ID3

 

Full name: inhibitor of DNA binding 3, HLH protein Alias Symbol: HEIR-1|bHLHb25
Type: protein-coding gene Cytoband: 1p36.12
Entrez ID: 3399 HGNC ID: HGNC:5362 Ensembl Gene: ENSG00000117318 OMIM ID: 600277
Drug and gene relationship at DGIdb

 

ID3 involved pathways:

KEGG pathway Description View
hsa04550Signaling pathways regulating pluripotency of stem cells

 

Expression of ID3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ID3 3399 207826_s_at 0.2479 0.8109
GSE20347 ID3 3399 207826_s_at 0.9738 0.0041
GSE23400 ID3 3399 207826_s_at 0.5455 0.0000
GSE26886 ID3 3399 207826_s_at 1.8848 0.0000
GSE29001 ID3 3399 207826_s_at 0.6293 0.1121
GSE38129 ID3 3399 207826_s_at 0.6407 0.0477
GSE45670 ID3 3399 207826_s_at 0.1555 0.6397
GSE53622 ID3 3399 77162 0.5824 0.0000
GSE53624 ID3 3399 77162 0.8850 0.0000
GSE63941 ID3 3399 207826_s_at -1.4017 0.1830
GSE77861 ID3 3399 207826_s_at 1.0634 0.0335
GSE97050 ID3 3399 A_23_P137381 0.4082 0.4980
SRP007169 ID3 3399 RNAseq 1.5650 0.0001
SRP008496 ID3 3399 RNAseq 2.2007 0.0000
SRP064894 ID3 3399 RNAseq 0.7768 0.0121
SRP133303 ID3 3399 RNAseq 0.7241 0.0426
SRP159526 ID3 3399 RNAseq 1.2707 0.0007
SRP193095 ID3 3399 RNAseq 0.5585 0.0700
SRP219564 ID3 3399 RNAseq 0.5202 0.5173
TCGA ID3 3399 RNAseq -0.0695 0.3830

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by ID3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ID3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ID3 3399 0 5 25
GSE20123 ID3 3399 0 4 26
GSE43470 ID3 3399 2 6 35
GSE46452 ID3 3399 5 1 53
GSE47630 ID3 3399 8 3 29
GSE54993 ID3 3399 2 1 67
GSE54994 ID3 3399 11 4 38
GSE60625 ID3 3399 0 0 11
GSE74703 ID3 3399 1 4 31
GSE74704 ID3 3399 0 0 20
TCGA ID3 3399 9 23 64

Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.  

 

Somatic mutations of ID3:

 

Generating mutation plots.

 

Highly correlated genes for ID3:

 

Showing top 20/927 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ID3FIBCD10.72481303
ID3RAB340.718867303
ID3CNTD10.717683303
ID3SCYL10.715374303
ID3AEBP10.703241908
ID3PDGFB0.700717404
ID3FADS10.699408303
ID3SLC39A130.696496505
ID3ICAM50.695657303
ID3LGALS10.69147311010
ID3ALKBH60.690619303
ID3TAF1L0.689506303
ID3ABCC10.687129404
ID3MAP3K110.677193404
ID3SLCO3A10.675138303
ID3COL4A20.67098811010
ID3COL4A50.668953807
ID3HAGLROS0.668409303
ID3TMTC10.667884403
ID3GAS2L10.667156403

For details and further investigation, click here