PAK1

 

Full name: p21 (RAC1) activated kinase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 11q13.5-q14.1
Entrez ID: 5058 HGNC ID: HGNC:8590 Ensembl Gene: ENSG00000149269 OMIM ID: 602590
Drug and gene relationship at DGIdb
Screen Evidence:

 

PAK1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04810Regulation of actin cytoskeleton
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma

 

Expression of PAK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PAK1 5058 226507_at 0.1721 0.7709
GSE20347 PAK1 5058 209615_s_at 0.8897 0.0028
GSE23400 PAK1 5058 209615_s_at 0.4469 0.0000
GSE26886 PAK1 5058 226507_at 0.7759 0.0004
GSE29001 PAK1 5058 209615_s_at 0.4612 0.1851
GSE38129 PAK1 5058 209615_s_at 1.1824 0.0000
GSE45670 PAK1 5058 226507_at 0.3853 0.2577
GSE53622 PAK1 5058 140166 0.6421 0.0000
GSE53624 PAK1 5058 140166 0.8623 0.0000
GSE63941 PAK1 5058 226507_at 0.5847 0.2856
GSE77861 PAK1 5058 226507_at 0.6219 0.0804
GSE97050 PAK1 5058 A_33_P3784253 0.0165 0.9698
SRP007169 PAK1 5058 RNAseq 2.0151 0.0007
SRP008496 PAK1 5058 RNAseq 0.8847 0.0001
SRP064894 PAK1 5058 RNAseq 0.7710 0.0001
SRP133303 PAK1 5058 RNAseq 0.3131 0.1330
SRP159526 PAK1 5058 RNAseq 1.0277 0.0675
SRP193095 PAK1 5058 RNAseq -0.0359 0.8529
SRP219564 PAK1 5058 RNAseq 0.8208 0.1070
TCGA PAK1 5058 RNAseq 0.0008 0.9915

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by PAK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PAK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PAK1 5058 5 9 16
GSE20123 PAK1 5058 5 8 17
GSE43470 PAK1 5058 3 3 37
GSE46452 PAK1 5058 8 21 30
GSE47630 PAK1 5058 4 17 19
GSE54993 PAK1 5058 8 2 60
GSE54994 PAK1 5058 6 17 30
GSE60625 PAK1 5058 4 3 4
GSE74703 PAK1 5058 2 2 32
GSE74704 PAK1 5058 3 4 13
TCGA PAK1 5058 20 31 45

Total number of gains: 68; Total number of losses: 117; Total Number of normals: 303.  

 

Somatic mutations of PAK1:

 

Generating mutation plots.

 

Highly correlated genes for PAK1:

 

Showing top 20/1021 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PAK1ZCCHC30.838897303
PAK1UBR10.820918303
PAK1CWF19L20.807281303
PAK1DPYSL20.792667303
PAK1ANKS60.787613303
PAK1RNF260.78266303
PAK1RBM410.775036303
PAK1TMTC10.76655404
PAK1RILPL20.761321303
PAK1TMEM600.753279303
PAK1ARPP190.741904303
PAK1STON10.740855303
PAK1SNTB20.739696303
PAK1SGTB0.739644303
PAK1BMPR20.739586303
PAK1FAF20.736819303
PAK1BRAP0.729728303
PAK1PHIP0.726067505
PAK1MRPS50.715772303
PAK1SFT2D30.710221504

For details and further investigation, click here