| Full name: phosducin | Alias Symbol: MEKA | ||
| Type: protein-coding gene | Cytoband: 1q31.1 | ||
| Entrez ID: 5132 | HGNC ID: HGNC:8759 | Ensembl Gene: ENSG00000116703 | OMIM ID: 171490 |
| Drug and gene relationship at DGIdb | |||
Expression of PDC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDC | 5132 | 211496_s_at | -0.0298 | 0.9144 | |
| GSE20347 | PDC | 5132 | 211496_s_at | -0.0300 | 0.5767 | |
| GSE23400 | PDC | 5132 | 211496_s_at | -0.0932 | 0.0018 | |
| GSE26886 | PDC | 5132 | 211496_s_at | -0.0010 | 0.9918 | |
| GSE29001 | PDC | 5132 | 211496_s_at | -0.1915 | 0.1268 | |
| GSE38129 | PDC | 5132 | 211496_s_at | -0.0856 | 0.0529 | |
| GSE45670 | PDC | 5132 | 211496_s_at | 0.0871 | 0.2578 | |
| GSE53622 | PDC | 5132 | 175302 | -0.2457 | 0.0073 | |
| GSE53624 | PDC | 5132 | 175302 | -0.7538 | 0.0000 | |
| GSE63941 | PDC | 5132 | 211496_s_at | 0.0034 | 0.9826 | |
| GSE77861 | PDC | 5132 | 211496_s_at | -0.0576 | 0.5798 | |
| GSE97050 | PDC | 5132 | A_23_P23090 | -0.1554 | 0.4755 | |
| TCGA | PDC | 5132 | RNAseq | -0.2597 | 0.6308 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDC | 5132 | 10 | 0 | 20 | |
| GSE20123 | PDC | 5132 | 10 | 0 | 20 | |
| GSE43470 | PDC | 5132 | 6 | 1 | 36 | |
| GSE46452 | PDC | 5132 | 3 | 1 | 55 | |
| GSE47630 | PDC | 5132 | 14 | 0 | 26 | |
| GSE54993 | PDC | 5132 | 0 | 6 | 64 | |
| GSE54994 | PDC | 5132 | 15 | 0 | 38 | |
| GSE60625 | PDC | 5132 | 0 | 0 | 11 | |
| GSE74703 | PDC | 5132 | 6 | 1 | 29 | |
| GSE74704 | PDC | 5132 | 4 | 0 | 16 | |
| TCGA | PDC | 5132 | 40 | 4 | 52 |
Total number of gains: 108; Total number of losses: 13; Total Number of normals: 367.
Somatic mutations of PDC:
Generating mutation plots.
Highly correlated genes for PDC:
Showing top 20/306 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDC | GDF10 | 0.701618 | 3 | 0 | 3 |
| PDC | G6PC2 | 0.69398 | 4 | 0 | 4 |
| PDC | SLC6A5 | 0.69044 | 3 | 0 | 3 |
| PDC | MYOG | 0.687298 | 3 | 0 | 3 |
| PDC | RHAG | 0.680744 | 3 | 0 | 3 |
| PDC | TNFRSF13B | 0.6781 | 3 | 0 | 3 |
| PDC | CRHR2 | 0.674125 | 4 | 0 | 3 |
| PDC | STXBP6 | 0.669082 | 3 | 0 | 3 |
| PDC | IL1RAPL1 | 0.656554 | 3 | 0 | 3 |
| PDC | CPNE6 | 0.652534 | 3 | 0 | 3 |
| PDC | MYL3 | 0.650563 | 3 | 0 | 3 |
| PDC | DEFA6 | 0.649362 | 4 | 0 | 4 |
| PDC | LGALS14 | 0.647188 | 3 | 0 | 3 |
| PDC | SHCBP1L | 0.647107 | 4 | 0 | 4 |
| PDC | HAO2 | 0.646769 | 3 | 0 | 3 |
| PDC | CBLN1 | 0.642113 | 3 | 0 | 3 |
| PDC | SERPINA6 | 0.635832 | 4 | 0 | 4 |
| PDC | TRPC7 | 0.635217 | 4 | 0 | 4 |
| PDC | NOX5 | 0.633115 | 3 | 0 | 3 |
| PDC | PDE6A | 0.631948 | 3 | 0 | 3 |
For details and further investigation, click here
