| Full name: THO complex 5 | Alias Symbol: PK1.3|KIAA0983|Fmip|fSAP79 | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 8563 | HGNC ID: HGNC:19074 | Ensembl Gene: ENSG00000100296 | OMIM ID: 612733 |
| Drug and gene relationship at DGIdb | |||
Expression of THOC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THOC5 | 8563 | 209418_s_at | 0.3605 | 0.3337 | |
| GSE20347 | THOC5 | 8563 | 209418_s_at | 0.4410 | 0.0032 | |
| GSE23400 | THOC5 | 8563 | 209418_s_at | 0.3987 | 0.0000 | |
| GSE26886 | THOC5 | 8563 | 209418_s_at | 0.7756 | 0.0002 | |
| GSE29001 | THOC5 | 8563 | 209418_s_at | 0.4934 | 0.0680 | |
| GSE38129 | THOC5 | 8563 | 209418_s_at | 0.4227 | 0.0001 | |
| GSE45670 | THOC5 | 8563 | 209418_s_at | 0.3538 | 0.1165 | |
| GSE53622 | THOC5 | 8563 | 10723 | 0.7761 | 0.0000 | |
| GSE53624 | THOC5 | 8563 | 10723 | 0.8993 | 0.0000 | |
| GSE63941 | THOC5 | 8563 | 209418_s_at | 0.4087 | 0.2677 | |
| GSE77861 | THOC5 | 8563 | 209418_s_at | 0.4964 | 0.0307 | |
| GSE97050 | THOC5 | 8563 | A_23_P109470 | 0.3212 | 0.2492 | |
| SRP007169 | THOC5 | 8563 | RNAseq | 1.0841 | 0.0045 | |
| SRP008496 | THOC5 | 8563 | RNAseq | 1.1281 | 0.0010 | |
| SRP064894 | THOC5 | 8563 | RNAseq | 0.8531 | 0.0000 | |
| SRP133303 | THOC5 | 8563 | RNAseq | 0.3826 | 0.0125 | |
| SRP159526 | THOC5 | 8563 | RNAseq | 0.8756 | 0.0008 | |
| SRP193095 | THOC5 | 8563 | RNAseq | 0.6503 | 0.0000 | |
| SRP219564 | THOC5 | 8563 | RNAseq | 0.3648 | 0.4295 | |
| TCGA | THOC5 | 8563 | RNAseq | 0.0655 | 0.2200 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by THOC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THOC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THOC5 | 8563 | 3 | 5 | 22 | |
| GSE20123 | THOC5 | 8563 | 3 | 4 | 23 | |
| GSE43470 | THOC5 | 8563 | 4 | 5 | 34 | |
| GSE46452 | THOC5 | 8563 | 31 | 1 | 27 | |
| GSE47630 | THOC5 | 8563 | 8 | 5 | 27 | |
| GSE54993 | THOC5 | 8563 | 3 | 6 | 61 | |
| GSE54994 | THOC5 | 8563 | 11 | 8 | 34 | |
| GSE60625 | THOC5 | 8563 | 5 | 0 | 6 | |
| GSE74703 | THOC5 | 8563 | 4 | 4 | 28 | |
| GSE74704 | THOC5 | 8563 | 0 | 1 | 19 | |
| TCGA | THOC5 | 8563 | 27 | 16 | 53 |
Total number of gains: 99; Total number of losses: 55; Total Number of normals: 334.
Somatic mutations of THOC5:
Generating mutation plots.
Highly correlated genes for THOC5:
Showing top 20/1835 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THOC5 | USE1 | 0.792363 | 3 | 0 | 3 |
| THOC5 | SLC35B2 | 0.788214 | 3 | 0 | 3 |
| THOC5 | SCNM1 | 0.78711 | 3 | 0 | 3 |
| THOC5 | NF1 | 0.76328 | 3 | 0 | 3 |
| THOC5 | PLEKHB2 | 0.762916 | 3 | 0 | 3 |
| THOC5 | RAB34 | 0.760664 | 3 | 0 | 3 |
| THOC5 | NEIL2 | 0.756065 | 3 | 0 | 3 |
| THOC5 | PYCR2 | 0.756037 | 3 | 0 | 3 |
| THOC5 | SGCE | 0.754684 | 3 | 0 | 3 |
| THOC5 | DHX40 | 0.75398 | 3 | 0 | 3 |
| THOC5 | ADSL | 0.747907 | 13 | 0 | 12 |
| THOC5 | B4GALT4 | 0.737538 | 3 | 0 | 3 |
| THOC5 | ZNF628 | 0.733676 | 3 | 0 | 3 |
| THOC5 | FADS1 | 0.730556 | 3 | 0 | 3 |
| THOC5 | DRG1 | 0.728701 | 11 | 0 | 11 |
| THOC5 | PMS2 | 0.72709 | 3 | 0 | 3 |
| THOC5 | WDR54 | 0.726007 | 8 | 0 | 7 |
| THOC5 | ANAPC1 | 0.725703 | 3 | 0 | 3 |
| THOC5 | PLEKHG2 | 0.724382 | 3 | 0 | 3 |
| THOC5 | DOCK11 | 0.720785 | 3 | 0 | 3 |
For details and further investigation, click here
