| Full name: cyclin dependent kinase 2 associated protein 1 | Alias Symbol: DORC1|doc-1|DOC1|ST19|p12DOC-1 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 8099 | HGNC ID: HGNC:14002 | Ensembl Gene: ENSG00000111328 | OMIM ID: 602198 |
| Drug and gene relationship at DGIdb | |||
Expression of CDK2AP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK2AP1 | 8099 | 201938_at | 0.3426 | 0.2575 | |
| GSE20347 | CDK2AP1 | 8099 | 201938_at | 0.3154 | 0.0037 | |
| GSE23400 | CDK2AP1 | 8099 | 201938_at | 0.4708 | 0.0000 | |
| GSE26886 | CDK2AP1 | 8099 | 201938_at | 0.4085 | 0.0446 | |
| GSE29001 | CDK2AP1 | 8099 | 201938_at | 0.3191 | 0.0131 | |
| GSE38129 | CDK2AP1 | 8099 | 201938_at | 0.4286 | 0.0000 | |
| GSE45670 | CDK2AP1 | 8099 | 201938_at | 0.2716 | 0.0068 | |
| GSE63941 | CDK2AP1 | 8099 | 201938_at | -1.2912 | 0.0134 | |
| GSE77861 | CDK2AP1 | 8099 | 201938_at | 0.1178 | 0.5418 | |
| GSE97050 | CDK2AP1 | 8099 | A_23_P139486 | 0.7552 | 0.0631 | |
| SRP007169 | CDK2AP1 | 8099 | RNAseq | -0.0946 | 0.7530 | |
| SRP008496 | CDK2AP1 | 8099 | RNAseq | 0.0558 | 0.8014 | |
| SRP064894 | CDK2AP1 | 8099 | RNAseq | 0.3673 | 0.0220 | |
| SRP133303 | CDK2AP1 | 8099 | RNAseq | 0.4507 | 0.0015 | |
| SRP159526 | CDK2AP1 | 8099 | RNAseq | 1.0257 | 0.0062 | |
| SRP193095 | CDK2AP1 | 8099 | RNAseq | 0.2787 | 0.0996 | |
| SRP219564 | CDK2AP1 | 8099 | RNAseq | 0.1183 | 0.6932 | |
| TCGA | CDK2AP1 | 8099 | RNAseq | 0.2580 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CDK2AP1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CDK2AP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK2AP1 | 8099 | 5 | 5 | 20 | |
| GSE20123 | CDK2AP1 | 8099 | 5 | 5 | 20 | |
| GSE43470 | CDK2AP1 | 8099 | 2 | 1 | 40 | |
| GSE46452 | CDK2AP1 | 8099 | 9 | 1 | 49 | |
| GSE47630 | CDK2AP1 | 8099 | 9 | 3 | 28 | |
| GSE54993 | CDK2AP1 | 8099 | 0 | 5 | 65 | |
| GSE54994 | CDK2AP1 | 8099 | 4 | 8 | 41 | |
| GSE60625 | CDK2AP1 | 8099 | 0 | 0 | 11 | |
| GSE74703 | CDK2AP1 | 8099 | 2 | 0 | 34 | |
| GSE74704 | CDK2AP1 | 8099 | 3 | 3 | 14 | |
| TCGA | CDK2AP1 | 8099 | 21 | 11 | 64 |
Total number of gains: 60; Total number of losses: 42; Total Number of normals: 386.
Somatic mutations of CDK2AP1:
Generating mutation plots.
Highly correlated genes for CDK2AP1:
Showing top 20/908 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK2AP1 | TM2D2 | 0.857691 | 3 | 0 | 3 |
| CDK2AP1 | SIX4 | 0.728531 | 3 | 0 | 3 |
| CDK2AP1 | MASTL | 0.728271 | 3 | 0 | 3 |
| CDK2AP1 | RRP1B | 0.709424 | 4 | 0 | 4 |
| CDK2AP1 | LCLAT1 | 0.707092 | 3 | 0 | 3 |
| CDK2AP1 | MPV17L2 | 0.706818 | 3 | 0 | 3 |
| CDK2AP1 | RAN | 0.70383 | 6 | 0 | 6 |
| CDK2AP1 | CDK6 | 0.702773 | 4 | 0 | 3 |
| CDK2AP1 | PHLDA3 | 0.691494 | 3 | 0 | 3 |
| CDK2AP1 | WIPF1 | 0.689714 | 3 | 0 | 3 |
| CDK2AP1 | GLIS3 | 0.689418 | 3 | 0 | 3 |
| CDK2AP1 | NCAPG2 | 0.687465 | 7 | 0 | 6 |
| CDK2AP1 | FARS2 | 0.687311 | 3 | 0 | 3 |
| CDK2AP1 | COMMD2 | 0.683687 | 4 | 0 | 3 |
| CDK2AP1 | BPNT1 | 0.683436 | 3 | 0 | 3 |
| CDK2AP1 | CEP55 | 0.682249 | 7 | 0 | 7 |
| CDK2AP1 | CKAP4 | 0.681314 | 3 | 0 | 3 |
| CDK2AP1 | LRRC58 | 0.680209 | 4 | 0 | 4 |
| CDK2AP1 | CCDC102B | 0.678414 | 3 | 0 | 3 |
| CDK2AP1 | ISY1 | 0.674836 | 3 | 0 | 3 |
For details and further investigation, click here
