CTDSPL2

 

Full name: CTD small phosphatase like 2 Alias Symbol: HSPC129|FLJ10523
Type: protein-coding gene Cytoband: 15q15.3-q21.1
Entrez ID: 51496 HGNC ID: HGNC:26936 Ensembl Gene: ENSG00000137770 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CTDSPL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CTDSPL2 51496 223271_s_at 0.4974 0.3636
GSE26886 CTDSPL2 51496 223270_at 0.6221 0.0045
GSE45670 CTDSPL2 51496 223271_s_at 0.3149 0.1001
GSE53622 CTDSPL2 51496 110646 0.4603 0.0000
GSE53624 CTDSPL2 51496 110646 0.5461 0.0001
GSE63941 CTDSPL2 51496 223271_s_at 1.3154 0.0023
GSE77861 CTDSPL2 51496 223271_s_at 0.4788 0.1295
GSE97050 CTDSPL2 51496 A_32_P76060 0.2119 0.3514
SRP007169 CTDSPL2 51496 RNAseq 0.6611 0.0586
SRP008496 CTDSPL2 51496 RNAseq 0.8800 0.0001
SRP064894 CTDSPL2 51496 RNAseq 0.2177 0.3608
SRP133303 CTDSPL2 51496 RNAseq 0.5640 0.0020
SRP159526 CTDSPL2 51496 RNAseq 0.4329 0.0464
SRP193095 CTDSPL2 51496 RNAseq 0.3683 0.0000
SRP219564 CTDSPL2 51496 RNAseq 0.0644 0.8343
TCGA CTDSPL2 51496 RNAseq 0.1729 0.0010

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CTDSPL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTDSPL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTDSPL2 51496 3 4 23
GSE20123 CTDSPL2 51496 3 5 22
GSE43470 CTDSPL2 51496 4 4 35
GSE46452 CTDSPL2 51496 3 7 49
GSE47630 CTDSPL2 51496 8 10 22
GSE54993 CTDSPL2 51496 4 6 60
GSE54994 CTDSPL2 51496 5 7 41
GSE60625 CTDSPL2 51496 4 0 7
GSE74703 CTDSPL2 51496 4 3 29
GSE74704 CTDSPL2 51496 2 2 16
TCGA CTDSPL2 51496 12 17 67

Total number of gains: 52; Total number of losses: 65; Total Number of normals: 371.  

 

Somatic mutations of CTDSPL2:

 

Generating mutation plots.

 

Highly correlated genes for CTDSPL2:

 

Showing top 20/888 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTDSPL2ZDHHC70.792433303
CTDSPL2EIF4A30.758068303
CTDSPL2MRPL380.752758303
CTDSPL2NUDT40.75057303
CTDSPL2CWF19L10.746956505
CTDSPL2ORAI10.746789303
CTDSPL2NOL90.743547303
CTDSPL2FAF20.742199303
CTDSPL2PPP6R30.740826404
CTDSPL2SNX130.735405303
CTDSPL2GABPB10.72878404
CTDSPL2PTGES30.727041404
CTDSPL2PPP5C0.725005303
CTDSPL2FASTKD20.723775303
CTDSPL2FCF10.718534303
CTDSPL2MRPL130.715838303
CTDSPL2ANKRD500.712946303
CTDSPL2MRPL110.711761404
CTDSPL2ZNF1210.709062303
CTDSPL2TMEM1650.707864303

For details and further investigation, click here