| Full name: PBX homeobox 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 5087 | HGNC ID: HGNC:8632 | Ensembl Gene: ENSG00000185630 | OMIM ID: 176310 |
| Drug and gene relationship at DGIdb | |||
Expression of PBX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PBX1 | 5087 | 212151_at | -0.8095 | 0.3040 | |
| GSE20347 | PBX1 | 5087 | 212151_at | -0.9643 | 0.0007 | |
| GSE23400 | PBX1 | 5087 | 212151_at | -0.6563 | 0.0000 | |
| GSE26886 | PBX1 | 5087 | 212151_at | -1.3766 | 0.0041 | |
| GSE29001 | PBX1 | 5087 | 212151_at | -0.5666 | 0.2234 | |
| GSE38129 | PBX1 | 5087 | 212151_at | -1.1383 | 0.0003 | |
| GSE45670 | PBX1 | 5087 | 212151_at | -1.4295 | 0.0002 | |
| GSE53622 | PBX1 | 5087 | 96193 | -1.4038 | 0.0000 | |
| GSE53624 | PBX1 | 5087 | 96193 | -1.1319 | 0.0000 | |
| GSE63941 | PBX1 | 5087 | 212151_at | -1.7517 | 0.0224 | |
| GSE77861 | PBX1 | 5087 | 212151_at | -0.3520 | 0.2339 | |
| GSE97050 | PBX1 | 5087 | A_23_P62953 | -1.5223 | 0.0820 | |
| SRP007169 | PBX1 | 5087 | RNAseq | -1.3816 | 0.0051 | |
| SRP008496 | PBX1 | 5087 | RNAseq | -0.8755 | 0.0025 | |
| SRP064894 | PBX1 | 5087 | RNAseq | -1.0117 | 0.0018 | |
| SRP133303 | PBX1 | 5087 | RNAseq | -0.7991 | 0.0015 | |
| SRP159526 | PBX1 | 5087 | RNAseq | -0.3643 | 0.2644 | |
| SRP193095 | PBX1 | 5087 | RNAseq | -0.7391 | 0.0000 | |
| SRP219564 | PBX1 | 5087 | RNAseq | -0.6503 | 0.4262 | |
| TCGA | PBX1 | 5087 | RNAseq | -0.3856 | 0.0065 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by PBX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PBX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PBX1 | 5087 | 10 | 1 | 19 | |
| GSE20123 | PBX1 | 5087 | 10 | 1 | 19 | |
| GSE43470 | PBX1 | 5087 | 7 | 2 | 34 | |
| GSE46452 | PBX1 | 5087 | 2 | 1 | 56 | |
| GSE47630 | PBX1 | 5087 | 14 | 0 | 26 | |
| GSE54993 | PBX1 | 5087 | 0 | 5 | 65 | |
| GSE54994 | PBX1 | 5087 | 16 | 0 | 37 | |
| GSE60625 | PBX1 | 5087 | 0 | 0 | 11 | |
| GSE74703 | PBX1 | 5087 | 7 | 2 | 27 | |
| GSE74704 | PBX1 | 5087 | 4 | 1 | 15 | |
| TCGA | PBX1 | 5087 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 17; Total Number of normals: 358.
Somatic mutations of PBX1:
Generating mutation plots.
Highly correlated genes for PBX1:
Showing top 20/1258 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PBX1 | BAG3 | 0.752252 | 3 | 0 | 3 |
| PBX1 | ANO5 | 0.744 | 5 | 0 | 5 |
| PBX1 | C1QTNF7 | 0.735151 | 5 | 0 | 5 |
| PBX1 | AFF3 | 0.734757 | 3 | 0 | 3 |
| PBX1 | PGM5 | 0.730971 | 7 | 0 | 7 |
| PBX1 | DDX42 | 0.730015 | 3 | 0 | 3 |
| PBX1 | CYP21A2 | 0.729175 | 3 | 0 | 3 |
| PBX1 | LIMS2 | 0.728996 | 7 | 0 | 6 |
| PBX1 | OGN | 0.722497 | 7 | 0 | 7 |
| PBX1 | SORCS1 | 0.721962 | 4 | 0 | 4 |
| PBX1 | RNF150 | 0.719114 | 6 | 0 | 5 |
| PBX1 | SPOP | 0.718422 | 7 | 0 | 7 |
| PBX1 | FOXP2 | 0.718272 | 5 | 0 | 4 |
| PBX1 | PWAR5 | 0.717658 | 3 | 0 | 3 |
| PBX1 | ARHGEF25 | 0.71751 | 4 | 0 | 4 |
| PBX1 | DISP1 | 0.715106 | 4 | 0 | 4 |
| PBX1 | CASQ2 | 0.713317 | 8 | 0 | 7 |
| PBX1 | AQP1 | 0.711108 | 11 | 0 | 11 |
| PBX1 | MTFR1L | 0.709766 | 5 | 0 | 5 |
| PBX1 | FAM200B | 0.709386 | 4 | 0 | 3 |
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