| Full name: CLN8 transmembrane ER and ERGIC protein | Alias Symbol: FLJ39417|TLCD6 | ||
| Type: protein-coding gene | Cytoband: 8p23.3 | ||
| Entrez ID: 2055 | HGNC ID: HGNC:2079 | Ensembl Gene: ENSG00000182372 | OMIM ID: 607837 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CLN8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLN8 | 2055 | 223912_s_at | 0.1182 | 0.8270 | |
| GSE20347 | CLN8 | 2055 | 219340_s_at | -0.3918 | 0.0006 | |
| GSE23400 | CLN8 | 2055 | 219340_s_at | -0.1124 | 0.0002 | |
| GSE26886 | CLN8 | 2055 | 223912_s_at | -1.3604 | 0.0000 | |
| GSE29001 | CLN8 | 2055 | 219340_s_at | -0.5973 | 0.0086 | |
| GSE38129 | CLN8 | 2055 | 219340_s_at | -0.2200 | 0.0655 | |
| GSE45670 | CLN8 | 2055 | 229958_at | -0.3610 | 0.1397 | |
| GSE53622 | CLN8 | 2055 | 42029 | -1.2559 | 0.0000 | |
| GSE53624 | CLN8 | 2055 | 42029 | -1.4328 | 0.0000 | |
| GSE63941 | CLN8 | 2055 | 229958_at | -0.2304 | 0.7835 | |
| GSE77861 | CLN8 | 2055 | 223912_s_at | 0.1261 | 0.5975 | |
| GSE97050 | CLN8 | 2055 | A_23_P407206 | -0.0332 | 0.9231 | |
| SRP007169 | CLN8 | 2055 | RNAseq | -1.7935 | 0.0000 | |
| SRP008496 | CLN8 | 2055 | RNAseq | -1.5107 | 0.0000 | |
| SRP064894 | CLN8 | 2055 | RNAseq | -0.5759 | 0.0026 | |
| SRP133303 | CLN8 | 2055 | RNAseq | -0.7621 | 0.0000 | |
| SRP159526 | CLN8 | 2055 | RNAseq | -0.5576 | 0.0231 | |
| SRP193095 | CLN8 | 2055 | RNAseq | -0.7329 | 0.0000 | |
| SRP219564 | CLN8 | 2055 | RNAseq | -0.5384 | 0.1799 | |
| TCGA | CLN8 | 2055 | RNAseq | -0.4229 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by CLN8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLN8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLN8 | 2055 | 5 | 13 | 12 | |
| GSE20123 | CLN8 | 2055 | 5 | 13 | 12 | |
| GSE43470 | CLN8 | 2055 | 5 | 9 | 29 | |
| GSE46452 | CLN8 | 2055 | 12 | 14 | 33 | |
| GSE47630 | CLN8 | 2055 | 10 | 8 | 22 | |
| GSE54993 | CLN8 | 2055 | 4 | 14 | 52 | |
| GSE54994 | CLN8 | 2055 | 10 | 18 | 25 | |
| GSE60625 | CLN8 | 2055 | 3 | 0 | 8 | |
| GSE74703 | CLN8 | 2055 | 5 | 7 | 24 | |
| GSE74704 | CLN8 | 2055 | 4 | 8 | 8 | |
| TCGA | CLN8 | 2055 | 14 | 41 | 41 |
Total number of gains: 77; Total number of losses: 145; Total Number of normals: 266.
Somatic mutations of CLN8:
Generating mutation plots.
Highly correlated genes for CLN8:
Showing top 20/549 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLN8 | TBRG1 | 0.778841 | 3 | 0 | 3 |
| CLN8 | USP45 | 0.756564 | 4 | 0 | 4 |
| CLN8 | OPHN1 | 0.752433 | 3 | 0 | 3 |
| CLN8 | RAB10 | 0.736223 | 3 | 0 | 3 |
| CLN8 | NUFIP2 | 0.72874 | 4 | 0 | 4 |
| CLN8 | ULK3 | 0.715927 | 4 | 0 | 4 |
| CLN8 | LMAN1 | 0.699753 | 3 | 0 | 3 |
| CLN8 | HMGN3 | 0.69786 | 4 | 0 | 3 |
| CLN8 | MTHFR | 0.696008 | 3 | 0 | 3 |
| CLN8 | DDX52 | 0.69371 | 3 | 0 | 3 |
| CLN8 | CMTM4 | 0.692173 | 3 | 0 | 3 |
| CLN8 | OSBPL10 | 0.690942 | 7 | 0 | 7 |
| CLN8 | ZNF662 | 0.689823 | 4 | 0 | 4 |
| CLN8 | MPZL3 | 0.688784 | 4 | 0 | 4 |
| CLN8 | CYSRT1 | 0.688744 | 3 | 0 | 3 |
| CLN8 | SULT2B1 | 0.686795 | 5 | 0 | 5 |
| CLN8 | BTBD7 | 0.684847 | 4 | 0 | 4 |
| CLN8 | TRIM33 | 0.683677 | 3 | 0 | 3 |
| CLN8 | MTIF3 | 0.681197 | 3 | 0 | 3 |
| CLN8 | BOK | 0.67907 | 3 | 0 | 3 |
For details and further investigation, click here
