| Full name: pyruvate dehydrogenase kinase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 5163 | HGNC ID: HGNC:8809 | Ensembl Gene: ENSG00000152256 | OMIM ID: 602524 |
| Drug and gene relationship at DGIdb | |||
PDK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04360 | Axon guidance |
Expression of PDK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDK1 | 5163 | 226452_at | 0.5168 | 0.3731 | |
| GSE20347 | PDK1 | 5163 | 206686_at | 0.4471 | 0.0122 | |
| GSE23400 | PDK1 | 5163 | 206686_at | 0.1811 | 0.0399 | |
| GSE26886 | PDK1 | 5163 | 226452_at | 0.0786 | 0.8354 | |
| GSE29001 | PDK1 | 5163 | 206686_at | 0.2102 | 0.3924 | |
| GSE38129 | PDK1 | 5163 | 206686_at | 0.6412 | 0.0001 | |
| GSE45670 | PDK1 | 5163 | 226452_at | 0.3869 | 0.1002 | |
| GSE53622 | PDK1 | 5163 | 40963 | 0.4132 | 0.0000 | |
| GSE53624 | PDK1 | 5163 | 40963 | 0.3840 | 0.0000 | |
| GSE63941 | PDK1 | 5163 | 226452_at | -0.4026 | 0.6439 | |
| GSE77861 | PDK1 | 5163 | 226452_at | 0.6764 | 0.2172 | |
| GSE97050 | PDK1 | 5163 | A_24_P37441 | 0.1544 | 0.4834 | |
| SRP007169 | PDK1 | 5163 | RNAseq | 0.8120 | 0.1536 | |
| SRP008496 | PDK1 | 5163 | RNAseq | 0.6876 | 0.0867 | |
| SRP064894 | PDK1 | 5163 | RNAseq | 0.4581 | 0.0483 | |
| SRP133303 | PDK1 | 5163 | RNAseq | 0.6518 | 0.0143 | |
| SRP159526 | PDK1 | 5163 | RNAseq | 0.5655 | 0.0573 | |
| SRP193095 | PDK1 | 5163 | RNAseq | 0.2156 | 0.2320 | |
| SRP219564 | PDK1 | 5163 | RNAseq | 0.2405 | 0.6240 | |
| TCGA | PDK1 | 5163 | RNAseq | 0.0012 | 0.9871 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDK1 | 5163 | 9 | 0 | 21 | |
| GSE20123 | PDK1 | 5163 | 9 | 0 | 21 | |
| GSE43470 | PDK1 | 5163 | 6 | 1 | 36 | |
| GSE46452 | PDK1 | 5163 | 1 | 4 | 54 | |
| GSE47630 | PDK1 | 5163 | 5 | 3 | 32 | |
| GSE54993 | PDK1 | 5163 | 0 | 5 | 65 | |
| GSE54994 | PDK1 | 5163 | 12 | 3 | 38 | |
| GSE60625 | PDK1 | 5163 | 0 | 3 | 8 | |
| GSE74703 | PDK1 | 5163 | 5 | 1 | 30 | |
| GSE74704 | PDK1 | 5163 | 5 | 0 | 15 | |
| TCGA | PDK1 | 5163 | 28 | 6 | 62 |
Total number of gains: 80; Total number of losses: 26; Total Number of normals: 382.
Somatic mutations of PDK1:
Generating mutation plots.
Highly correlated genes for PDK1:
Showing top 20/369 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDK1 | ABCG1 | 0.774035 | 3 | 0 | 3 |
| PDK1 | EPSTI1 | 0.720302 | 3 | 0 | 3 |
| PDK1 | DNAJC7 | 0.718654 | 3 | 0 | 3 |
| PDK1 | ERGIC2 | 0.717038 | 3 | 0 | 3 |
| PDK1 | PLXND1 | 0.711682 | 3 | 0 | 3 |
| PDK1 | DDX60L | 0.711122 | 3 | 0 | 3 |
| PDK1 | NUS1 | 0.710344 | 3 | 0 | 3 |
| PDK1 | PLAGL2 | 0.706215 | 3 | 0 | 3 |
| PDK1 | PROCR | 0.695132 | 3 | 0 | 3 |
| PDK1 | NUDT21 | 0.690421 | 3 | 0 | 3 |
| PDK1 | TEP1 | 0.689458 | 4 | 0 | 4 |
| PDK1 | MRPL42 | 0.687219 | 4 | 0 | 3 |
| PDK1 | ZFYVE26 | 0.681763 | 3 | 0 | 3 |
| PDK1 | PDGFC | 0.678679 | 3 | 0 | 3 |
| PDK1 | TTC39C | 0.673492 | 3 | 0 | 3 |
| PDK1 | CD14 | 0.670567 | 3 | 0 | 3 |
| PDK1 | RLIM | 0.670193 | 4 | 0 | 3 |
| PDK1 | LIN9 | 0.666455 | 3 | 0 | 3 |
| PDK1 | MRPL9 | 0.664273 | 4 | 0 | 4 |
| PDK1 | CDCA7 | 0.66409 | 4 | 0 | 3 |
For details and further investigation, click here
