| Full name: pleckstrin homology like domain family A member 3 | Alias Symbol: TIH1 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 23612 | HGNC ID: HGNC:8934 | Ensembl Gene: ENSG00000174307 | OMIM ID: 607054 |
| Drug and gene relationship at DGIdb | |||
Expression of PHLDA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHLDA3 | 23612 | 218634_at | 0.2185 | 0.5548 | |
| GSE20347 | PHLDA3 | 23612 | 218634_at | -0.0671 | 0.7219 | |
| GSE23400 | PHLDA3 | 23612 | 218634_at | 0.0466 | 0.4734 | |
| GSE26886 | PHLDA3 | 23612 | 218634_at | -0.3345 | 0.2759 | |
| GSE29001 | PHLDA3 | 23612 | 218634_at | 0.0098 | 0.9772 | |
| GSE38129 | PHLDA3 | 23612 | 218634_at | -0.0332 | 0.8477 | |
| GSE53622 | PHLDA3 | 23612 | 57804 | 0.2951 | 0.0001 | |
| GSE53624 | PHLDA3 | 23612 | 57804 | -0.0941 | 0.1556 | |
| GSE63941 | PHLDA3 | 23612 | 218634_at | 0.2071 | 0.5650 | |
| GSE77861 | PHLDA3 | 23612 | 218634_at | 0.0928 | 0.7660 | |
| GSE97050 | PHLDA3 | 23612 | A_33_P3252834 | 0.4571 | 0.1239 | |
| SRP007169 | PHLDA3 | 23612 | RNAseq | -0.8196 | 0.0741 | |
| SRP008496 | PHLDA3 | 23612 | RNAseq | -0.6174 | 0.0731 | |
| SRP064894 | PHLDA3 | 23612 | RNAseq | 0.2113 | 0.5138 | |
| SRP133303 | PHLDA3 | 23612 | RNAseq | 0.1363 | 0.5400 | |
| SRP159526 | PHLDA3 | 23612 | RNAseq | -0.2751 | 0.3098 | |
| SRP193095 | PHLDA3 | 23612 | RNAseq | -0.4611 | 0.0506 | |
| SRP219564 | PHLDA3 | 23612 | RNAseq | -0.5339 | 0.1371 | |
| TCGA | PHLDA3 | 23612 | RNAseq | 0.3589 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PHLDA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHLDA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHLDA3 | 23612 | 11 | 0 | 19 | |
| GSE20123 | PHLDA3 | 23612 | 11 | 0 | 19 | |
| GSE43470 | PHLDA3 | 23612 | 6 | 0 | 37 | |
| GSE46452 | PHLDA3 | 23612 | 3 | 1 | 55 | |
| GSE47630 | PHLDA3 | 23612 | 14 | 0 | 26 | |
| GSE54993 | PHLDA3 | 23612 | 0 | 6 | 64 | |
| GSE54994 | PHLDA3 | 23612 | 15 | 0 | 38 | |
| GSE60625 | PHLDA3 | 23612 | 0 | 0 | 11 | |
| GSE74703 | PHLDA3 | 23612 | 6 | 0 | 30 | |
| GSE74704 | PHLDA3 | 23612 | 5 | 0 | 15 | |
| TCGA | PHLDA3 | 23612 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of PHLDA3:
Generating mutation plots.
Highly correlated genes for PHLDA3:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHLDA3 | PFN1 | 0.774425 | 3 | 0 | 3 |
| PHLDA3 | CORO7 | 0.773463 | 3 | 0 | 3 |
| PHLDA3 | ZNF598 | 0.737667 | 3 | 0 | 3 |
| PHLDA3 | BCL7B | 0.709948 | 4 | 0 | 4 |
| PHLDA3 | CDK2AP1 | 0.691494 | 3 | 0 | 3 |
| PHLDA3 | NOTCH3 | 0.688495 | 3 | 0 | 3 |
| PHLDA3 | HOXA7 | 0.679794 | 3 | 0 | 3 |
| PHLDA3 | C9orf116 | 0.67758 | 3 | 0 | 3 |
| PHLDA3 | CREB3L1 | 0.671696 | 3 | 0 | 3 |
| PHLDA3 | UBA1 | 0.671484 | 3 | 0 | 3 |
| PHLDA3 | RNF25 | 0.669749 | 3 | 0 | 3 |
| PHLDA3 | ARMC6 | 0.665607 | 3 | 0 | 3 |
| PHLDA3 | RRP9 | 0.662929 | 3 | 0 | 3 |
| PHLDA3 | ZDHHC24 | 0.659094 | 3 | 0 | 3 |
| PHLDA3 | TNK1 | 0.656709 | 3 | 0 | 3 |
| PHLDA3 | CSNK1D | 0.655755 | 3 | 0 | 3 |
| PHLDA3 | FAM86C1 | 0.649696 | 3 | 0 | 3 |
| PHLDA3 | ARF3 | 0.647374 | 4 | 0 | 4 |
| PHLDA3 | ICMT | 0.644595 | 3 | 0 | 3 |
| PHLDA3 | BMP8A | 0.637503 | 3 | 0 | 3 |
For details and further investigation, click here
