Full name: IST1 factor associated with ESCRT-III	Alias Symbol: CHMP8
Type: protein-coding gene	Cytoband: 16q22.2
Entrez ID: 9798	HGNC ID: HGNC:28977	Ensembl Gene: ENSG00000182149	OMIM ID: 616434
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 38/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of IST1:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	IST1	9798	200851_s_at	0.1039	0.7858	Show
GSE20347	IST1	9798	200851_s_at	0.1803	0.0250	Show
GSE23400	IST1	9798	200851_s_at	0.0811	0.1135	Show
GSE26886	IST1	9798	200851_s_at	-0.5097	0.0005	Show
GSE29001	IST1	9798	200851_s_at	-0.0435	0.7697	Show
GSE38129	IST1	9798	200851_s_at	0.1902	0.0304	Show
GSE45670	IST1	9798	200851_s_at	0.0224	0.8042	Show
GSE53622	IST1	9798	95770	0.0174	0.7865	Show
GSE53624	IST1	9798	100603	-0.0212	0.6825	Show
GSE63941	IST1	9798	200851_s_at	0.1952	0.5789	Show
GSE77861	IST1	9798	200851_s_at	0.2530	0.1609	Show
GSE97050	IST1	9798	A_23_P206759	0.0316	0.9317	Show
SRP007169	IST1	9798	RNAseq	-0.8727	0.0080	Show
SRP008496	IST1	9798	RNAseq	-0.7826	0.0018	Show
SRP064894	IST1	9798	RNAseq	-0.3094	0.0041	Show
SRP133303	IST1	9798	RNAseq	0.0879	0.4785	Show
SRP159526	IST1	9798	RNAseq	-0.0438	0.8237	Show
SRP193095	IST1	9798	RNAseq	-0.1934	0.0409	Show
SRP219564	IST1	9798	RNAseq	-0.3186	0.2039	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by IST1 expression:

 

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Copy number change of IST1:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	IST1	9798	4	0	26	Show
GSE20123	IST1	9798	4	0	26	Show
GSE43470	IST1	9798	2	8	33	Show
GSE46452	IST1	9798	38	2	19	Show
GSE47630	IST1	9798	11	8	21	Show
GSE54993	IST1	9798	2	4	64	Show
GSE54994	IST1	9798	8	10	35	Show
GSE60625	IST1	9798	4	0	7	Show
GSE74703	IST1	9798	2	5	29	Show
GSE74704	IST1	9798	2	0	18	Show
TCGA	IST1	9798	27	13	56	Show

Total number of gains: 104; Total number of losses: 50; Total Number of normals: 334.  Download Data

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Somatic mutations of IST1:

 

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Highly correlated genes for IST1:

 

Showing top 20/206 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
IST1	SNX12	0.794351	3	0	3
IST1	COX7A2L	0.766371	3	0	3
IST1	PPIE	0.7584	3	0	3
IST1	RAB21	0.750489	3	0	3
IST1	LRBA	0.737528	3	0	3
IST1	SUPT4H1	0.734411	4	0	4
IST1	ZNF595	0.732001	3	0	3
IST1	NAA20	0.720175	3	0	3
IST1	GCLC	0.719371	3	0	3
IST1	WARS2	0.716398	3	0	3
IST1	BSDC1	0.713125	3	0	3
IST1	MRPL37	0.709668	3	0	3
IST1	SPAG9	0.707114	3	0	3
IST1	SLC7A6	0.698988	3	0	3
IST1	ATP6V1B2	0.691018	4	0	3
IST1	TNIP1	0.689935	3	0	3
IST1	RAB1A	0.688579	4	0	3
IST1	EML4	0.686465	4	0	3
IST1	TTLL4	0.686108	3	0	3
IST1	PCDH12	0.686091	3	0	3

For details and further investigation, click here