| Full name: dual specificity phosphatase 16 | Alias Symbol: MKP-7|KIAA1700|MKP7 | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 80824 | HGNC ID: HGNC:17909 | Ensembl Gene: ENSG00000111266 | OMIM ID: 607175 |
| Drug and gene relationship at DGIdb | |||
DUSP16 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of DUSP16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUSP16 | 80824 | 224832_at | 0.0509 | 0.9568 | |
| GSE26886 | DUSP16 | 80824 | 224832_at | -0.8972 | 0.0081 | |
| GSE45670 | DUSP16 | 80824 | 224832_at | 0.0409 | 0.8347 | |
| GSE53622 | DUSP16 | 80824 | 87916 | 0.2579 | 0.0457 | |
| GSE53624 | DUSP16 | 80824 | 100841 | -0.6204 | 0.0000 | |
| GSE63941 | DUSP16 | 80824 | 224832_at | 0.6567 | 0.1281 | |
| GSE77861 | DUSP16 | 80824 | 224832_at | -0.0304 | 0.9153 | |
| GSE97050 | DUSP16 | 80824 | A_24_P189739 | 0.0529 | 0.9352 | |
| SRP007169 | DUSP16 | 80824 | RNAseq | -1.6134 | 0.0000 | |
| SRP008496 | DUSP16 | 80824 | RNAseq | -1.4939 | 0.0000 | |
| SRP064894 | DUSP16 | 80824 | RNAseq | -1.3227 | 0.0000 | |
| SRP133303 | DUSP16 | 80824 | RNAseq | -0.3787 | 0.0123 | |
| SRP159526 | DUSP16 | 80824 | RNAseq | -0.9473 | 0.0000 | |
| SRP193095 | DUSP16 | 80824 | RNAseq | -0.5762 | 0.0000 | |
| SRP219564 | DUSP16 | 80824 | RNAseq | -0.7958 | 0.0780 | |
| TCGA | DUSP16 | 80824 | RNAseq | -0.2012 | 0.0057 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by DUSP16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUSP16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUSP16 | 80824 | 6 | 2 | 22 | |
| GSE20123 | DUSP16 | 80824 | 6 | 2 | 22 | |
| GSE43470 | DUSP16 | 80824 | 10 | 4 | 29 | |
| GSE46452 | DUSP16 | 80824 | 10 | 1 | 48 | |
| GSE47630 | DUSP16 | 80824 | 13 | 2 | 25 | |
| GSE54993 | DUSP16 | 80824 | 2 | 9 | 59 | |
| GSE54994 | DUSP16 | 80824 | 10 | 2 | 41 | |
| GSE60625 | DUSP16 | 80824 | 0 | 1 | 10 | |
| GSE74703 | DUSP16 | 80824 | 9 | 3 | 24 | |
| GSE74704 | DUSP16 | 80824 | 4 | 1 | 15 | |
| TCGA | DUSP16 | 80824 | 39 | 7 | 50 |
Total number of gains: 109; Total number of losses: 34; Total Number of normals: 345.
Somatic mutations of DUSP16:
Generating mutation plots.
Highly correlated genes for DUSP16:
Showing top 20/190 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUSP16 | CASP3 | 0.816998 | 3 | 0 | 3 |
| DUSP16 | TMEM218 | 0.794008 | 3 | 0 | 3 |
| DUSP16 | RBM8A | 0.771766 | 3 | 0 | 3 |
| DUSP16 | NCOA2 | 0.767858 | 3 | 0 | 3 |
| DUSP16 | PLEKHG1 | 0.756274 | 3 | 0 | 3 |
| DUSP16 | AP3M1 | 0.751597 | 3 | 0 | 3 |
| DUSP16 | TBK1 | 0.747721 | 3 | 0 | 3 |
| DUSP16 | COPS7A | 0.743305 | 4 | 0 | 4 |
| DUSP16 | PEX11B | 0.729585 | 3 | 0 | 3 |
| DUSP16 | FBXO3 | 0.726028 | 3 | 0 | 3 |
| DUSP16 | PBRM1 | 0.724014 | 3 | 0 | 3 |
| DUSP16 | LRMP | 0.723336 | 4 | 0 | 3 |
| DUSP16 | NPAT | 0.718599 | 3 | 0 | 3 |
| DUSP16 | PAN2 | 0.718376 | 3 | 0 | 3 |
| DUSP16 | CPEB4 | 0.709845 | 3 | 0 | 3 |
| DUSP16 | CUL3 | 0.704955 | 3 | 0 | 3 |
| DUSP16 | SLTM | 0.703237 | 3 | 0 | 3 |
| DUSP16 | AP1B1 | 0.701963 | 3 | 0 | 3 |
| DUSP16 | SETX | 0.701045 | 3 | 0 | 3 |
| DUSP16 | ZCCHC8 | 0.700469 | 3 | 0 | 3 |
For details and further investigation, click here
