| Full name: dimethylarginine dimethylaminohydrolase 1 | Alias Symbol: DDAH | ||
| Type: protein-coding gene | Cytoband: 1p22.3 | ||
| Entrez ID: 23576 | HGNC ID: HGNC:2715 | Ensembl Gene: ENSG00000153904 | OMIM ID: 604743 |
| Drug and gene relationship at DGIdb | |||
Expression of DDAH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDAH1 | 23576 | 209094_at | -2.0608 | 0.0182 | |
| GSE20347 | DDAH1 | 23576 | 209094_at | -2.2311 | 0.0000 | |
| GSE23400 | DDAH1 | 23576 | 209094_at | -0.8450 | 0.0000 | |
| GSE26886 | DDAH1 | 23576 | 209094_at | -1.9202 | 0.0001 | |
| GSE29001 | DDAH1 | 23576 | 209094_at | -2.2373 | 0.0009 | |
| GSE38129 | DDAH1 | 23576 | 209094_at | -1.6623 | 0.0000 | |
| GSE45670 | DDAH1 | 23576 | 209094_at | -2.0241 | 0.0000 | |
| GSE53622 | DDAH1 | 23576 | 53970 | -1.4693 | 0.0000 | |
| GSE53624 | DDAH1 | 23576 | 53970 | -1.8561 | 0.0000 | |
| GSE63941 | DDAH1 | 23576 | 209094_at | -2.1458 | 0.0360 | |
| GSE77861 | DDAH1 | 23576 | 209094_at | -2.0264 | 0.0052 | |
| GSE97050 | DDAH1 | 23576 | A_23_P201386 | -0.5029 | 0.1832 | |
| SRP007169 | DDAH1 | 23576 | RNAseq | -1.6398 | 0.0054 | |
| SRP008496 | DDAH1 | 23576 | RNAseq | -1.4279 | 0.0001 | |
| SRP064894 | DDAH1 | 23576 | RNAseq | -1.0399 | 0.0000 | |
| SRP133303 | DDAH1 | 23576 | RNAseq | -1.0978 | 0.0002 | |
| SRP159526 | DDAH1 | 23576 | RNAseq | -1.4511 | 0.0000 | |
| SRP193095 | DDAH1 | 23576 | RNAseq | -1.3720 | 0.0001 | |
| SRP219564 | DDAH1 | 23576 | RNAseq | -1.0722 | 0.0270 | |
| TCGA | DDAH1 | 23576 | RNAseq | -0.8011 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by DDAH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDAH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDAH1 | 23576 | 0 | 8 | 22 | |
| GSE20123 | DDAH1 | 23576 | 0 | 8 | 22 | |
| GSE43470 | DDAH1 | 23576 | 2 | 4 | 37 | |
| GSE46452 | DDAH1 | 23576 | 1 | 1 | 57 | |
| GSE47630 | DDAH1 | 23576 | 8 | 5 | 27 | |
| GSE54993 | DDAH1 | 23576 | 0 | 1 | 69 | |
| GSE54994 | DDAH1 | 23576 | 6 | 3 | 44 | |
| GSE60625 | DDAH1 | 23576 | 0 | 0 | 11 | |
| GSE74703 | DDAH1 | 23576 | 1 | 3 | 32 | |
| GSE74704 | DDAH1 | 23576 | 0 | 5 | 15 | |
| TCGA | DDAH1 | 23576 | 7 | 23 | 66 |
Total number of gains: 25; Total number of losses: 61; Total Number of normals: 402.
Somatic mutations of DDAH1:
Generating mutation plots.
Highly correlated genes for DDAH1:
Showing top 20/1572 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDAH1 | PAQR8 | 0.82146 | 7 | 0 | 7 |
| DDAH1 | CGNL1 | 0.798507 | 7 | 0 | 7 |
| DDAH1 | SH3BGRL2 | 0.785684 | 7 | 0 | 7 |
| DDAH1 | SFTA2 | 0.785288 | 4 | 0 | 4 |
| DDAH1 | SAMD5 | 0.767623 | 7 | 0 | 7 |
| DDAH1 | LIFR | 0.759322 | 5 | 0 | 5 |
| DDAH1 | PAIP2B | 0.755995 | 11 | 0 | 11 |
| DDAH1 | UBL3 | 0.747035 | 10 | 0 | 10 |
| DDAH1 | LRP11 | 0.746098 | 3 | 0 | 3 |
| DDAH1 | MTMR10 | 0.745391 | 7 | 0 | 7 |
| DDAH1 | PHYHD1 | 0.744374 | 7 | 0 | 7 |
| DDAH1 | SNORA68 | 0.741 | 4 | 0 | 4 |
| DDAH1 | CA13 | 0.740954 | 3 | 0 | 3 |
| DDAH1 | NUCB2 | 0.740057 | 11 | 0 | 11 |
| DDAH1 | FAM3D | 0.738846 | 6 | 0 | 6 |
| DDAH1 | ZNF662 | 0.73582 | 8 | 0 | 8 |
| DDAH1 | TSC22D2 | 0.735619 | 3 | 0 | 3 |
| DDAH1 | LMBRD1 | 0.735268 | 11 | 0 | 11 |
| DDAH1 | SLC4A4 | 0.734442 | 7 | 0 | 6 |
| DDAH1 | KCTD6 | 0.73228 | 8 | 0 | 7 |
For details and further investigation, click here
