TBK1

 

Full name: TANK binding kinase 1 Alias Symbol: NAK
Type: protein-coding gene Cytoband: 12q14.2
Entrez ID: 29110 HGNC ID: HGNC:11584 Ensembl Gene: ENSG00000183735 OMIM ID: 604834
Drug and gene relationship at DGIdb
Screen Evidence:

 

TBK1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection

 

Expression of TBK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TBK1 29110 218520_at 0.0039 0.9916
GSE20347 TBK1 29110 218520_at 0.2813 0.0034
GSE23400 TBK1 29110 218520_at 0.3507 0.0000
GSE26886 TBK1 29110 218520_at -0.7255 0.0010
GSE29001 TBK1 29110 218520_at 0.3614 0.1452
GSE38129 TBK1 29110 218520_at 0.3323 0.0007
GSE45670 TBK1 29110 218520_at -0.0028 0.9851
GSE53622 TBK1 29110 7544 0.2387 0.0000
GSE53624 TBK1 29110 7544 0.1725 0.0007
GSE63941 TBK1 29110 218520_at -0.5103 0.2806
GSE77861 TBK1 29110 218520_at 0.3491 0.0647
GSE97050 TBK1 29110 A_23_P44768 0.2123 0.4765
SRP007169 TBK1 29110 RNAseq 0.1115 0.7561
SRP008496 TBK1 29110 RNAseq 0.2313 0.2891
SRP064894 TBK1 29110 RNAseq 0.1384 0.5508
SRP133303 TBK1 29110 RNAseq 0.7997 0.0009
SRP159526 TBK1 29110 RNAseq 0.0682 0.8207
SRP193095 TBK1 29110 RNAseq 0.1879 0.1797
SRP219564 TBK1 29110 RNAseq 0.4314 0.3797
TCGA TBK1 29110 RNAseq 0.1046 0.0722

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TBK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TBK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TBK1 29110 5 1 24
GSE20123 TBK1 29110 5 1 24
GSE43470 TBK1 29110 5 0 38
GSE46452 TBK1 29110 11 0 48
GSE47630 TBK1 29110 10 2 28
GSE54993 TBK1 29110 0 6 64
GSE54994 TBK1 29110 8 1 44
GSE60625 TBK1 29110 0 0 11
GSE74703 TBK1 29110 5 0 31
GSE74704 TBK1 29110 4 1 15
TCGA TBK1 29110 19 10 67

Total number of gains: 72; Total number of losses: 22; Total Number of normals: 394.  

 

Somatic mutations of TBK1:

 

Generating mutation plots.

 

Highly correlated genes for TBK1:

 

Showing top 20/658 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TBK1PANK10.798674303
TBK1ERCC60.781621303
TBK1NUFIP20.769835303
TBK1SLTM0.767307303
TBK1GTF2IRD10.765153303
TBK1RPRD1B0.763155303
TBK1C3orf380.762742303
TBK1DUSP160.747721303
TBK1HEATR5B0.745516404
TBK1TUBGCP40.734123303
TBK1ZNF920.727541303
TBK1ZNF518B0.724591303
TBK1BROX0.72161303
TBK1DUS3L0.721252303
TBK1OSBPL80.719216505
TBK1ETV60.716055303
TBK1POLDIP30.71305303
TBK1THAP20.707856303
TBK1ALG20.702075403
TBK1ACTR30.696251303

For details and further investigation, click here