| Full name: polyhomeotic homolog 3 | Alias Symbol: EDR3|FLJ12967|FLJ12729|HPH3 | ||
| Type: protein-coding gene | Cytoband: 3q26.2 | ||
| Entrez ID: 80012 | HGNC ID: HGNC:15682 | Ensembl Gene: ENSG00000173889 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PHC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHC3 | 80012 | 226508_at | 0.3964 | 0.4473 | |
| GSE20347 | PHC3 | 80012 | 215521_at | 0.5584 | 0.0003 | |
| GSE23400 | PHC3 | 80012 | 215521_at | 0.3395 | 0.0000 | |
| GSE26886 | PHC3 | 80012 | 226508_at | 0.7903 | 0.0002 | |
| GSE29001 | PHC3 | 80012 | 215521_at | 0.3159 | 0.0334 | |
| GSE38129 | PHC3 | 80012 | 215521_at | 0.3931 | 0.0143 | |
| GSE45670 | PHC3 | 80012 | 226508_at | 0.0259 | 0.9121 | |
| GSE53622 | PHC3 | 80012 | 21801 | 0.0445 | 0.5799 | |
| GSE53624 | PHC3 | 80012 | 21801 | 0.2463 | 0.0000 | |
| GSE63941 | PHC3 | 80012 | 226508_at | 0.0572 | 0.9172 | |
| GSE77861 | PHC3 | 80012 | 226508_at | 0.7684 | 0.0129 | |
| GSE97050 | PHC3 | 80012 | A_33_P3400324 | -0.2322 | 0.4580 | |
| SRP007169 | PHC3 | 80012 | RNAseq | 0.9191 | 0.0216 | |
| SRP008496 | PHC3 | 80012 | RNAseq | 1.1136 | 0.0000 | |
| SRP064894 | PHC3 | 80012 | RNAseq | 0.4722 | 0.0627 | |
| SRP133303 | PHC3 | 80012 | RNAseq | 0.5822 | 0.0000 | |
| SRP159526 | PHC3 | 80012 | RNAseq | 0.6126 | 0.0330 | |
| SRP193095 | PHC3 | 80012 | RNAseq | 0.6537 | 0.0000 | |
| SRP219564 | PHC3 | 80012 | RNAseq | 0.2393 | 0.5161 | |
| TCGA | PHC3 | 80012 | RNAseq | -0.0335 | 0.5296 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PHC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHC3 | 80012 | 22 | 0 | 8 | |
| GSE20123 | PHC3 | 80012 | 22 | 0 | 8 | |
| GSE43470 | PHC3 | 80012 | 24 | 0 | 19 | |
| GSE46452 | PHC3 | 80012 | 19 | 1 | 39 | |
| GSE47630 | PHC3 | 80012 | 27 | 2 | 11 | |
| GSE54993 | PHC3 | 80012 | 1 | 14 | 55 | |
| GSE54994 | PHC3 | 80012 | 41 | 0 | 12 | |
| GSE60625 | PHC3 | 80012 | 0 | 6 | 5 | |
| GSE74703 | PHC3 | 80012 | 20 | 0 | 16 | |
| GSE74704 | PHC3 | 80012 | 14 | 0 | 6 | |
| TCGA | PHC3 | 80012 | 80 | 0 | 16 |
Total number of gains: 270; Total number of losses: 23; Total Number of normals: 195.
Somatic mutations of PHC3:
Generating mutation plots.
Highly correlated genes for PHC3:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHC3 | TECPR2 | 0.725284 | 4 | 0 | 4 |
| PHC3 | SLC41A1 | 0.696336 | 4 | 0 | 4 |
| PHC3 | ABHD8 | 0.691007 | 3 | 0 | 3 |
| PHC3 | FBN1 | 0.69084 | 3 | 0 | 3 |
| PHC3 | LINC00674 | 0.688998 | 4 | 0 | 3 |
| PHC3 | DIP2A | 0.683266 | 5 | 0 | 4 |
| PHC3 | WIPF3 | 0.680781 | 3 | 0 | 3 |
| PHC3 | ZCRB1 | 0.668473 | 4 | 0 | 3 |
| PHC3 | PLEKHA3 | 0.665191 | 6 | 0 | 4 |
| PHC3 | ITPK1 | 0.663868 | 4 | 0 | 4 |
| PHC3 | PJA1 | 0.659768 | 4 | 0 | 3 |
| PHC3 | TAOK1 | 0.656941 | 6 | 0 | 5 |
| PHC3 | PLEKHH2 | 0.656739 | 4 | 0 | 3 |
| PHC3 | PRRC2B | 0.656049 | 5 | 0 | 4 |
| PHC3 | FZD3 | 0.649168 | 4 | 0 | 4 |
| PHC3 | CERS5 | 0.649133 | 4 | 0 | 3 |
| PHC3 | CTDSPL2 | 0.643573 | 3 | 0 | 3 |
| PHC3 | CALML4 | 0.641526 | 6 | 0 | 5 |
| PHC3 | PSMD2 | 0.640364 | 4 | 0 | 3 |
| PHC3 | CNTNAP2 | 0.640119 | 3 | 0 | 3 |
For details and further investigation, click here
