| Full name: PBX homeobox 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q33.3 | ||
| Entrez ID: 5090 | HGNC ID: HGNC:8634 | Ensembl Gene: ENSG00000167081 | OMIM ID: 176312 |
| Drug and gene relationship at DGIdb | |||
Expression of PBX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PBX3 | 5090 | 204082_at | -0.6899 | 0.0758 | |
| GSE20347 | PBX3 | 5090 | 204082_at | -0.7781 | 0.0000 | |
| GSE23400 | PBX3 | 5090 | 204082_at | -0.1795 | 0.1222 | |
| GSE26886 | PBX3 | 5090 | 204082_at | -0.3452 | 0.1578 | |
| GSE29001 | PBX3 | 5090 | 204082_at | -0.1476 | 0.6800 | |
| GSE38129 | PBX3 | 5090 | 204082_at | -0.7406 | 0.0002 | |
| GSE45670 | PBX3 | 5090 | 204082_at | -1.0973 | 0.0000 | |
| GSE53622 | PBX3 | 5090 | 76485 | -0.3260 | 0.0007 | |
| GSE53624 | PBX3 | 5090 | 114768 | -0.2264 | 0.0361 | |
| GSE63941 | PBX3 | 5090 | 204082_at | -2.0249 | 0.0037 | |
| GSE77861 | PBX3 | 5090 | 204082_at | -0.4494 | 0.3120 | |
| GSE97050 | PBX3 | 5090 | A_23_P71821 | -0.3367 | 0.2515 | |
| SRP007169 | PBX3 | 5090 | RNAseq | 0.7574 | 0.0636 | |
| SRP008496 | PBX3 | 5090 | RNAseq | 1.3000 | 0.0012 | |
| SRP064894 | PBX3 | 5090 | RNAseq | 0.2012 | 0.3493 | |
| SRP133303 | PBX3 | 5090 | RNAseq | 0.2313 | 0.4486 | |
| SRP159526 | PBX3 | 5090 | RNAseq | -0.4603 | 0.0794 | |
| SRP193095 | PBX3 | 5090 | RNAseq | -0.4246 | 0.0035 | |
| SRP219564 | PBX3 | 5090 | RNAseq | -0.4342 | 0.5007 | |
| TCGA | PBX3 | 5090 | RNAseq | -0.1789 | 0.0204 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by PBX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PBX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PBX3 | 5090 | 4 | 8 | 18 | |
| GSE20123 | PBX3 | 5090 | 4 | 8 | 18 | |
| GSE43470 | PBX3 | 5090 | 5 | 6 | 32 | |
| GSE46452 | PBX3 | 5090 | 6 | 13 | 40 | |
| GSE47630 | PBX3 | 5090 | 3 | 16 | 21 | |
| GSE54993 | PBX3 | 5090 | 3 | 3 | 64 | |
| GSE54994 | PBX3 | 5090 | 12 | 9 | 32 | |
| GSE60625 | PBX3 | 5090 | 0 | 0 | 11 | |
| GSE74703 | PBX3 | 5090 | 5 | 4 | 27 | |
| GSE74704 | PBX3 | 5090 | 2 | 6 | 12 | |
| TCGA | PBX3 | 5090 | 27 | 25 | 44 |
Total number of gains: 71; Total number of losses: 98; Total Number of normals: 319.
Somatic mutations of PBX3:
Generating mutation plots.
Highly correlated genes for PBX3:
Showing top 20/892 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PBX3 | STARD9 | 0.809311 | 5 | 0 | 5 |
| PBX3 | ABCA9 | 0.740925 | 3 | 0 | 3 |
| PBX3 | LRRN4CL | 0.736052 | 5 | 0 | 5 |
| PBX3 | AKAP6 | 0.719108 | 3 | 0 | 3 |
| PBX3 | NLGN4Y | 0.714845 | 3 | 0 | 3 |
| PBX3 | GFRA1 | 0.71392 | 5 | 0 | 4 |
| PBX3 | RASSF3 | 0.711316 | 4 | 0 | 4 |
| PBX3 | PPP1R14A | 0.708245 | 4 | 0 | 4 |
| PBX3 | RUNX1T1 | 0.707758 | 6 | 0 | 5 |
| PBX3 | INMT | 0.707739 | 5 | 0 | 5 |
| PBX3 | CNTN3 | 0.704857 | 3 | 0 | 3 |
| PBX3 | SGCA | 0.704693 | 6 | 0 | 6 |
| PBX3 | XKR4 | 0.700958 | 4 | 0 | 4 |
| PBX3 | C11orf96 | 0.700783 | 4 | 0 | 3 |
| PBX3 | BNC2 | 0.698909 | 8 | 0 | 8 |
| PBX3 | FIBIN | 0.697498 | 5 | 0 | 4 |
| PBX3 | COX7A1 | 0.696287 | 8 | 0 | 7 |
| PBX3 | RNF150 | 0.695927 | 5 | 0 | 5 |
| PBX3 | LIMS2 | 0.695646 | 7 | 0 | 7 |
| PBX3 | ITGA7 | 0.694357 | 6 | 0 | 6 |
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