| Full name: AF4/FMR2 family member 4 | Alias Symbol: AF5Q31|MCEF | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 27125 | HGNC ID: HGNC:17869 | Ensembl Gene: ENSG00000072364 | OMIM ID: 604417 |
| Drug and gene relationship at DGIdb | |||
Expression of AFF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AFF4 | 27125 | 225229_at | -0.7080 | 0.1100 | |
| GSE20347 | AFF4 | 27125 | 219199_at | -0.5123 | 0.0010 | |
| GSE23400 | AFF4 | 27125 | 219199_at | -0.5029 | 0.0000 | |
| GSE26886 | AFF4 | 27125 | 225229_at | -0.7799 | 0.0022 | |
| GSE29001 | AFF4 | 27125 | 219199_at | -0.7058 | 0.0026 | |
| GSE38129 | AFF4 | 27125 | 219199_at | -0.4986 | 0.0021 | |
| GSE45670 | AFF4 | 27125 | 225229_at | -0.3531 | 0.0175 | |
| GSE53622 | AFF4 | 27125 | 161825 | -0.7966 | 0.0000 | |
| GSE53624 | AFF4 | 27125 | 161825 | -0.7469 | 0.0000 | |
| GSE63941 | AFF4 | 27125 | 225229_at | -1.0500 | 0.0150 | |
| GSE77861 | AFF4 | 27125 | 225229_at | -0.7863 | 0.0586 | |
| GSE97050 | AFF4 | 27125 | A_24_P8318 | -0.4299 | 0.1453 | |
| SRP007169 | AFF4 | 27125 | RNAseq | -1.3251 | 0.0001 | |
| SRP008496 | AFF4 | 27125 | RNAseq | -1.2764 | 0.0000 | |
| SRP064894 | AFF4 | 27125 | RNAseq | -1.0591 | 0.0002 | |
| SRP133303 | AFF4 | 27125 | RNAseq | -0.1992 | 0.2707 | |
| SRP159526 | AFF4 | 27125 | RNAseq | -1.0238 | 0.0058 | |
| SRP193095 | AFF4 | 27125 | RNAseq | -0.9289 | 0.0000 | |
| SRP219564 | AFF4 | 27125 | RNAseq | -0.8083 | 0.0762 | |
| TCGA | AFF4 | 27125 | RNAseq | -0.2205 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by AFF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AFF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AFF4 | 27125 | 1 | 11 | 18 | |
| GSE20123 | AFF4 | 27125 | 2 | 11 | 17 | |
| GSE43470 | AFF4 | 27125 | 2 | 9 | 32 | |
| GSE46452 | AFF4 | 27125 | 0 | 27 | 32 | |
| GSE47630 | AFF4 | 27125 | 0 | 21 | 19 | |
| GSE54993 | AFF4 | 27125 | 9 | 1 | 60 | |
| GSE54994 | AFF4 | 27125 | 2 | 16 | 35 | |
| GSE60625 | AFF4 | 27125 | 0 | 0 | 11 | |
| GSE74703 | AFF4 | 27125 | 2 | 6 | 28 | |
| GSE74704 | AFF4 | 27125 | 1 | 5 | 14 | |
| TCGA | AFF4 | 27125 | 3 | 39 | 54 |
Total number of gains: 22; Total number of losses: 146; Total Number of normals: 320.
Somatic mutations of AFF4:
Generating mutation plots.
Highly correlated genes for AFF4:
Showing top 20/1222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AFF4 | MXD1 | 0.763044 | 10 | 0 | 10 |
| AFF4 | ALKBH7 | 0.7508 | 3 | 0 | 3 |
| AFF4 | VSIG10L | 0.735562 | 6 | 0 | 6 |
| AFF4 | MRPS36 | 0.723476 | 7 | 0 | 7 |
| AFF4 | ATG12 | 0.719751 | 4 | 0 | 4 |
| AFF4 | CTNNA1 | 0.719704 | 12 | 0 | 11 |
| AFF4 | SKP1 | 0.717921 | 8 | 0 | 8 |
| AFF4 | LRRFIP2 | 0.713526 | 12 | 0 | 12 |
| AFF4 | FAM174A | 0.710124 | 9 | 0 | 8 |
| AFF4 | CDKN2AIP | 0.704687 | 11 | 0 | 11 |
| AFF4 | CYSRT1 | 0.703934 | 6 | 0 | 6 |
| AFF4 | ZMAT2 | 0.703571 | 5 | 0 | 5 |
| AFF4 | A2ML1 | 0.701722 | 6 | 0 | 6 |
| AFF4 | CRCT1 | 0.696819 | 10 | 0 | 10 |
| AFF4 | C18orf25 | 0.696018 | 12 | 0 | 11 |
| AFF4 | PITHD1 | 0.695442 | 5 | 0 | 5 |
| AFF4 | RMND5B | 0.695335 | 11 | 0 | 11 |
| AFF4 | SPINK7 | 0.695316 | 6 | 0 | 6 |
| AFF4 | VSIG2 | 0.694396 | 5 | 0 | 5 |
| AFF4 | FCHO2 | 0.69264 | 9 | 0 | 7 |
For details and further investigation, click here
