| Full name: polyhomeotic homolog 1 | Alias Symbol: HPH1|RAE28 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 1911 | HGNC ID: HGNC:3182 | Ensembl Gene: ENSG00000111752 | OMIM ID: 602978 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PHC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHC1 | 1911 | 218338_at | -0.7211 | 0.1636 | |
| GSE20347 | PHC1 | 1911 | 218338_at | -0.7096 | 0.0000 | |
| GSE23400 | PHC1 | 1911 | 218338_at | -0.4415 | 0.0000 | |
| GSE26886 | PHC1 | 1911 | 218338_at | -1.3178 | 0.0041 | |
| GSE29001 | PHC1 | 1911 | 218338_at | -0.7552 | 0.0211 | |
| GSE38129 | PHC1 | 1911 | 218338_at | -0.8089 | 0.0000 | |
| GSE45670 | PHC1 | 1911 | 218338_at | -1.0085 | 0.0001 | |
| GSE53622 | PHC1 | 1911 | 89413 | -0.4059 | 0.0000 | |
| GSE53624 | PHC1 | 1911 | 89413 | -0.2398 | 0.0022 | |
| GSE63941 | PHC1 | 1911 | 218338_at | 0.4994 | 0.2526 | |
| GSE77861 | PHC1 | 1911 | 218338_at | -0.6667 | 0.0211 | |
| GSE97050 | PHC1 | 1911 | A_33_P3242014 | 0.3645 | 0.3189 | |
| SRP007169 | PHC1 | 1911 | RNAseq | -1.2401 | 0.0083 | |
| SRP008496 | PHC1 | 1911 | RNAseq | -0.3721 | 0.3272 | |
| SRP064894 | PHC1 | 1911 | RNAseq | -0.9649 | 0.0000 | |
| SRP133303 | PHC1 | 1911 | RNAseq | -1.1208 | 0.0000 | |
| SRP159526 | PHC1 | 1911 | RNAseq | -0.3988 | 0.3881 | |
| SRP193095 | PHC1 | 1911 | RNAseq | -0.8588 | 0.0000 | |
| SRP219564 | PHC1 | 1911 | RNAseq | -0.7264 | 0.0951 | |
| TCGA | PHC1 | 1911 | RNAseq | -0.2152 | 0.0124 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PHC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHC1 | 1911 | 6 | 3 | 21 | |
| GSE20123 | PHC1 | 1911 | 6 | 3 | 21 | |
| GSE43470 | PHC1 | 1911 | 8 | 3 | 32 | |
| GSE46452 | PHC1 | 1911 | 10 | 1 | 48 | |
| GSE47630 | PHC1 | 1911 | 12 | 2 | 26 | |
| GSE54993 | PHC1 | 1911 | 1 | 10 | 59 | |
| GSE54994 | PHC1 | 1911 | 9 | 2 | 42 | |
| GSE60625 | PHC1 | 1911 | 0 | 1 | 10 | |
| GSE74703 | PHC1 | 1911 | 8 | 2 | 26 | |
| GSE74704 | PHC1 | 1911 | 4 | 2 | 14 | |
| TCGA | PHC1 | 1911 | 40 | 6 | 50 |
Total number of gains: 104; Total number of losses: 35; Total Number of normals: 349.
Somatic mutations of PHC1:
Generating mutation plots.
Highly correlated genes for PHC1:
Showing top 20/712 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHC1 | VIT | 0.762182 | 5 | 0 | 5 |
| PHC1 | SHROOM3 | 0.703709 | 5 | 0 | 5 |
| PHC1 | SYAP1 | 0.695935 | 3 | 0 | 3 |
| PHC1 | SH3BGRL2 | 0.688472 | 5 | 0 | 4 |
| PHC1 | MAATS1 | 0.67254 | 3 | 0 | 3 |
| PHC1 | RAB11B-AS1 | 0.665521 | 4 | 0 | 4 |
| PHC1 | BOC | 0.6619 | 5 | 0 | 4 |
| PHC1 | PSEN2 | 0.660487 | 4 | 0 | 3 |
| PHC1 | KCNT2 | 0.658764 | 3 | 0 | 3 |
| PHC1 | FNDC4 | 0.656534 | 9 | 0 | 9 |
| PHC1 | ECHDC2 | 0.654542 | 10 | 0 | 9 |
| PHC1 | CCNI | 0.652346 | 9 | 0 | 9 |
| PHC1 | DDAH1 | 0.651671 | 10 | 0 | 8 |
| PHC1 | VSIG2 | 0.648693 | 4 | 0 | 4 |
| PHC1 | ATXN7L3B | 0.648073 | 3 | 0 | 3 |
| PHC1 | SLC7A3 | 0.64664 | 3 | 0 | 3 |
| PHC1 | MAMDC2 | 0.646107 | 4 | 0 | 4 |
| PHC1 | FAM149B1 | 0.64307 | 10 | 0 | 8 |
| PHC1 | SNORA68 | 0.638868 | 4 | 0 | 3 |
| PHC1 | RASSF5 | 0.637984 | 4 | 0 | 4 |
For details and further investigation, click here
