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File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Multi-Omics Database of ESCC

 

PEA15

 

Full name: proliferation and apoptosis adaptor protein 15 Alias Symbol: HMAT1|MAT1|PED|PEA-15|MAT1H|HUMMAT1H|PED-PEA15|PED/PEA15
Type: protein-coding gene Cytoband: 1q23.2
Entrez ID: 8682 HGNC ID: HGNC:8822 Ensembl Gene: ENSG00000162734 OMIM ID: 603434
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PEA15:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PEA15 8682 200788_s_at -0.2347 0.3569
GSE20347 PEA15 8682 200788_s_at -0.5888 0.0000
GSE23400 PEA15 8682 200788_s_at -0.2121 0.0007
GSE26886 PEA15 8682 200788_s_at -1.1351 0.0000
GSE29001 PEA15 8682 200788_s_at -0.5331 0.0165
GSE38129 PEA15 8682 200788_s_at -0.6150 0.0000
GSE45670 PEA15 8682 200788_s_at -0.4788 0.0039
GSE53622 PEA15 8682 134777 -0.5854 0.0000
GSE53624 PEA15 8682 134777 -0.4612 0.0000
GSE63941 PEA15 8682 200788_s_at -2.1234 0.0056
GSE77861 PEA15 8682 200788_s_at -0.5616 0.0028
GSE97050 PEA15 8682 A_24_P410952 -0.2480 0.2927
SRP007169 PEA15 8682 RNAseq -2.0931 0.0000
SRP008496 PEA15 8682 RNAseq -1.6558 0.0000
SRP064894 PEA15 8682 RNAseq -0.3805 0.0290
SRP133303 PEA15 8682 RNAseq -0.1250 0.5140
SRP159526 PEA15 8682 RNAseq -0.6527 0.0010
SRP193095 PEA15 8682 RNAseq -0.6211 0.0009
SRP219564 PEA15 8682 RNAseq -0.5963 0.0875
TCGA PEA15 8682 RNAseq 0.0360 0.4643

Upregulated datasets: 0; Downregulated datasets: 4.  

 

Survival by PEA15 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PEA15:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PEA15 8682 10 0 20
GSE20123 PEA15 8682 10 0 20
GSE43470 PEA15 8682 7 2 34
GSE46452 PEA15 8682 2 1 56
GSE47630 PEA15 8682 15 0 25
GSE54993 PEA15 8682 0 5 65
GSE54994 PEA15 8682 16 0 37
GSE60625 PEA15 8682 0 0 11
GSE74703 PEA15 8682 7 2 27
GSE74704 PEA15 8682 4 0 16
TCGA PEA15 8682 44 3 49

Total number of gains: 115; Total number of losses: 13; Total Number of normals: 360.  

 

Somatic mutations of PEA15:

 

Generating mutation plots.

 

Highly correlated genes for PEA15:

 

Showing top 20/983 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PEA15SLC44A30.755554303
PEA15CCNYL10.732531303
PEA15SNORA680.724555303
PEA15SPNS20.716501303
PEA15CLIC30.716415505
PEA15B3GNT80.716132303
PEA15SFTA20.708223303
PEA15HOTAIRM10.7013504
PEA15STBD10.696743303
PEA15RANBP90.695603706
PEA15ZFAND2B0.692539606
PEA15KLHL200.690969303
PEA15PITHD10.680845404
PEA15HSPB80.6801912012
PEA15GGA30.677458303
PEA15VAT10.6773691009
PEA15ARHGAP100.67537612011
PEA15UBE2E10.675161707
PEA15KRT780.674209504
PEA15VASN0.673373606

For details and further investigation, click here