| Full name: N-myc downstream regulated 1 | Alias Symbol: DRG1|RTP|TDD5|NDR1 | ||
| Type: protein-coding gene | Cytoband: 8q24.22 | ||
| Entrez ID: 10397 | HGNC ID: HGNC:7679 | Ensembl Gene: ENSG00000104419 | OMIM ID: 605262 |
| Drug and gene relationship at DGIdb | |||
Expression of NDRG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NDRG1 | 10397 | 200632_s_at | 0.2921 | 0.8153 | |
| GSE20347 | NDRG1 | 10397 | 200632_s_at | 0.5300 | 0.0744 | |
| GSE23400 | NDRG1 | 10397 | 200632_s_at | 0.7182 | 0.0000 | |
| GSE26886 | NDRG1 | 10397 | 200632_s_at | 0.0836 | 0.7710 | |
| GSE29001 | NDRG1 | 10397 | 200632_s_at | 0.1116 | 0.8492 | |
| GSE38129 | NDRG1 | 10397 | 200632_s_at | 0.7491 | 0.0035 | |
| GSE45670 | NDRG1 | 10397 | 200632_s_at | 0.7941 | 0.0035 | |
| GSE53622 | NDRG1 | 10397 | 96002 | 0.8026 | 0.0000 | |
| GSE53624 | NDRG1 | 10397 | 96002 | 0.8825 | 0.0000 | |
| GSE63941 | NDRG1 | 10397 | 200632_s_at | -0.8099 | 0.5316 | |
| GSE77861 | NDRG1 | 10397 | 200632_s_at | 0.4620 | 0.3244 | |
| GSE97050 | NDRG1 | 10397 | A_23_P20494 | 1.2001 | 0.0599 | |
| SRP007169 | NDRG1 | 10397 | RNAseq | -0.2797 | 0.5554 | |
| SRP008496 | NDRG1 | 10397 | RNAseq | -0.0618 | 0.8768 | |
| SRP064894 | NDRG1 | 10397 | RNAseq | 0.6343 | 0.0868 | |
| SRP133303 | NDRG1 | 10397 | RNAseq | 1.2613 | 0.0005 | |
| SRP159526 | NDRG1 | 10397 | RNAseq | -0.4846 | 0.3673 | |
| SRP193095 | NDRG1 | 10397 | RNAseq | 1.2984 | 0.0000 | |
| SRP219564 | NDRG1 | 10397 | RNAseq | -0.1335 | 0.8403 | |
| TCGA | NDRG1 | 10397 | RNAseq | 0.3035 | 0.0018 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NDRG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NDRG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NDRG1 | 10397 | 16 | 0 | 14 | |
| GSE20123 | NDRG1 | 10397 | 17 | 0 | 13 | |
| GSE43470 | NDRG1 | 10397 | 23 | 1 | 19 | |
| GSE46452 | NDRG1 | 10397 | 27 | 0 | 32 | |
| GSE47630 | NDRG1 | 10397 | 24 | 0 | 16 | |
| GSE54993 | NDRG1 | 10397 | 0 | 24 | 46 | |
| GSE54994 | NDRG1 | 10397 | 39 | 1 | 13 | |
| GSE60625 | NDRG1 | 10397 | 0 | 7 | 4 | |
| GSE74703 | NDRG1 | 10397 | 20 | 0 | 16 | |
| GSE74704 | NDRG1 | 10397 | 12 | 0 | 8 | |
| TCGA | NDRG1 | 10397 | 66 | 2 | 28 |
Total number of gains: 244; Total number of losses: 35; Total Number of normals: 209.
Somatic mutations of NDRG1:
Generating mutation plots.
Highly correlated genes for NDRG1:
Showing top 20/334 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NDRG1 | SLC2A1 | 0.701906 | 12 | 0 | 12 |
| NDRG1 | KRT17 | 0.668135 | 4 | 0 | 4 |
| NDRG1 | PABPN1 | 0.659214 | 3 | 0 | 3 |
| NDRG1 | KRT16 | 0.649575 | 10 | 0 | 9 |
| NDRG1 | LDHA | 0.648808 | 12 | 0 | 10 |
| NDRG1 | C4orf47 | 0.640986 | 4 | 0 | 3 |
| NDRG1 | KISS1R | 0.635733 | 4 | 0 | 3 |
| NDRG1 | PDIA3 | 0.620943 | 4 | 0 | 3 |
| NDRG1 | BNC1 | 0.619085 | 11 | 0 | 9 |
| NDRG1 | NSMAF | 0.617593 | 3 | 0 | 3 |
| NDRG1 | PFKFB4 | 0.616179 | 7 | 0 | 6 |
| NDRG1 | IGSF6 | 0.616066 | 3 | 0 | 3 |
| NDRG1 | CMIP | 0.611895 | 5 | 0 | 4 |
| NDRG1 | PPP6R1 | 0.610468 | 3 | 0 | 3 |
| NDRG1 | TMEM167A | 0.610302 | 3 | 0 | 3 |
| NDRG1 | ISM1 | 0.609596 | 4 | 0 | 3 |
| NDRG1 | HK2 | 0.608135 | 12 | 0 | 10 |
| NDRG1 | KRT14 | 0.606783 | 11 | 0 | 9 |
| NDRG1 | ADAM8 | 0.605314 | 3 | 0 | 3 |
| NDRG1 | RCC2 | 0.605075 | 4 | 0 | 4 |
For details and further investigation, click here
