| Full name: HOP homeobox | Alias Symbol: LAGY|HOP|OB1|NECC1|SMAP31 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 84525 | HGNC ID: HGNC:24961 | Ensembl Gene: ENSG00000171476 | OMIM ID: 607275 |
| Drug and gene relationship at DGIdb | |||
Expression of HOPX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOPX | 84525 | 211597_s_at | -2.2225 | 0.1787 | |
| GSE20347 | HOPX | 84525 | 211597_s_at | -3.7112 | 0.0000 | |
| GSE23400 | HOPX | 84525 | 211597_s_at | -2.8524 | 0.0000 | |
| GSE26886 | HOPX | 84525 | 211597_s_at | -3.8172 | 0.0000 | |
| GSE29001 | HOPX | 84525 | 211597_s_at | -3.4418 | 0.0000 | |
| GSE38129 | HOPX | 84525 | 211597_s_at | -2.3172 | 0.0001 | |
| GSE45670 | HOPX | 84525 | 211597_s_at | -1.1085 | 0.0119 | |
| GSE53622 | HOPX | 84525 | 119506 | -2.9060 | 0.0000 | |
| GSE53624 | HOPX | 84525 | 119506 | -3.3106 | 0.0000 | |
| GSE63941 | HOPX | 84525 | 211597_s_at | -0.2155 | 0.9166 | |
| GSE77861 | HOPX | 84525 | 211597_s_at | -2.6546 | 0.0161 | |
| GSE97050 | HOPX | 84525 | A_23_P254507 | -1.1746 | 0.3820 | |
| SRP007169 | HOPX | 84525 | RNAseq | -6.9025 | 0.0000 | |
| SRP008496 | HOPX | 84525 | RNAseq | -5.9796 | 0.0000 | |
| SRP064894 | HOPX | 84525 | RNAseq | -4.2830 | 0.0000 | |
| SRP133303 | HOPX | 84525 | RNAseq | -3.7959 | 0.0000 | |
| SRP159526 | HOPX | 84525 | RNAseq | -4.1437 | 0.0000 | |
| SRP193095 | HOPX | 84525 | RNAseq | -4.5420 | 0.0000 | |
| SRP219564 | HOPX | 84525 | RNAseq | -4.1944 | 0.0000 | |
| TCGA | HOPX | 84525 | RNAseq | -0.0362 | 0.8207 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by HOPX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOPX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOPX | 84525 | 3 | 12 | 15 | |
| GSE20123 | HOPX | 84525 | 2 | 12 | 16 | |
| GSE43470 | HOPX | 84525 | 0 | 14 | 29 | |
| GSE46452 | HOPX | 84525 | 1 | 36 | 22 | |
| GSE47630 | HOPX | 84525 | 0 | 19 | 21 | |
| GSE54993 | HOPX | 84525 | 7 | 0 | 63 | |
| GSE54994 | HOPX | 84525 | 2 | 10 | 41 | |
| GSE60625 | HOPX | 84525 | 0 | 0 | 11 | |
| GSE74703 | HOPX | 84525 | 0 | 12 | 24 | |
| GSE74704 | HOPX | 84525 | 1 | 7 | 12 | |
| TCGA | HOPX | 84525 | 21 | 26 | 49 |
Total number of gains: 37; Total number of losses: 148; Total Number of normals: 303.
Somatic mutations of HOPX:
Generating mutation plots.
Highly correlated genes for HOPX:
Showing top 20/1811 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOPX | ENDOU | 0.878895 | 11 | 0 | 11 |
| HOPX | CLIC3 | 0.875975 | 10 | 0 | 10 |
| HOPX | CLCA4 | 0.859731 | 12 | 0 | 12 |
| HOPX | SPINK5 | 0.858855 | 12 | 0 | 12 |
| HOPX | PPL | 0.852741 | 12 | 0 | 12 |
| HOPX | CRNN | 0.852684 | 12 | 0 | 12 |
| HOPX | CRISP3 | 0.849955 | 12 | 0 | 12 |
| HOPX | TMPRSS11B | 0.849546 | 8 | 0 | 8 |
| HOPX | CSTB | 0.849334 | 12 | 0 | 12 |
| HOPX | SCEL | 0.847846 | 13 | 0 | 12 |
| HOPX | KLK13 | 0.847821 | 12 | 0 | 12 |
| HOPX | ZNF185 | 0.847778 | 12 | 0 | 12 |
| HOPX | ECM1 | 0.846817 | 12 | 0 | 11 |
| HOPX | EMP1 | 0.846782 | 12 | 0 | 12 |
| HOPX | EPS8L1 | 0.84653 | 12 | 0 | 11 |
| HOPX | GYS2 | 0.846325 | 10 | 0 | 10 |
| HOPX | PRSS3 | 0.846247 | 12 | 0 | 11 |
| HOPX | C1orf116 | 0.846178 | 12 | 0 | 12 |
| HOPX | UPK3B | 0.845801 | 3 | 0 | 3 |
| HOPX | RANBP9 | 0.842474 | 11 | 0 | 11 |
For details and further investigation, click here
