| Full name: tyrosine kinase non receptor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 8711 | HGNC ID: HGNC:11940 | Ensembl Gene: ENSG00000174292 | OMIM ID: 608076 |
| Drug and gene relationship at DGIdb | |||
Expression of TNK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNK1 | 8711 | 217149_x_at | 0.4180 | 0.2371 | |
| GSE20347 | TNK1 | 8711 | 205793_x_at | 0.1274 | 0.1911 | |
| GSE23400 | TNK1 | 8711 | 217149_x_at | 0.0403 | 0.5065 | |
| GSE26886 | TNK1 | 8711 | 217149_x_at | 0.6058 | 0.0000 | |
| GSE29001 | TNK1 | 8711 | 217149_x_at | -0.1449 | 0.5670 | |
| GSE38129 | TNK1 | 8711 | 217149_x_at | 0.2205 | 0.1090 | |
| GSE45670 | TNK1 | 8711 | 205793_x_at | 0.1653 | 0.1081 | |
| GSE53622 | TNK1 | 8711 | 65952 | 0.5321 | 0.0000 | |
| GSE53624 | TNK1 | 8711 | 65952 | 0.5272 | 0.0000 | |
| GSE63941 | TNK1 | 8711 | 217149_x_at | 0.9038 | 0.0027 | |
| GSE77861 | TNK1 | 8711 | 217149_x_at | 0.2074 | 0.2533 | |
| GSE97050 | TNK1 | 8711 | A_33_P3388618 | 0.3834 | 0.1584 | |
| SRP007169 | TNK1 | 8711 | RNAseq | 0.7298 | 0.2719 | |
| SRP008496 | TNK1 | 8711 | RNAseq | 1.2008 | 0.0038 | |
| SRP064894 | TNK1 | 8711 | RNAseq | 0.6148 | 0.0168 | |
| SRP133303 | TNK1 | 8711 | RNAseq | 0.5941 | 0.0038 | |
| SRP159526 | TNK1 | 8711 | RNAseq | 0.5775 | 0.0059 | |
| SRP193095 | TNK1 | 8711 | RNAseq | 0.5353 | 0.0007 | |
| SRP219564 | TNK1 | 8711 | RNAseq | 0.3995 | 0.4548 | |
| TCGA | TNK1 | 8711 | RNAseq | 0.0651 | 0.3992 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TNK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNK1 | 8711 | 4 | 2 | 24 | |
| GSE20123 | TNK1 | 8711 | 4 | 3 | 23 | |
| GSE43470 | TNK1 | 8711 | 1 | 4 | 38 | |
| GSE46452 | TNK1 | 8711 | 34 | 1 | 24 | |
| GSE47630 | TNK1 | 8711 | 7 | 1 | 32 | |
| GSE54993 | TNK1 | 8711 | 4 | 3 | 63 | |
| GSE54994 | TNK1 | 8711 | 5 | 8 | 40 | |
| GSE60625 | TNK1 | 8711 | 4 | 0 | 7 | |
| GSE74703 | TNK1 | 8711 | 1 | 2 | 33 | |
| GSE74704 | TNK1 | 8711 | 2 | 1 | 17 | |
| TCGA | TNK1 | 8711 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of TNK1:
Generating mutation plots.
Highly correlated genes for TNK1:
Showing top 20/1026 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNK1 | CD22 | 0.824231 | 3 | 0 | 3 |
| TNK1 | KLHDC3 | 0.812478 | 3 | 0 | 3 |
| TNK1 | LYRM4 | 0.781679 | 3 | 0 | 3 |
| TNK1 | CTNS | 0.770226 | 3 | 0 | 3 |
| TNK1 | KHDRBS1 | 0.76853 | 3 | 0 | 3 |
| TNK1 | ANKRD54 | 0.767567 | 3 | 0 | 3 |
| TNK1 | RALGAPA2 | 0.766542 | 3 | 0 | 3 |
| TNK1 | POLA1 | 0.756084 | 3 | 0 | 3 |
| TNK1 | COMMD7 | 0.74989 | 4 | 0 | 4 |
| TNK1 | C9orf16 | 0.749681 | 5 | 0 | 4 |
| TNK1 | MOSPD3 | 0.744005 | 5 | 0 | 5 |
| TNK1 | KRTCAP2 | 0.741751 | 4 | 0 | 3 |
| TNK1 | TMEM189 | 0.739145 | 3 | 0 | 3 |
| TNK1 | PRDM15 | 0.736541 | 3 | 0 | 3 |
| TNK1 | KIAA0895 | 0.731447 | 4 | 0 | 3 |
| TNK1 | RAVER1 | 0.729978 | 5 | 0 | 5 |
| TNK1 | ALDH5A1 | 0.728033 | 3 | 0 | 3 |
| TNK1 | TRAPPC1 | 0.724178 | 5 | 0 | 4 |
| TNK1 | POGZ | 0.721589 | 3 | 0 | 3 |
| TNK1 | MRPL38 | 0.7193 | 4 | 0 | 4 |
For details and further investigation, click here
