSE54994 | SPRR2B | 6701 | 16 | 0 | 37 | |
| GSE60625 | SPRR2B | 6701 | 0 | 0 | 11 | |
| GSE74703 | SPRR2B | 6701 | 6 | 1 | 29 | |
| GSE74704 | SPRR2B | 6701 | 7 | 0 | 13 | |
| TCGA | SPRR2B | 6701 | 39 | 2 | 55 |
Total number of gains: 122; Total number of losses: 10; Total Number of normals: 356.
Somatic mutations of SPRR2B:
Generating mutation plots.
Highly correlated genes for SPRR2B:
Showing top 20/337 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRR2B | SPRR2E | 0.883592 | 4 | 0 | 4 |
| SPRR2B | SPRR2D | 0.8745 | 4 | 0 | 4 |
| SPRR2B | GPR45 | 0.865281 | 3 | 0 | 3 |
| SPRR2B | SPRR2F | 0.852931 | 4 | 0 | 4 |
| SPRR2B | PGLYRP3 | 0.835317 | 3 | 0 | 3 |
| SPRR2B | SPRR2A | 0.809252 | 4 | 0 | 4 |
| SPRR2B | TGM1 | 0.807314 | 4 | 0 | 4 |
| SPRR2B | ATG9B | 0.803508 | 3 | 0 | 3 |
| SPRR2B | CNFN | 0.802054 | 4 | 0 | 4 |
| SPRR2B | C19orf57 | 0.791766 | 3 | 0 | 3 |
| SPRR2B | CTNNBIP1 | 0.790474 | 3 | 0 | 3 |
| SPRR2B | TMPRSS11E | 0.789609 | 3 | 0 | 3 |
| SPRR2B | IL36A | 0.785741 | 3 | 0 | 3 |
| SPRR2B | SPRR1B | 0.785603 | 4 | 0 | 4 |
| SPRR2B | PRAMEF10 | 0.777057 | 3 | 0 | 3 |
| SPRR2B | SBSN | 0.772874 | 4 | 0 | 4 |
| SPRR2B | KLK12 | 0.772828 | 4 | 0 | 4 |
| SPRR2B | CEACAM6 | 0.769671 | 3 | 0 | 3 |
| SPRR2B | ATP13A4 | 0.768548 | 3 | 0 | 3 |
| SPRR2B | P2RX3 | 0.76671 | 3 | 0 | 3 |
For details and further investigation, click here
