| Full name: T cell leukemia/lymphoma 1B | Alias Symbol: TML1 | ||
| Type: protein-coding gene | Cytoband: 14q32.13 | ||
| Entrez ID: 9623 | HGNC ID: HGNC:11649 | Ensembl Gene: ENSG00000213231 | OMIM ID: 603769 |
| Drug and gene relationship at DGIdb | |||
TCL1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway |
Expression of TCL1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCL1B | 9623 | 206413_s_at | -0.1159 | 0.6440 | |
| GSE20347 | TCL1B | 9623 | 206413_s_at | -0.0340 | 0.7598 | |
| GSE23400 | TCL1B | 9623 | 206413_s_at | -0.1184 | 0.0004 | |
| GSE26886 | TCL1B | 9623 | 206413_s_at | 0.0922 | 0.3258 | |
| GSE29001 | TCL1B | 9623 | 206413_s_at | -0.0471 | 0.8467 | |
| GSE38129 | TCL1B | 9623 | 206413_s_at | -0.1309 | 0.0660 | |
| GSE45670 | TCL1B | 9623 | 206413_s_at | 0.0115 | 0.9162 | |
| GSE63941 | TCL1B | 9623 | 206413_s_at | 0.0099 | 0.9636 | |
| GSE77861 | TCL1B | 9623 | 206413_s_at | -0.1172 | 0.3222 | |
| GSE97050 | TCL1B | 9623 | A_23_P48495 | 0.0329 | 0.8969 | |
| TCGA | TCL1B | 9623 | RNAseq | 1.5354 | 0.2757 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TCL1B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TCL1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCL1B | 9623 | 10 | 4 | 16 | |
| GSE20123 | TCL1B | 9623 | 10 | 3 | 17 | |
| GSE43470 | TCL1B | 9623 | 8 | 3 | 32 | |
| GSE46452 | TCL1B | 9623 | 16 | 3 | 40 | |
| GSE47630 | TCL1B | 9623 | 11 | 8 | 21 | |
| GSE54993 | TCL1B | 9623 | 3 | 8 | 59 | |
| GSE54994 | TCL1B | 9623 | 21 | 4 | 28 | |
| GSE60625 | TCL1B | 9623 | 0 | 2 | 9 | |
| GSE74703 | TCL1B | 9623 | 6 | 3 | 27 | |
| GSE74704 | TCL1B | 9623 | 6 | 3 | 11 | |
| TCGA | TCL1B | 9623 | 30 | 19 | 47 |
Total number of gains: 121; Total number of losses: 60; Total Number of normals: 307.
Somatic mutations of TCL1B:
Generating mutation plots.
Highly correlated genes for TCL1B:
Showing top 20/896 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCL1B | CNTNAP1 | 0.790635 | 3 | 0 | 3 |
| TCL1B | CLCN7 | 0.769813 | 3 | 0 | 3 |
| TCL1B | CD36 | 0.752165 | 3 | 0 | 3 |
| TCL1B | FZD4 | 0.735017 | 4 | 0 | 4 |
| TCL1B | CBL | 0.731765 | 5 | 0 | 5 |
| TCL1B | TCTN1 | 0.725862 | 3 | 0 | 3 |
| TCL1B | PTPRJ | 0.713173 | 5 | 0 | 5 |
| TCL1B | MAP4 | 0.711483 | 3 | 0 | 3 |
| TCL1B | MTAP | 0.709722 | 6 | 0 | 6 |
| TCL1B | RAPGEF1 | 0.703893 | 4 | 0 | 4 |
| TCL1B | C9orf50 | 0.703221 | 3 | 0 | 3 |
| TCL1B | MAPK11 | 0.699209 | 5 | 0 | 4 |
| TCL1B | ADPRH | 0.696965 | 4 | 0 | 4 |
| TCL1B | SCNN1G | 0.696533 | 4 | 0 | 4 |
| TCL1B | ZNF747 | 0.694791 | 4 | 0 | 4 |
| TCL1B | TCTN2 | 0.692174 | 4 | 0 | 4 |
| TCL1B | PDE3B | 0.687686 | 5 | 0 | 5 |
| TCL1B | C1orf68 | 0.685894 | 5 | 0 | 4 |
| TCL1B | DNAH11 | 0.685293 | 3 | 0 | 3 |
| TCL1B | CACNB1 | 0.685222 | 6 | 0 | 5 |
For details and further investigation, click here
