GAS1

 

Full name: growth arrest specific 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 9q21.33
Entrez ID: 2619 HGNC ID: HGNC:4165 Ensembl Gene: ENSG00000180447 OMIM ID: 139185
Drug and gene relationship at DGIdb

 

GAS1 involved pathways:

KEGG pathway Description View
hsa04340Hedgehog signaling pathway

 

Expression of GAS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GAS1 2619 204457_s_at -0.0339 0.9846
GSE20347 GAS1 2619 204457_s_at 0.8835 0.0155
GSE23400 GAS1 2619 204457_s_at 0.3940 0.0494
GSE26886 GAS1 2619 204457_s_at 2.0487 0.0000
GSE29001 GAS1 2619 204457_s_at 1.0408 0.1014
GSE38129 GAS1 2619 204457_s_at 0.0747 0.8730
GSE45670 GAS1 2619 204457_s_at -1.2590 0.0412
GSE53622 GAS1 2619 144144 0.7676 0.0001
GSE53624 GAS1 2619 144144 0.8852 0.0000
GSE63941 GAS1 2619 204457_s_at -3.8385 0.0159
GSE97050 GAS1 2619 A_23_P83134 -0.1968 0.7316
SRP007169 GAS1 2619 RNAseq 1.5762 0.0460
SRP008496 GAS1 2619 RNAseq 2.4812 0.0005
SRP064894 GAS1 2619 RNAseq 1.7060 0.0005
SRP133303 GAS1 2619 RNAseq 1.7373 0.0028
SRP159526 GAS1 2619 RNAseq 1.8429 0.0010
SRP193095 GAS1 2619 RNAseq 2.1994 0.0000
SRP219564 GAS1 2619 RNAseq 2.1143 0.0102
TCGA GAS1 2619 RNAseq 0.0952 0.5613

Upregulated datasets: 8; Downregulated datasets: 2.  

 

Survival by GAS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GAS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GAS1 2619 5 10 15
GSE20123 GAS1 2619 5 10 15
GSE43470 GAS1 2619 6 3 34
GSE46452 GAS1 2619 6 14 39
GSE47630 GAS1 2619 1 18 21
GSE54993 GAS1 2619 4 2 64
GSE54994 GAS1 2619 6 11 36
GSE60625 GAS1 2619 0 0 11
GSE74703 GAS1 2619 5 3 28
GSE74704 GAS1 2619 3 7 10
TCGA GAS1 2619 20 27 49

Total number of gains: 61; Total number of losses: 105; Total Number of normals: 322.  

 

Somatic mutations of GAS1:

 

Generating mutation plots.

 

Highly correlated genes for GAS1:

 

Showing top 20/748 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GAS1COL6A10.73879412012
GAS1FBN10.73787410010
GAS1HTRA10.73341212012
GAS1NID20.72068808
GAS1LGALS10.71696111010
GAS1COL6A20.70469912010
GAS1LAMA40.70466412011
GAS1PMP220.70086612012
GAS1OLFML30.69790912012
GAS1FSTL10.6975512011
GAS1RARRES20.69750811011
GAS1AEBP10.69533212010
GAS1PDGFC0.69275211011
GAS1ISLR0.69178412010
GAS1COL12A10.689397808
GAS1MMP20.68779611010
GAS1VIM0.68315912011
GAS1CTSK0.68130212011
GAS1GLT8D20.68017112010
GAS1RASSF80.67932707

For details and further investigation, click here